Formulation, structure, and applications of therapeutic and amino acid-based deep eutectic solvents: An overview

Rahman, Sajjadur; Roy, Ranen; Jadhav, Balawanthrao; Hossain, Nayeem; Halim, Mohammad A.; Raynie, Douglas E.

doi:10.1016/j.molliq.2020.114745

Cited by 81 publications

(35 citation statements)

References 97 publications

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“…Timeline of DES exploration of specific applications. Solvent properties of DES, [30] carboxylic acid with ChCl DES properties, [31] ionothermal materials synthesis, [32] nickel electrodeposition, [33] biocatalytic application, [34] drug solubilization, [35] synthesis of photoluminescence and photochromisn, [36] enzyme activation, [37] synthesis of polymer and related materials, [38] natural DES for extraction of phenolic metabolites, [39] electrolytic function for supercapacitors [40] and application in nanotechnology, [41] tailoring properties of DES with water [42] and solvent for separation, [43] organocatalytic-biotransformation activity of DES, [44] application in biotechnology, [45] bio-inspired electrolyte for LIBs, [46] biomass pretreatment using DES, [47] theuraputic application, [48] and separation of quazrt and magnetie. [49] provides a summary of initial DESs applied in different topics by time.…”

Section: History Of Deep Eutectic Solvents (Des)mentioning

confidence: 99%

“…[49] provides a summary of initial DESs applied in different topics by time. [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49] Generally, DESs are formed when the donor and the acceptor of compounds are bound by hydrogen bond at ambient temperature in a liquid state. A variety of common hydrogen donors and acceptors for the preparation of DESs were exhibited in Figure 2.…”

Section: History Of Deep Eutectic Solvents (Des)mentioning

confidence: 99%

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Deep Eutectic Solvents: Green Approach for Cathode Recycling of Li‐Ion Batteries

Padwal

Pham

Jadhav

et al. 2021

Adv Energy and Sustain Res

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Lithium-ion batteries (LIBs) are highvoltage, high-energy, and high-power density energy storage devices with long cycle life, therefore intensively applied in full and hybrid electric vehicles, portable electronic devices (computers, mobile phones, and tablet), and renewable (solar and wind) sector. [1,2] Typically, LIBs for such applications with estimated lifetime of around 3-10 years generate a vast amount of waste at their end-of-life. [3,4] It is estimated that over 11 million tonnes of spent LIBs will be discarded through to 2030, and only less than 5% of them are being recycled. [4] Moreover, due to rapidly increasing demand of LIBs, the price of crucial element resources (Li, Ni, and Co) is also significantly increasing. In contrast, the health and environmental concerns may arise in the event of large, accumulated quantities of cobalt and lithium metals, which typically constitutes up to 20 and 7 wt%, respectively, of LIB cathodes, as well as toxic and flammable electrolytes (e.g., lithium hexafluorophosphate, LiPF 6 ). [3][4][5] Therefore, efficient recovery of such raw materials in spent LIBs is extremely crucial.At present, LIBs are recycled commercially using well-known processes such as pyrometallurgy, hydrometallurgy, and direct recycling. [4] However, these processes do not extract the maximum value from their feedstock. For instance, pyrometallurgy, or smelting operate at very high temperature (over 1100 C), which eliminates several materials (carbon anode, plastic separator, and electrolyte solvents) through vaporization (electrolyte), combustion, and melting. The final product is a mixed alloy of cobalt, nickel, and copper. The concept of direct recycling is simple: keep the cathode crystal structure intact. The definition of direct recycling is the recovery, regeneration, and reuse of battery components directly without breaking down the chemical structure. It has also been called direct cathode recycling and cathode-to-cathode recycling. By recovering cathode material, several energy-intensive and costly processing steps can be avoided. Not only does recovery of more materials offer potential additional revenues, but also costs and other impacts from waste treatment can be avoided. Advantages include low temperatures and low energy consumption, and the avoidance of most impacts from virgin material production.

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Section: History Of Deep Eutectic Solvents (Des)mentioning

confidence: 99%

Section: History Of Deep Eutectic Solvents (Des)mentioning

confidence: 99%

Deep Eutectic Solvents: Green Approach for Cathode Recycling of Li‐Ion Batteries

Padwal

Pham

Jadhav

et al. 2021

Adv Energy and Sustain Res

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“…The applications of DESs as pharmaceutical tools have been a matter of a huge amount of research efforts over the last five years, and their improvement is currently under continuous development. The remarkable results achieved in this field have been recently extensively reviewed in the literature [111] and are summarized in Figure 3. DESs represent a safer and biocompatible alternative to organic solvents for the solubilization of poorly water-soluble APIs, in particular for topical formulations.…”

Section: Deep Eutectic Solvents In Medicinementioning

confidence: 99%

“…While the HBA portion of these DESs (ChCl) is a safe and non-expensive compound which fulfils most of the sustainability principles, the choice of the HBDs has to be carefully addressed since many HBD components might possess a significant toxicity. Several drugs have shown a dramatically increase of their solubility in DESs compared to water, raised up to 5400-fold for ibuprofen [ 112 ], 6400-fold for posaconazole in binary eutectic systems [ 113 ] and up to 53,600-fold for the antifungal drug itraconazole in a ternary ChCl:Glycolic acid:oxalic acid (1:1.6:0.4) deep eutectic mixture [ 111 ]. Furthermore, DESs could improve the chemical stability of APIs, as observed for aspirin [ 110 ] and β-lactams antibiotics [ 114 ].…”

Section: Deep Eutectic Solvents In Medicinementioning

confidence: 99%

Promising Technological and Industrial Applications of Deep Eutectic Systems

et al. 2021

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Deep Eutectic Systems (DESs) are obtained by combining Hydrogen Bond Acceptors (HBAs) and Hydrogen Bond Donors (HBDs) in specific molar ratios. Since their first appearance in the literature in 2003, they have shown a wide range of applications, ranging from the selective extraction of biomass or metals to medicine, as well as from pollution control systems to catalytic active solvents and co-solvents. The very peculiar physical properties of DESs, such as the elevated density and viscosity, reduced conductivity, improved solvent ability and a peculiar optical behavior, can be exploited for engineering modular systems which cannot be obtained with other non-eutectic mixtures. In the present review, selected DESs research fields, as their use in materials synthesis, as solvents for volatile organic compounds, as ingredients in pharmaceutical formulations and as active solvents and cosolvents in organic synthesis, are reported and discussed in terms of application and future perspectives.

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“…THEDESs have become more attractive in the pharmaceutical field due to their ability to increase APIs’ bioavailability. A popular monoterpene, menthol, is one of the most common hydrogen bond acceptors (HBAs) among the THEDESs [ 94 ] and has already been combined with a large variety of APIs (e.g., ibuprofen, lidocaine, fluconazole and captopril) to create such eutectic systems [ 93 ].…”

Section: Therapeutic Deep Eutectic Solventsmentioning

confidence: 99%

Selected Monocyclic Monoterpenes and Their Derivatives as Effective Anticancer Therapeutic Agents

Zielińska-Błajet

Pietrusiak

Feder‐Kubis

2021

IJMS

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Terpenes—a diverse group of secondary metabolites—constitute the largest class of natural products abundant in almost every plant species. The properties of concrete terpenes and essential oils have been intensively studied due to their widespread use in the pharmaceutical, food and cosmetics industries. Despite the popularity of these aromatic compounds, their derivatives, terpenoids, are still not comprehensively characterized despite exhibiting potent bioactive properties. This review aims to assess the anticancer properties of selected monoterpenes including carvone, carvacrol, perillyl alcohol, perillaldehyde, limonene, menthol and their derivatives while also evaluating potential applications as novel anticancer treatments. Special attention is paid to functional groups that improve the bioactivity of monoterpene molecules. This review also covers the therapeutic potential of deep eutectic solvents that contain monoterpene substances. Taken together, the literature supports the use of monoterpene derivatives in the development of new alternatives for disease treatment and prevention.

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Formulation, structure, and applications of therapeutic and amino acid-based deep eutectic solvents: An overview

Cited by 81 publications

References 97 publications

Deep Eutectic Solvents: Green Approach for Cathode Recycling of Li‐Ion Batteries

Deep Eutectic Solvents: Green Approach for Cathode Recycling of Li‐Ion Batteries

Promising Technological and Industrial Applications of Deep Eutectic Systems

Selected Monocyclic Monoterpenes and Their Derivatives as Effective Anticancer Therapeutic Agents

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