Abstract:Shikonin and its derivatives are excellent representatives of biologically active naphthoquinones. A wide range of investigations carried out in the last few decades validated their pharmacological efficacy. Besides having magnificent therapeutic potential, shikonin and its derivatives suffer from various pharmacokinetic, toxicity and stability issues like poor bioavailability, nephrotoxicity, photodegradation, etc. In the recent past, various research groups have developed an extensive range of formulations t… Show more
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