Formulation, physicochemical evaluation and antimicrobial activity of green toothpaste on streptococcus mutans

Abstract

<jats:p>Background: Toothpaste is a cosmetic product with increasing relevance and demand. However most commercial toothpaste consist of complex chemicals whose health safety remain unclear.Objectives: The present work involves the formulation, and comparative physicochemical evaluation and antimicrobial activity of green toothpaste and three commercial toothpastes (Close-Up, Oral-B and Dabur-Herbal)Methods: The green toothpaste were formulated using Tumeric (Curcuma longa), Aloe Vera (Aloe barbadensis miller), Guava (Psidium guajava), Mint (Mentha piperita), Neem (Azadirachta indica), and Lemon (Citrus lemon) as the active ingredients and comparatively evaluated for various properties like colour, taste, odor, texture, abrasivity, spreadability, cleansing ability, foaming ability, stability, homogeneity, moisture content, gritty matter and pH. The antimicrobial activity of the formula was comparatively tested on Streptococcus mutans (the major causative organism of dental caries).Results: Cold extracts of plant materials with ethanol showed a relative low (3.6% - 6.8%) percentage recovery of bioactive compounds. Physico-chemical tests revealed that the spreadability, pH, foam, gritty matter and homogeneity gave favourable results that compares well with commercial ones. The result of the antimicrobial test shows significant difference between the mean zones of inhibition of the various toothpastes.Conclusion: The results of the study agree with traditional application of the herbaceous plants and showed that the formulated toothpaste contains phytochemicals which possess antimicrobial properties and may be safer compared to toothpaste consisting of synthetic chemicals. </jats:p>

Evaluation of the Biological Efficacy and Physicochemical Evaluation of Toothpaste Prepared from Few Types of Plant Extracts against Some Pathogenic Bacteria Isolated from the Mouth

“…The number of scratches was determined and rated on a scale from 0 to 5 (no scratches). 4 Homogeneity Marketed as a uniform distribution in the cream confirmed by visual appearance and tactile production laboratory scale. 11…”

“…Then glycerin and soaked acacia were added to the above mixture, then this solution was added by drop to a blender containing herbal ingredients and crushed well until a paste consistency is formed, as shown in Figure 1. 4 Antimicrobial Evaluation of Toothpaste Three conventional toothpastes and the formulated toothpaste were selected, conducting prepared toothpaste tests and evaluation criteria. The inhibitory effect on bacterial isolates was studied as follows:…”

Formulation and Physicochemical Evaluation of a Herbal Dentifrice Formulated with Myristica fragrans (Nutmeg): An In Vitro Study

“…Organoleptic parameters including the colour, texture, appearance, taste and odour were evaluated by sensory and visual inspection of both the toothpastes. (10) pH levels 10 g of each toothpaste was dissolved in 10 ml of deionised water and stirred well to make a suspension in a 100 ml beaker. The pH was then measured using an EI pH meter.…”

“…The pH was then measured using an EI pH meter. (10) Foaming ability 5 g of each toothpaste was weighed into a 100 ml glass beaker. 10 ml of distilled water was added to it and allowed to stand for 30 minutes (allowing the toothpaste to disperse in the water).…”

“…The number and intensity of scratches that appeared on the butter paper was recorded as being absent or present. (10)…”