Formulation optimization of photocrosslinked polyacrylic acid modified with 2-hydroxyethyl methacrylate hydrogel as an adhesive for a dermatological patch

Onuki, Yoshinori; Hoshi, Masaru; Okabe, Hideaki; Fujikawa, Mikito; Morishita, Mariko; Takayama, K.

doi:10.1016/j.jconrel.2005.08.022

Cited by 51 publications

(57 citation statements)

References 25 publications

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“…The application as wound dressing and electrically conductive pads was also reported [50]. These types of hydrophilic PSAs consisting of swollen polymers require a chemical or photo cross-linking to increase their very low creep resistance [51,52]. Very few investigations deal with alternative strategies in order to avoid a final curing, which could determine a physical or chemical instability of the loaded drugs.…”

Section: Psas Used In Pharmaceutical Fieldmentioning

confidence: 99%

Adhesive properties: a critical issue in transdermal patch development

Cilurzo

Gennari

Minghetti

2011

Expert Opinion on Drug Delivery

112

106

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Section: Psas Used In Pharmaceutical Fieldmentioning

confidence: 99%

Adhesive properties: a critical issue in transdermal patch development

Cilurzo

Gennari

Minghetti

2011

Expert Opinion on Drug Delivery

112

106

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“…Swelling and gel fraction studies: Swelling and gel fraction studies were carried out on the basis of a previously reported literature [42]. Briefly, 0.1 g GG and TCG was weighed and placed in small dishes, which were carefully inserted into the glass flasks.…”

Section: Experimental Designmentioning

confidence: 99%

Development of novel thiolated carboxymethyl-gellan gum as potential mucoadhesive polymer: Application of DoE

More¹,

Bhamare²,

Bhavsar³

et al. 2017

Adv Mater Sci

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The objective of the present investigation was to synthesize soluble carboxymethyl-gellan gum (CMG) from gellan gum (GG) using statistical experimental design (DoE) strategy. Experimental design can potentially calculate the optimum reaction condition required to obtain response i.e. degree of substitution (DS) of CMG, which was statistically assessed. The effect of two process factors, namely concentration of monochoroacetic acid and water:isopropanol ratio on DS was investigated. Another objective of present study was to improve the mucoadhesive strength of optimized CMG by its covalent attachment with thiol moieties so as to get thiolated carboxymethyl-gellan gum (TCG). Synthesized CMG and TCG were characterized by FT-IR, DSC and NMR. Polymer compacts of TCG exhibited 3.73 fold greater adhesive strength on goat intestinal mucosa as compared with bare GG. In accordance with the promising results obtained; synthesized TCG can be considered as potential modified polymer for further drug delivery applications, especially mucoadhesive systems.

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“…Sonuçta PEG-DA makromer; EGDMA çapraz bağlayıcı; DMPA fotobaşlatıcı ve distile su varlığında hidrojel sentezi gerçekleştirilmiştir. Çapraz bağlayıcı oranı arttıkça elde edilen hidrojellerin daha sert ve mekanik olarak daha dirençli oldukları ve ağırlıkça makromer oranının artmasıyla çapraz bağlayıcı oranının hidrojelin mekanik direncine olan etkisinin daha fazla olduğu gözlenmiştir [17][18][19][20].…”

Section: Hidrojel Senteziunclassified

“…Şişme yüzdeleri P302 hidrojeli için %131; P312 hidrojeli için %173 ve P332 hidrojeli için %164'tür. Bu durum yüksek DMPA miktarı çok miktarda serbest radikal oluş-turduğu ve böylece polimerizasyon reaksiyonu daha hızlı bir şekilde yürüdüğü şeklinde yorumlanmıştır [18][19][20][21][22].…”

Section: Hidrojellerin Dinamik şIşme Davranışlarıunclassified

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Photocrosslinked Poly(Ethylen Glycol) Hydrogels for Controlled Drug Delivery

Ayhan¹

2014

Turk J Bioch

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Objective: In the work presented, synthesis of PEG based hydrogels, characterization of synthesized hydrogels and usage of these hydrogels in controlled drug release systems were studied. Methods: Synthesis of PEG based hydrogels having different properties was done by free radical photopolymerization by using a photoinitiator . In this stage because of their biocompatibility, poly ethylene glycol Diacrylate (PEG-DA) as macromer; ethylene glycol dimetacrylate (EGDMA) as cross-linker and 2,2 dimetoxy-2 phenylacetophenon (DMPA) as photoinitiator were used. The macromer amounts of 30, 50 and 100%, cross-linker ratio of 0.25, 1.0 and 3% and photoinitiator ratio of 0.1, 0.5 and 1% by weight were selected. In this scope, dynamic swelling behaviour of hydrogels and their suitability for controlled drug release were tested. The surface characterization of the hydrogels was performed by Attenuated Total Reflectance-Fourier Transfer Infrared Spectroscopy (ATR-FTIR) spectrums. The drug release experiments of dry polymer disks with known weight and known loaded drug amount were performed in pH 7.4 and 1.2 buffer solutions with set ionic strengths, in shaking incubator at 37°C constant temperature with a shaking speed of 100 rpm. In the last part of the work, drug activities of synthesized drug-loaded hydrogels were tested in Staphylococcus aureus and Pseudomonas aeruginosa bacteria cultures. Results: A decrease in swelling degree of hydrogel was observed with an increase in macromer ratio. In the ATR-FTIR spectrums, O-H tension, C-H tension, C=O tension, C-O tension vibration bands which can be said to be a characteristic of PEG-DA hydrogels were observed. The rate of drug release in pH 1.2 was observed to be much faster than pH 7.4 for both types of hydrogels. The transport mechanism in hydrogels was determined by a widely used semi-empirical formula. It was observed that selected drug-loaded hydrogels were effective on inhibition of the reproduction of both bacteria. Conclusion: In the work presented, all of the hydrogels synthesized were found compatible for the controlled drug delivery. Key Words: Photopolymerization, hydogels, controlled drug delivery; PEG. Conflict of Interest:The authors declare no conflict of interest. ÖZETAmaç: Sunulan araştırma kapsamında; PEG bazlı hidrojellerin sentezi, elde edilen hidrojellerin karakterizasyonu ve bu hidrojellerin kontrollü ilaç salım sistemlerinde kullanımlarının incelenmesi amaçlanmıştır. Metod: Farklı özelliklere sahip PEG bazlı hidrojellerin fotopolimerizasyon yöntemi ile fotobaşlatıcı kullanılarak serbest-radikal fotopolimerizasyonuyla sentezi gerçekleştirilmiştir. Bu aşamada yüksek biyouyumluluğu nedeniyle poli(etilenglikol) diakrilat (PEGDA) makromeri; çapraz bağlayıcı olarak etilen glikol dimetakrilat (EGDMA), fotobaşlatıcı olarak ise 2,2-dimetoksi-2-fenilasetofenon (DMPA) kullanılmıştır. Makromer oranı ağırlıkça %30, 50 ve 100; çapraz bağlayıcı oranı ağırlıkça %0.25, 1.0, 3.0; fotobaşlatıcı oranı ağırlıkça %0.1, 0.5 ve 1 değerlerinde değiştirilerek bileşen mikt...

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Formulation optimization of photocrosslinked polyacrylic acid modified with 2-hydroxyethyl methacrylate hydrogel as an adhesive for a dermatological patch

Cited by 51 publications

References 25 publications

Adhesive properties: a critical issue in transdermal patch development

Adhesive properties: a critical issue in transdermal patch development

Development of novel thiolated carboxymethyl-gellan gum as potential mucoadhesive polymer: Application of DoE

Photocrosslinked Poly(Ethylen Glycol) Hydrogels for Controlled Drug Delivery

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