Formulation, Optimization and In Vitro Evaluation of Fast Disintegrating
Tablets of Salbutamol Sulphate using a Combination of Superdisintegrant
and Subliming Agent

Ejeta, Fikadu; Gabriel, Tesfaye; Joseph, Nisha Mary; Belete, Anteneh

doi:10.2174/1567201818666210614094646

Cited by 21 publications

(12 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among them, polymeric excipients are the main stream [ 19 , 20 , 21 , 22 ]. On the other hand, new materials processing and treatment methods, particularly nanotechnologies, are continuously explored for encapsulating drugs into pharmaceutical excipients for increasing their therapeutic effects [ 23 , 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release

et al. 2022

View full text Add to dashboard Cite

One of the most important trends in developments in electrospinning is to combine itself with traditional materials production and transformation methods to take advantage of the unique properties of nanofibers. In this research, the single-fluid blending electrospinning process was combined with the casting film method to fabricate a medicated double-layer hybrid to provide a dual-phase drug controlled release profile, with ibuprofen (IBU) as a common model of a poorly water-soluble drug and ethyl cellulose (EC) and polyvinylpyrrolidone (PVP) K60 as the polymeric excipients. Electrospun medicated IBU-PVP nanofibers (F7), casting IBU-EC films (F8) and the double-layer hybrid films (DHFs, F9) with one layer of electrospun nanofibers containing IBU and PVP and the other layer of casting films containing IBU, EC and PVP, were prepared successfully. The SEM assessments demonstrated that F7 were in linear morphologies without beads or spindles, F8 were solid films, and F9 were composed of one porous fibrous layer and one solid layer. XRD and FTIR results verified that both EC and PVP were compatible with IBU. In vitro dissolution tests indicated that F7 were able to provide a pulsatile IBU release, F8 offered a typical drug sustained release, whereas F9 were able to exhibit a dual-phase controlled release with 40.3 ± 5.1% in the first phase for a pulsatile manner and the residues were released in an extended manner in the second phase. The DHFs from a combination of electrospinning and the casting method pave a new way for developing novel functional materials.

show abstract

Section: Introductionmentioning

confidence: 99%

Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release

et al. 2022

View full text Add to dashboard Cite

show abstract

“…80 However, most NSAIDs have poor water solubility and cannot be fully utilized in periodontal treatment. At present, various methods, including solid-dispersible tablets [81][82][83][84][85][86][87] and nano-hybrids, 27,46 have been developed to speed up the dissolution rate. In The higher the relative molecular weight, the larger the fiber diameter, and the smoother the fiber without beads.…”

Section: Single-fluid Electrospinningmentioning

confidence: 99%

Electrospun Nanofibers for Periodontal Treatment: A Recent Progress

Zhao¹,

Chen²,

Feng³

et al. 2022

IJN

View full text Add to dashboard Cite

Periodontitis is a major threat to oral health, prompting scientists to continuously study new treatment techniques. The nanofibrous membrane prepared via electrospinning has a large specific surface area and high porosity. On the one hand, electrospun nanofibers can improve the absorption capacity of proteins and promote the expression of specific genes. On the other hand, they can improve cell adhesion properties and prevent fibroblasts from passing through the barrier membrane. Therefore, electrospinning has unique advantages in periodontal treatment. At present, many oral nanofibrous membranes with antibacterial, anti-inflammatory, and tissue regeneration properties have been prepared for periodontal treatment. First, this paper introduces the electrospinning process. Then, the commonly used polymers of electrospun nanofibrous membranes for treating periodontitis are summarized. Finally, different types of nanofibrous membranes prepared via electrospinning for periodontal treatment are presented, and the future evolution of electrospinning to treat periodontitis is described.

show abstract

“…[19][20][21][22] Particularly, the fast or pulsatile release, one type of ratecontrolled release profile (Figure 1), has the advantages of rapid release for achieving a rapid therapeutic action for many diseases such as fever, aches, and emotional irritability. [23][24][25] During the past three decades, the giant progress of nanoscience and nanotechniques has provided many useful strategies for enhancing the dissolution and effective delivery of poorly water-soluble drugs. [26][27][28] Nanoparticles, nanofibers, nanofilms, nanoemulsions, solid lipid nano vessels of poorly water-soluble drugs are reported every day and many of them have successfully walked into the commercial markets for benefiting people's healthy lives.…”

Section: Introductionmentioning

confidence: 99%

“…[ 19–22 ] Particularly, the fast or pulsatile release, one type of rate‐controlled release profile ( Figure ), has the advantages of rapid release for achieving a rapid therapeutic action for many diseases such as fever, aches, and emotional irritability. [ 23–25 ]…”

Section: Introductionmentioning

confidence: 99%

Three EHDA Processes from a Detachable Spinneret for Fabricating Drug Fast Dissolution Composites

Chen,

Zhou,

Fang

et al. 2023

Macro Materials & Eng

View full text Add to dashboard Cite

In this study, three kinds of electrohydrodynamic atomization (EHDA) processes (electrospraying, electrospinning, and coaxial electrospinning) are implemented to create hydroxypropyl methylcellulose (HPMC) based ultra‐thin products for providing the fast dissolution of a poorly water‐soluble drug ketoprofen (KET). An EHDA apparatus, characterized by a novel spinneret, is homemade for conducting the three processes. The three types of products are electrospun nanofibers E1, electrosprayed microparticles E2, and core‐shell nanofibers E3. SEM and TEM results indicate that they have the anticipated morphologies and inner structures. X‐ray diffraction and Fourier Transform Infrared results verify that KET is mainly amorphous in all the composites due to its fine compatibility with HPMC. In vitro dissolution tests demonstrate that the drug rapid release performances has an order of E3>E1>E2≫KET powders. The fast dissolution mechanisms are suggested and the advantages of the three products are compared. The super performance of E3 in furnishing the rapid release is attributed to a synergistic action of small size (of the shell thickness), high porosity, amorphous state of drug, and the solubility of HPMC. EHDA nanostructures can support the development of nano drug delivery systems (DDSs) through tailoring the spatial distribution of drug molecules within the nano products.

show abstract

Formulation, Optimization and In Vitro Evaluation of Fast Disintegrating Tablets of Salbutamol Sulphate using a Combination of Superdisintegrant and Subliming Agent

Cited by 21 publications

References 38 publications

Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release

Hybrid Films Prepared from a Combination of Electrospinning and Casting for Offering a Dual-Phase Drug Release

Electrospun Nanofibers for Periodontal Treatment: A Recent Progress

Three EHDA Processes from a Detachable Spinneret for Fabricating Drug Fast Dissolution Composites

Contact Info

Product

Resources

About