Formulation, Optimization and Evaluation of Aceclofenac Transdermal Gel: A Novel Approach for Penetration Enhancement by Herbal Extract

Abstract

The present research has been undertaken with the ambition to formulate, optimize and evaluate the gel containing Eugenia caryophyllus oil. The gel formulation was designed by using oil which obtained from the leaves of Eugenia caryophyllus. The gel was prepared by using aceclofenac (API) and optimum ratio of carbopol 941 P and HPMC K15M and other excipients are propylene glycol, triethanolamine, and methyl paraben. The Eugenia caryophyllus oil was used as a penetration enhancer. All prepared gel formulations were evaluated by pH, spredability, extrudability, viscosity, drug contents, in-vitro permeability studies and drug-polymer compatibility (FTIR studies). The absorption maxima of aceclofenac were found at 273 nm using pH 6.8 phosphate buffer solutions. The pH values of all formulation was in the range between 6.81 -7.13. Drug content of all formulation ranges from 82.00 -88.89%. The result value of spreadability was range from 11.00 -14.00(gm. cm / sec). Whereas the extrudability value of gel formulations from the collapsible tube varies range from 160.00 to 222.22 (gm.cm 2 ) and the viscosity of formulations ranges from 18554 cps to 20782 cps at 50 rpm. The % cumulative drug release range from 42.52 -63.02% in 6 hr.

Formulation development of anti-rheumatoid gel of Saraca asoca (Roxb.) De Wilde hydroalcoholic extract containing eucalyptus oil and peppermint oil as penetration enhancer

“…Eight batches of S. asoca gel formulations were subjected to drug release studies using egg membrane with a permeation area of 5.12 cm 2 . 55 ml of phosphate buffer (pH 7.4) was taken in receptor compartment, and then 2 g of gel was applied on membrane (Singh et al, 2015). The donor phase was kept in contact with receptor phase and the temperature was maintained at 37±0.1°C (Goyal et al, 2011).…”

In vitro Evaluation of the Effect of Using Different Gelling agents on the Release of Erythromycin from a Nanocubosomal gel

“…A sample of 0.5 g of each formula (FG1-FG8) was placed between two glass slides then a 0.5 Kg weight was applied and left for approximately 5 minutes when no further spreading was expected. Diameters of spread circles were marked and measured in centimeter (cm) and compared with the initial circle diameter (diameter of the spread circle that has been made without the use of the weight) [13,14] .…”