Formulation of plumbagin-loaded microemulsion: Evaluation of anti-rheumatoid efficacy in Wistar rat model

Khichariya, Ajita; Jeswani, Gunjan; Choudhary, Rajesh; Alexander, Amit; Nakhate, Kartik T.; Badwaik, Hemant

doi:10.1016/j.molliq.2022.119851

Cited by 14 publications

(4 citation statements)

References 47 publications

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“…In order to identify the oils with the greatest ability to solubilize TZR, a solubility study was conducted, which will lead to a bigger ME area in the pseudo-ternary plots ( Khichariya et al, 2022 ). The choice of oil in ME is a crucial stage since it influences the size of the globules, the amount of drug loaded, and the amount of surfactant/cosurfactant needed to create a stable ME ( Khichariya et al, 2022 ). Fig.…”

Section: Resultsmentioning

confidence: 99%

Tackling acne vulgaris by fabrication of tazarotene-loaded essential oil-based microemulsion: In vitro and in vivo evaluation

Badawi

Yehia

Lamie

et al. 2023

International Journal of Pharmaceutics: X

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Section: Resultsmentioning

confidence: 99%

Tackling acne vulgaris by fabrication of tazarotene-loaded essential oil-based microemulsion: In vitro and in vivo evaluation

Badawi

Yehia

Lamie

et al. 2023

International Journal of Pharmaceutics: X

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“…The skin structure is illustrated in Figure 3. [54,59,[67][68][69]. ZP values greater than ±30 mV indicate excellent stability [65].…”

Section: Human Skin Structurementioning

confidence: 99%

“… Zeta potential (ZP) is utilized to predict colloidal dispersion stability, with its value dependent on pH, ionic strength, and particle concentration. ZP measurement is common for o/w MEs; however, some studies have reported ZP values for w/o MEs [ 54 , 59 , 67 , 68 , 69 ]. ZP values greater than ±30 mV indicate excellent stability [ 65 ].…”

Section: Introductionmentioning

confidence: 99%

Topical Microemulsions: Skin Irritation Potential and Anti-Inflammatory Effects of Herbal Substances

Leanpolchareanchai

Teeranachaideekul

2023

Pharmaceuticals

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Microemulsions (MEs) have gained prominence as effective drug delivery systems owing to their optical transparency, low viscosity, and thermodynamic stability. MEs, when stabilized with surfactants and/or co-surfactants, exhibit enhanced drug solubilization, prolonged shelf life, and simple preparation methods. This review examines the various types of MEs, explores different preparation techniques, and investigates characterization approaches. Plant extracts and bioactive compounds are well established for their utilization as active ingredients in the pharmaceutical and cosmetic industries. Being derived from natural sources, they serve as preferable alternatives to synthetic chemicals. Furthermore, they have demonstrated a wide range of therapeutic effects, including anti-inflammatory, antimicrobial, and antioxidant activities. However, the topical application of plant extracts and bioactive compounds has certain limitations, such as low skin absorption and stability. To overcome these challenges, the utilization of MEs enables enhanced skin absorption, thereby making them a valuable mode of administration. However, considering the significant surfactant content in MEs, this review evaluates the potential skin irritation caused by MEs containing herbal substances. Additionally, the review explores the topical application of MEs specifically for herbal substances, with an emphasis on their anti-inflammatory properties.

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“…Plants are the major sources of natural antioxidant and anti-inflammatory phytomedicines [107,108]. Phloretin displays these activities and, hence, can be used for the management of oxidative stress and inflammatory degenerative disease [26,109,110].…”

Section: Anti-inflammatory and Antioxidant Activitiesmentioning

confidence: 99%

Therapeutic Potential and Pharmaceutical Development of a Multitargeted Flavonoid Phloretin

Nakhate

Badwaik²,

Choudhary³

et al. 2022

Nutrients

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Phloretin is a flavonoid of the dihydrogen chalcone class, present abundantly in apples and strawberries. The beneficial effects of phloretin are mainly associated with its potent antioxidant properties. Phloretin modulates several signaling pathways and molecular mechanisms to exhibit therapeutic benefits against various diseases including cancers, diabetes, liver injury, kidney injury, encephalomyelitis, ulcerative colitis, asthma, arthritis, and cognitive impairment. It ameliorates the complications associated with diabetes such as cardiomyopathy, hypertension, depression, memory impairment, delayed wound healing, and peripheral neuropathy. It is effective against various microbial infections including Salmonella typhimurium, Listeria monocytogenes, Mycobacterium tuberculosis, Escherichia coli, Candida albicans and methicillin-resistant Staphylococcus aureus. Considering the therapeutic benefits, it generated interest for the pharmaceutical development. However, poor oral bioavailability is the major drawback. Therefore, efforts have been undertaken to enhance its bioavailability by modifying physicochemical properties and molecular structure, and developing nanoformulations. In the present review, we discussed the pharmacological actions, underlying mechanisms and molecular targets of phloretin. Moreover, the review provides insights into physicochemical and pharmacokinetic characteristics, and approaches to promote the pharmaceutical development of phloretin for its therapeutic applications in the future. Although convincing experimental data are reported, human studies are not available. In order to ascertain its safety, further preclinical studies are needed to encourage its pharmaceutical and clinical development.

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Formulation of plumbagin-loaded microemulsion: Evaluation of anti-rheumatoid efficacy in Wistar rat model

Cited by 14 publications

References 47 publications

Tackling acne vulgaris by fabrication of tazarotene-loaded essential oil-based microemulsion: In vitro and in vivo evaluation

Tackling acne vulgaris by fabrication of tazarotene-loaded essential oil-based microemulsion: In vitro and in vivo evaluation

Topical Microemulsions: Skin Irritation Potential and Anti-Inflammatory Effects of Herbal Substances

Therapeutic Potential and Pharmaceutical Development of a Multitargeted Flavonoid Phloretin

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