Formulation of nitrendipine/hydroxypropyl-β-cyclodextrin inclusion complex as a drug delivery system to enhance the solubility and bioavailability by supercritical fluid technology

Liang, Bingchan; Hao, Jianxia; Zhu, Nianyong; Han, Limin; Song, Liang; Hong, Hailong

doi:10.1016/j.eurpolymj.2023.111880

European Polymer Journal

2023

DOI: 10.1016/j.eurpolymj.2023.111880

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Formulation of nitrendipine/hydroxypropyl-β-cyclodextrin inclusion complex as a drug delivery system to enhance the solubility and bioavailability by supercritical fluid technology

Bingchan Liang

Jianxia Hao

Nianyong Zhu

et al.

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Cited by 5 publications

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Inclusion Complexation of Flavonoids with Cyclodextrin: Molecular Docking and Experimental Study

Ming Liu,

Yun Zhou,

Qiang Jiang

et al. 2024

ChemistrySelect

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In our work, the inclusion ability and binding pattern of flavonoids (catechin, iso‐liquiritigenin, luteolin, puerarin, rutin, and curcumin) with β‐cyclodextrin (β‐CD) and curcumin (CUR) with CDs (α‐CD, β‐CD, γ‐CD, dimethyl‐β‐CD, Hydroxypropyl‐β‐CD, and glucosyl‐β‐CD) were studied by molecular docking. The results showed that CUR among the six flavonoids was more likely to form stable inclusion complexes with β‐CD, and the HP‐β‐CD is the most suitable for CUR inclusion among the 6 types of CD. Phase solubility studies showed that CUR with β‐CD or HP‐β‐CD, respectively, could form stable inclusion complexes in a stoichiometric ratio of 1 : 1. The CUR/β‐CD and CUR/HP‐β‐CD inclusion complexes (ICs) were prepared by freeze‐drying method. The successful preparation of IC was confirmed by SEM images, FT‐IR spectra, and TG‐DSC. The results of in vitro release showed that the release of CUR from IC prepared with β‐CD or HP‐β‐CD could be improved significantly, and the release effect of HP‐β‐CD was better than that of β‐CD. The inclusion with CD could be used to improve the solubility and bioavailability of CUR.

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Inclusion Complexation of Flavonoids with Cyclodextrin: Molecular Docking and Experimental Study

Ming Liu,

Yun Zhou,

Qiang Jiang

et al. 2024

ChemistrySelect

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Thermodynamic study for the (butyl, hexyl and octyl) acetoacetate under high pressure CO2

Byun,

Ghoderao,

Lee

et al. 2023

Arabian Journal of Chemistry

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Pharmacokinetics and pharmacodynamics of cyclodextrin-based oral drug delivery formulations for disease therapy

Liu,

Guo,

Wei

et al. 2024

Carbohydrate Polymers

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Formulation of nitrendipine/hydroxypropyl-β-cyclodextrin inclusion complex as a drug delivery system to enhance the solubility and bioavailability by supercritical fluid technology

Cited by 5 publications

References 42 publications

Inclusion Complexation of Flavonoids with Cyclodextrin: Molecular Docking and Experimental Study

Inclusion Complexation of Flavonoids with Cyclodextrin: Molecular Docking and Experimental Study

Thermodynamic study for the (butyl, hexyl and octyl) acetoacetate under high pressure CO2

Pharmacokinetics and pharmacodynamics of cyclodextrin-based oral drug delivery formulations for disease therapy

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