Formulation of Eco-friendly Medicated Chewing Gum to Prevent Motion Sickness

Abstract

ABSTRACT. An attempt was made to formulate medicated chewing gum to prevent motion sickness using natural gum base for faster onset of action and easy administration, anywhere and anytime, without access to water. To avoid the discard issue of gum cud, natural gum base of Triticum aestivum (wheat grain) was explored because of its biodegradable and biocompatible nature and easy availability. Prolamin, extracted from wheat, showed good chewing capacity, elasticity, high water retention capacity, antifungal activity, and compatibility with the drug. Formulations were prepared based on a two-factor and three-level factorial design. Amount of calcium carbonate (texturizer) and gum base were selected as independent variables. Elasticity and drug release were considered as the dependent variables. All batches were evaluated for the content uniformity, elasticity study, texture study, in vitro drug release study, and chewiness study. Results revealed that medicated chewing gum containing 80 mg of calcium carbonate and 500 mg of gum base showed good elasticity and more than 90% drug release within 16 min. Thus, this study suggested that both good elasticity and chew ability and abundant availability of wheat grain can act as a potential gum base for medicated chewing gum.

Development of a Chewing Robot With Built-in Humanoid Jaws to Simulate Mastication to Quantify Robotic Agents Release From Chewing Gums Compared to Human Participants

“…Previous in vitro work investigating the release of substances from medicated chewing gums has involved techniques varying from the two instruments, recognised by the European Pharmacopoeia, known as apparatus A and B [19], [24]- [25], [95], to the use of a pestle and mortar to pound the chewing gum in solution releasing the agent of interest [96]. When analysing these methods it was clear that the human physiological features with mechanics of mastication and six degrees of freedom that are possible with human mastication were not accounted for limiting their applicability to modeling MCG drug release from chewing.…”

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“…Chewing gum incorporated with various types of active ingredients is one such example of novel drug delivery. Medicated chewing gum (MCGs) is effective locally as well as systemically in dental caries, smoking cessation 28 , pain, obesity, acidity, allergy, nausea, motion sickness 21,22 , diabetes, anxiety, dyspepsia, osteoporosis, cough, common cold, etc. 16,17,18,19 .…”

“…The in-vitro drug release data revealed that MCG-II shows better drug release than other formulations. MCG -II formulation was considered to be an optimized formula that consists of synthetic gum base (60%), Liquid Glucose (20%), sucrose (15%) which shows more drug release in the phosphate buffer (pH 6.8) 21 . The cumulative drug release of MCG-II formulation was found to be 99.43%.…”

Investigating release kinetics of phenolics from defatted wheat germ incorporated chewing gums

“…Therefore, nowadays it can be stated that there are various food products that have improved their functional properties in the sectors, such as dairy, cereal, and meat products, different beverages, candies, cookies, pastries and baby foods . In this regard, the studies carried out with the aim of providing functionality to chewing gum have recently gained momentum . Since, chewing gum has many advantages in terms of targeted delivery of healthy ingredients without taking excess calories.…”

“…3,4 In this regard, the studies carried out with the aim of providing functionality to chewing gum have recently gained momentum. 5,6 Since, chewing gum has many advantages in terms of targeted delivery of healthy ingredients without taking excess calories. For instance, it has a fast effect after absorption through the buccal and sublingual mucosal and from the gastrointestinal tract.…”