Formulation of a solid intravaginal matrix system to prolong the pH-decreasing effect of lactic acid

Baki, Gabriella; Bajdik, János; Kelemen, András; Pintye‐Hódi, Klára

doi:10.1016/s1773-2247(09)50021-4

Cited by 3 publications

(1 citation statement)

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“…Most methods used are designed to mimic the general conditions encountered in the physiological environment of the vagina, including the pH of the dissolution solvent and maintaining a temperature of 37 ± 1°C during testing. A total of 72% from the reviewed studies have specified the pH of the dissolution medium used and the mean pH was 4.7, which is within the range of the pH of the vaginal fluid (pH 4-5) (46,47).…”

Section: Drug Release Assessmentmentioning

confidence: 99%

A systematic review of mucoadhesive vaginal tablet testing

Abidin

Murphy

Fehrenbach

et al. 2023

dti

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Drug administration through the vaginal tract is one of the oldest modalities of pharmacotherapy, and it is also one of the most explored. Since the vaginal cavity has a wide surface area, a plentiful blood supply, and a complexnetwork of blood arteries, it can evade hepatic first-pass metabolism and obtain high local drug concentrations.Vaginal pills look to be a good dose form since they are simple to use, portable, and can easily deliver therequired amount of medicine. Vaginal formulations, on the other hand, are vulnerable to rapid expulsion due tothe vaginal tract’s self-cleaning action, which reduces the formulation’s efficiency. Currently, there is an increasingamount of focus on mucoadhesive vaginal formulation research and development to fix the formulation at theplace where the medicine can be released and/or absorbed. This article examines all of the strategies used byresearchers to develop a mucoadhesive vaginal tablet that is safe, effective, and comfortable for the user.

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Section: Drug Release Assessmentmentioning

confidence: 99%