Formulation, <i>in-vitro</i> characterization and clinical evaluation of curcumin <i>in-situ</i> gel for treatment of periodontitis

Nasra, Maha M A; Khiri, Heba M.; Hazzah, Heba A.; Abdallah, Ossama Y.

doi:10.1080/10717544.2016.1233591

Cited by 81 publications

(55 citation statements)

References 22 publications

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“…However, the accidental swallowing of the formulations besides continuous dilution by saliva allow for only a short drug residence time in the oral cavity [ 162 ]. The mucoadhesive poloxamer 407-based gel systems were also used in this case to establish strong contact with the buccal mucosa, increasing the residence time of the contained drugs and improving their bioavailability [ 163 , 164 , 165 ]. For example, Nasra et al developed a poloxamer 407-based hydrogel for the buccal delivery of curcumin, with the aim of exploiting the anti-inflammatory properties of the substance to decrease the inflammatory mediators involved in periodontitis [ 164 ].…”

Section: Poloxamer 407-based Mucoadhesive Formulationsmentioning

confidence: 99%

Mucosal Applications of Poloxamer 407-Based Hydrogels: An Overview

et al. 2018

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Poloxamer 407, also known by the trademark Pluronic® F127, is a water-soluble, non-ionic triblock copolymer that is made up of a hydrophobic residue of polyoxypropylene (POP) between the two hydrophilic units of polyoxyethylene (POE). Poloxamer 407-based hydrogels exhibit an interesting reversible thermal characteristic. That is, they are liquid at room temperature, but they assume a gel form when administered at body temperature, which makes them attractive candidates as pharmaceutical drug carriers. These systems have been widely investigated in the development of mucoadhesive formulations because they do not irritate the mucosal membranes. Based on these mucoadhesive properties, a simple administration into a specific compartment should maintain the required drug concentration in situ for a prolonged period of time, decreasing the necessary dosages and side effects. Their main limitations are their modest mechanical strength and, notwithstanding their bioadhesive properties, their tendency to succumb to rapid elimination in physiological media. Various technological approaches have been investigated in the attempt to modulate these properties. This review focuses on the application of poloxamer 407-based hydrogels for mucosal drug delivery with particular attention being paid to the latest published works.

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Section: Poloxamer 407-based Mucoadhesive Formulationsmentioning

confidence: 99%

Mucosal Applications of Poloxamer 407-Based Hydrogels: An Overview

et al. 2018

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“…The ability of the samples (HSA/oil, PX/HSA/oil, and DFA/HSA/oil) in the presence of 4 wt% ethanol to easily flow through a syringe with a 21 gauge needle was evaluated using previously described methods . Within 15 min, 3 mL of the samples that was cooled to 25 °C was filled into a 21 gauge needle syringe.…”

Section: Methodsmentioning

confidence: 99%

A Supramolecular Gel Based on 12‐Hydroxystearic Acid/Virgin Coconut Oil for Injectable Drug Delivery

Tantishaiyakul

Ouiyangkul

Wajasat

et al. 2018

Euro J Lipid Sci & Tech

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A supramolecular organogel based on 3 wt% of 12‐hydroxystearic acid (HSA) and virgin coconut oil (oil) in the presence of a gel inhibitor, 4 wt% ethanol (EtOH), is developed and investigated for injectable implant delivery. Gel formation is observed by the test tube tilting method. The characteristic properties of the sol‐gel system are determined using rheological, thermal, and turbidity analyses. The in vitro releases of piroxicam (PX) and diclofenac acid (DFA), the models for hydrophilic and lipophilic drugs, respectively, are performed. Characterization of the blends from the three methods are comparable and indicate that the systems of HSA/oil, PX/HSA/oil, and DFA/HSA/oil gel at about 36–39 °C upon cooling and the gel turns to a sol at a temperature higher than 50 °C upon heating at a rate of 2 °C min−1. Isothermal measurements reveals that HSA/EtOH/oil, PX/HSA/EtOH/oil, and DFA/HSA/EtOH/oil remain as a sol for about 18 min at room temperature (25 °C). Both PX and DFA show a sustained release from HSA/oil and HSA/EtOH/oil. Practical Applications: The presence of ethanol which is a hydrophilic molecule can disrupt the interaction between HSA molecules and suppress gel formation at the low temperature that the system normally forms gel. This HSA/EtOH/oil system might be injectable at room temperature and become gels at the site of injection when EtOH is diffused to other tissues in the body. This system is beneficial for use as an injectable implant system for a sustained delivery of both hydrophilic and hydrophobic drugs. 12‐hydroxystearic acid (HSA) and virgin coconut oil (oil) can form gels at body and lower temperatures e.g., room temperatures. The sol‐gel system is characterized using rheological, thermal, and turbidity methods. Ethanol inhibits gel formation at room temperature to facilitate injection. The mixture of HSA, ethanol, and oil might be used as an injectable implantation. Two hydrophobic (diclofenac) and hydrophilic (piroxicam) model drugs show sustained releases from HSA/oil and HSA/ethanol/oil.

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“…Nasra et al developed in situ gel formulations of curcumin using 30% of pluronic F127, and 1% of carbopol P934. The selected formulations delivered into the periodontal pocket were verified in clinical research [123]. Nanoparticles [38] and gels [139] DDS were also developed for local anti-inflammatory therapy, too.…”

Section: Inflammation Modulating and Alveolar Bone Repairing Dds For mentioning

confidence: 99%

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

et al. 2020

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The oral cavity is a unique complex ecosystem colonized with huge numbers of microorganism species. Oral cavities are closely associated with oral health and sequentially with systemic health. Many factors might cause the shift of composition of oral microbiota, thus leading to the dysbiosis of oral micro-environment and oral infectious diseases. Local therapies and dental hygiene procedures are the main kinds of treatment. Currently, oral drug delivery systems (DDS) have drawn great attention, and are considered as important adjuvant therapy for oral infectious diseases. DDS are devices that could transport and release the therapeutic drugs or bioactive agents to a certain site and a certain rate in vivo. They could significantly increase the therapeutic effect and reduce the side effect compared with traditional medicine. In the review, emerging recent applications of DDS in the treatment for oral infectious diseases have been summarized, including dental caries, periodontitis, peri-implantitis and oral candidiasis. Furthermore, oral stimuli-responsive DDS, also known as "smart" DDS, have been reported recently, which could react to oral environment and provide more accurate drug delivery or release. In this article, oral smart DDS have also been reviewed. The limits have been discussed, and the research potential demonstrates good prospects.Molecules 2020, 25, 516 2 of 29 problems. For example, systemic antibiotics such as tetracycline, beta-lactam antibiotics, nitroimidazoles have been used, especially in cases of periodontal diseases and peri-implantitis [12]. However, systemic antibiotics could cause problems like drug resistance, dysbacteriosis, and systemic side effects [13,14]. The antibacterial effect is also limited as very little could arrive at the oral lesion area after systemic circulation [15][16][17]. Fluoride in drinking water has been used for the prevention of dental caries but might cause excessive intake, leading to fluorosis [18]. Therefore, local drug therapy is now more considered for oral infectious diseases [19,20]. However, the conventional forms of local therapy, like drug suspension or rinse of anti-infection agents, could be easily washed off and thus could not last long in the oral cavity. Complex local lesions like deep periodontal pockets and teeth fissure are also difficult to reach. In order to improve the effect of prophylaxis and treatment, more precise targeting therapy is quite essential [21,22]. Therefore, drug delivery systems have drawn great attention in recent decades in oral infectious diseases. Drug delivery systems (DDS) are devices that can transport and release the therapeutic agents or bioactive substances to certain sites at certain rates in vivo [23,24], usually composed of the carriers and associated therapeutics [25]. They have been widely explored in biomedical research. With local drug administration and controlled drug release, DDS could provide higher curative efficiency and fewer side effects [23,26,27]. With all these advantages, DDS has been reported w...

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Formulation, in-vitro characterization and clinical evaluation of curcumin in-situ gel for treatment of periodontitis

Cited by 81 publications

References 22 publications

Mucosal Applications of Poloxamer 407-Based Hydrogels: An Overview

Mucosal Applications of Poloxamer 407-Based Hydrogels: An Overview

A Supramolecular Gel Based on 12‐Hydroxystearic Acid/Virgin Coconut Oil for Injectable Drug Delivery

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

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