Formulation, evaluation and release studies of Indomethacin Suppositories

Dewangan, Kalyani; Nagori, Kushagra; Sharma, Mukesh C.; Singh, Ajay; Chandrakar, Sandhya; Sahu, Vandana Devi; Sharma, Garima; Gupta, Sujata; Solanki, Harsha; Majumdar, Manisha; Tripathi, D. K.; Alexander, Amit; AJAZUDDIN, .

doi:10.5958/0974-360x.2016.00181.5

Cited by 4 publications

(3 citation statements)

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“…Comp-ounds featuring diverse ring systems such as pyridine [1][2][3], pyrimidine [4][5][6][7][8], pyrazole [9,10], pyrazoline-pyrazolone [11][12][13], among others [14][15][16][17][18], have long been investigated for their medicinal potential, serving as foundational elements for pharmacologically active drugs. Pyrazole derivatives have garnered significant attention globally due to their versatile applications spanning pharmaceuticals [19][20][21], agrochemistry [22][23][24][25][26][27] and various other industries. These compounds play a pivotal role in medicinal chemistry, serving as indispensable building blocks for innovative drug development [28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Path of Pyrazoles from Synthetic Factors to Anti-inflammatory Potential: A Review

Vashisht,

Sethi,

Bansal

et al. 2024

ajc

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Pyrazoles, a class of heterocyclic compounds, have garnered considerable attention in drug development due to their intriguing properties, particularly those containing a pyrazole moiety. Pyrazole, a pivotal chemical in the creation of potent bioactive agents, encompasses five heterocyclic members. The discovery of certain pyrazole compounds exhibiting robust biological activities has spurred interest in this field of inquiry. Heterocyclic compounds incorporating nitrogen and its derivatives have historically served as crucial sources of medicinal compounds. Given that the heterocyclic group constitutes a vast reservoir of organic molecules, its significance in both theoretical and applied chemistry has grown significantly. Extensive literature indicates that researchers have employed diverse synthetic strategies in recent years to produce substituted pyrazole derivatives with promising biological potential as anti-HIV, anti-inflammatory, antitumor and antimicrobial agents. Inflammation, a multifaceted biological response essential for the body’s defense mechanisms, can also contribute to various pathological conditions when dysregulated. Understanding the underlying molecular mechanisms offers a foundation for targeted interventions against inflammatory disorders. These insights fuel ongoing endeavors to discover effective and innovative anti-inflammatory agents with potential therapeutic applications. This review delves into the synthesis and characterization of various pyrazole derivatives, emphasizing structural modifications influencing their anti-inflammatory efficacy. The insights provided herein are invaluable for the rational design and synthesis of novel anti-inflammatory agents. Furthermore, the review concludes with a discussion on future perspectives, underscoring the imperative for further research to optimize the therapeutic potential of pyrazole derivatives as anti-inflammatory agents.

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Section: Introductionmentioning

confidence: 99%

Path of Pyrazoles from Synthetic Factors to Anti-inflammatory Potential: A Review

Vashisht,

Sethi,

Bansal

et al. 2024

ajc

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“…[15] They are used to synthesize analgesic and anti-inflammatory drugs. [16] Physiochemical studies have shown that heterocyclic derivatives can form HÀ bond with DNA and hence can form biologically active complexes. [17] In fact some of the pyrazole derivatives have been used to mimicpurine bases, involving in DNA and RNA, due to their interesting close structural resemblance.…”

Section: Introductionmentioning

confidence: 99%

“…Amidines derivatives have proven to be valuable synthons for the synthesis of a wide range of biological and pharmaceutical active heterocyclic systems [15] . They are used to synthesize analgesic and anti‐inflammatory drugs [16] . Physiochemical studies have shown that heterocyclic derivatives can form H−bond with DNA and hence can form biologically active complexes [17] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of New N‐Pyrazol‐5‐yl) amidine Derivatives: X‐Ray Structure Hirshfeld Surface, and DFT Analyses together with Antibacterial and Antifungal Activity Studies

2023

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We present in this work, the synthesis and characterization of N‐3‐pyrazolyl amidines derivatives obtained in satisfactory yields via one‐pot reaction. New structures of amidines were confirmed by FTIR, 1H NMR, 13C NMR, 13C NMR Dept spectrum and X ray crystallography of N‐benzyl‐N‐(3‐methyl‐1H‐pyrazol‐5‐yl) propanimidamide. In order to determinate the configuration of this amidine we have characterized it using also HRMS, DSC to determine the fusion points, X‐ray crystallography and Hirshfeld Surface analysis. The grown crystal possesses a dielectric behavior and DFT Calculation which has shown linear correlation between theoretical and experimental Hydrogen bond geometry, bond lengths (A°) and Torsion angles of 1 a. The examination of the spectrum and the SEM diagram of amidine 1a allowed us to determine the size of the particles which is of the order of 1.8 μm. All new amidines were screened for their antibacterial and antifungal activities and their phenotypic analysis was performed using the Phenotype Micro Arrays (PMs) tool to determine cellular responses during their respiration process. Amidines had relatively antibacterial activities with an antifungal behavior proving their interface reaction with several microrganisms. Such finding can be useful in medical and agricultural fields. The considered species belong to human's gut flora and soil phytopathogenesis fungi.

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Tailoring pH-sensitive carboxymethyl tamarind kernel gum-based hydrogel for an efficient delivery of hydrophobic drug indomethacin

Meena,

Singh,

Warkar

2024

International Journal of Biological Macromolecules

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Formulation, evaluation and release studies of Indomethacin Suppositories

Cited by 4 publications

References 0 publications

Path of Pyrazoles from Synthetic Factors to Anti-inflammatory Potential: A Review

Path of Pyrazoles from Synthetic Factors to Anti-inflammatory Potential: A Review

Synthesis and Characterization of New N‐Pyrazol‐5‐yl) amidine Derivatives: X‐Ray Structure Hirshfeld Surface, and DFT Analyses together with Antibacterial and Antifungal Activity Studies

Tailoring pH-sensitive carboxymethyl tamarind kernel gum-based hydrogel for an efficient delivery of hydrophobic drug indomethacin

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