Formulation Effects in the Antioxidant Activity of Extract from the Leaves of Cymbopogon citratus (DC) Stapf

Abstract

Cymbopogon citratus DC (Stapf.) is a perennial grass and it is distributed around the world. It is used as a condiment for food and beverage flavouring in the form of infusions and decoctions of its dried leaves. Our previous studies have shown antioxidant, anti-inflammatory and gastroprotective activities for the infusion and its phenolic fractions. The aim of the present work was to develop oral dosage forms from a Cymbopogon citratus extract to be used as a functional food with antioxidant properties. Initially, an essential oil-free infusion was prepared, lyophilized and characterized by HPLC-PDA. Total phenols were quantified with the Folin–Ciocalteu method and the antioxidant activity was assessed by DPPH assay. Gelatine capsules containing the extract with different excipients, selected after DSC and IR trials, were prepared. A formulation exhibiting better antioxidant behaviour in a gastric environment was attained. These results suggest that the proposed formulation for this extract could be a valuable antioxidant product and, consequently, make an important contribution to “preventing” and minimizing diseases related to oxidative stress conditions.

Exploring the Bioactive Potential of Moroccan Lemongrass (Cymbopogon citratus): Investigations on molecular weight distribution, antioxidant and antimicrobial potentials

“…For example, Tazi et al (2024) demonstrated a significant qualitative and quantitative variation of bioactive molecules from the the extracts of C. citratus among samples growing in Asia, Europe, South America, and Africa. In parallel, current studies showed important quantities of total phenolic compounds and flavonoid contents and antioxidant activity [41,42], which are suggested to increase lemongrass biological activitiesʹ effectiveness.…”

OPTIMASI FORMULA LULUR KRIM DAUN MAREME (Glochidion arborescens Blume.) SEBAGAI ANTIOKSIDAN DENGAN VARIASI TEPUNG JAGUNG DAN TEPUNG BERAS MENGGUNAKAN DESAIN FAKTORIAL

“…Langkah utama untuk memiliki kulit yang sehat yaitu dengan melakukan perawatan pada kulit, salah satunya dengan penggunaan lulur (Fauzi, 2012). Salah satu kerusakan yang diakibatkan oleh radikal bebas yaitu timbulnya masalah penuaan kulit (Azahar et al, 2017;Sousa et al, 2021). Radikal bebas dapat diredam dengan antioksidan, dimana antioksidan ini berperan dalam menstabilkan maupun menonaktifkan kerja dari radikal bebas yang akan menyerang sel dan berakibat menyebabkan kerusakan sel (Carmona-Hernandez et al, 2021;Sadowska-Bartosz & Bartosz, 2014).…”

Evaluation of Ethno-Veterinary Grasses from Suburbs through Microscopic Technique: Insights into Antioxidant Defense System and Phenol

“…Polyphenol antioxidants have defensive effects against various infections, including cardiovascular and neurological diseases, as well as malignancies, and possess antioxidant components in rich sources responsible for medicinal properties [33][34][35]. Moreover, most of the polyphenols known so far, have been shown to be able to scavenge free radicals [36].…”