Formulation development of tazarotene-loaded PLGA nanoparticles for follicular delivery in the treatment of inflammatory skin diseases

Kshirsagar, Sharvari M.; Shrestha, Nisha; Kipping, Thomas; Banga, Ajay K.

doi:10.1016/j.ejpb.2024.114346

European Journal of Pharmaceutics and Biopharmaceutics

2024

DOI: 10.1016/j.ejpb.2024.114346

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Formulation development of tazarotene-loaded PLGA nanoparticles for follicular delivery in the treatment of inflammatory skin diseases

Sharvari M. Kshirsagar,

Nisha Shrestha,

Thomas Kipping

et al.

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Cited by 2 publications

References 39 publications

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Enhancing topical delivery of ISRIB: Optimizing cream formulations with chemical enhancers and pH adjustment

Radmard,

Kumar Srivastava,

Shrestha

et al. 2024

International Journal of Pharmaceutics

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Enhancing topical delivery of ISRIB: Optimizing cream formulations with chemical enhancers and pH adjustment

Radmard,

Kumar Srivastava,

Shrestha

et al. 2024

International Journal of Pharmaceutics

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Recent Applications of PLGA in Drug Delivery Systems

Yang,

Zeng,

Luo

et al. 2024

Polymers

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Poly(lactic-co-glycolic acid) (PLGA) is a widely used biodegradable and biocompatible copolymer in drug delivery systems (DDSs). In this article, we highlight the critical physicochemical properties of PLGA, including its molecular weight, intrinsic viscosity, monomer ratio, blockiness, and end caps, that significantly influence drug release profiles and degradation times. This review also covers the extensive literature on the application of PLGA in delivering small-molecule drugs, proteins, peptides, antibiotics, and antiviral drugs. Furthermore, we discuss the role of PLGA-based DDSs in the treating various diseases, including cancer, neurological disorders, pain, and inflammation. The incorporation of drugs into PLGA nanoparticles and microspheres has been shown to enhance their therapeutic efficacy, reduce toxicity, and improve patient compliance. Overall, PLGA-based DDSs holds great promise for the advancement of the treatment and management of multiple chronic conditions.

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Formulation development of tazarotene-loaded PLGA nanoparticles for follicular delivery in the treatment of inflammatory skin diseases

Cited by 2 publications

References 39 publications

Enhancing topical delivery of ISRIB: Optimizing cream formulations with chemical enhancers and pH adjustment

Enhancing topical delivery of ISRIB: Optimizing cream formulations with chemical enhancers and pH adjustment

Recent Applications of PLGA in Drug Delivery Systems

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