Formulation development of Carvedilol compression coated tablet

Shah, Ritesh; Patel, Sachin; Patel, Hetal; Pandey, Sonia; Shah, Shailesh; Shah, Drashti

doi:10.3109/10837450.2011.598167

Cited by 14 publications

(5 citation statements)

References 17 publications

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“…This might be attributed to the fact that as the coating over the tablet increases, the thickness also gets increased that can affect release of drug from coated tablets in colonic media. It was observed that the diameter of the coated tablets was more compared to the core tablets due to the difference in their die cavities of the tablet punching machine and also due to Eudragit S-100 coating [39]. On the other hand, the percentage friability that was less than 1% indicates that the friability is within the specified limit.…”

Section: Discussionmentioning

confidence: 99%

Design, Development, and Optimization of Polymeric Based-Colonic Drug Delivery System of Naproxen

Sharma

Chawla

Pawar

2013

The Scientific World Journal

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The aim of present investigation deals with the development of time-dependent and pH sensitive press-coated tablets for colon specific drug delivery of naproxen. The core tablets were prepared by wet granulation method then press coated with hydroxypropyl cellulose (HPC) or Eudragit RSPO : RLPO mixture and further coated with Eudragit S-100 by dip immerse method. The in vitro drug release study was conducted in different dissolution media such as pH 1.2, 6.8, and 7.4 with or without rat caecal content to simulate GIT conditions. Surface morphology and cross-sectional view of the tablets were visualized by scanning electron microscopy (SEM). All prepared batches were in compliance with the pharmacopoeial standards. The tablets which are compression coated with HPC followed by Eudragit S-100 coated showed highest in vitro drug release of 98.10% in presence of rat caecal content. The SEM of tablets suggested that the number of pores got increased in pH 7.4 medium followed by dissolution of coating layer. The tablets coat erosion study suggested that the lag time depends upon the coating concentrations of polymers. A time-dependent hydrophilic polymer and pH sensitive polymer based press-coated tablets of naproxen were promising delivery for colon targeting.

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Section: Discussionmentioning

confidence: 99%

Design, Development, and Optimization of Polymeric Based-Colonic Drug Delivery System of Naproxen

Sharma

Chawla

Pawar

2013

The Scientific World Journal

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“…The same effect of Eudragit S-100 was reported in previous literature. [27] The hardness was found to be in acceptable range. The friability of all tablets in formulation was in acceptable range of less than 1%, ranging from 0.33% ±0.01% to 0.43% ±0.03%.…”

Section: Resultsmentioning

confidence: 99%

Formulation and in vitro evaluation of Eudragit S-100 coated naproxen matrix tablets for colon-targeted drug delivery system

Rohit

Chawla

Sharma

et al. 2013

J Adv Pharm Tech Res

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The purpose of the present investigation was to prepare matrix tablets of naproxen using a hydrophobic polymer, i.e., Eudragit RLPO, RSPO, and combination of both, by wet granulation method. The tablets were further coated with different concentrations of Eudragit S-100, a pH-sensitive polymer, by dip immerse method. In vitro drug release studies of tablets were carried out in different dissolution media, i.e., 0.1 N HCl (pH 1.2), phosphate buffers pH 6.8 and 7.4, with or without rat cecal content. The swelling studies of the optimized formulation were carried out. The physicochemical parameters of all the formulations were found to be in compliance with the pharmacopoeial standards. The effect of dissolution medium on the surface of matrix tablet was determined by using Scanning Electron Microscopy technique. The stability studies of all formulations were performed as per ICH guidelines. The results demonstrated that the tablets coated with Eudragit S-100 (2% w/v) showed a sustained release of 94.67% for 24 h, but drug release increased to about 98.60% for 24 h in the presence of rat cecal content while the uncoated tablets released the drug within 5 h. With regard to release kinetics, the data were best fitted with the Higuchi model with non-Fickian drug release kinetics mechanism. The stability studies of tablets showed less degradation during accelerated and room temperature storage conditions for 6 months. The enteric-coated Eudragit S-100 coated matrix tablets of naproxen showed promising site-specific drug delivery in the colon region.

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“…One of these is gellan, a high-molecular-weight polysaccharide, already in use as a gelling agent in biomedical and pharmaceutical science and in industry. This gel has also been in use since 2003 to clean wet paper artworks at the Istituto Centrale per il Restauro e la Conservazione del Patrimonio Archivistico e Librario (ICPAL, Rome, Italy) [25,26]. It is a polysaccharide composed of units of β-glucose, α-rhamnose, and β-glucuronic acid which is capable of forming very transparent, thermo-reversible, viscoelastic and rigid gels that can gradually release the water contained within the polymer network [27].…”

Section: Application Of Hydrogel For Cleaning Papermentioning

confidence: 99%

Combining a hydrogel and an electrochemical biosensor to determine the extent of degradation of paper artworks

et al. 2012

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Paper-based artworks are among the most valuable assets for transmission of knowledge. Historical paper is composed of different polysaccharides (e.g. cellulose), binders, and glues. During aging all of these components undergo several degradation processes, as a result of external and intrinsic causes, and these can compromise the state of conservation of the document. In this work, application of a new biotechnological strategy for paper artefact preservation is reported. By making use of innovative and non-invasive materials, for example appropriate hydrogels, in combination with selective electrochemical biosensors, it is possible to simultaneously verify the degradation condition of the paper artwork and then to efficiently clean it, while monitoring the process of removal of both pollution and degradation products. In this paper, we focus on specific examples in which such techniques have been applied to paper artworks and that illustrate the advantages and potential of this biotechnology compared with the traditional paper-cleaning methods currently in use.

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Formulation development of Carvedilol compression coated tablet

Abstract: Batch F7, containing 10 mg PEO WSR 205 and 5 mg HPMC K4M, showed maximum similarity with theoretical profile and zero order drug release kinetic.

Cited by 14 publications

References 17 publications

Design, Development, and Optimization of Polymeric Based-Colonic Drug Delivery System of Naproxen

Design, Development, and Optimization of Polymeric Based-Colonic Drug Delivery System of Naproxen

Formulation and in vitro evaluation of Eudragit S-100 coated naproxen matrix tablets for colon-targeted drug delivery system

Combining a hydrogel and an electrochemical biosensor to determine the extent of degradation of paper artworks

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