Formulation development of Carbamazepine–Nicotinamide co-crystals complexed with γ-cyclodextrin using supercritical fluid process

Improving the Chemical Stability of Amorphous Solid Dispersion with Cocrystal Technique by Hot Melt Extrusion

“…The two physical mixtures showed slight improvement in dissolution rate compared to pure CBZ due to the hydrophilic properties of NIC and PVP/VA which might act as solubilizing agents for CBZ. The same result can be found in the formulation containing CBZ-NIC cocrystal and cyclodextrin (30). For CBZ-PVP/VA solid dispersion, about 67% of CBZ was released within 20 min which clearly demonstrated the improvement of CBZ through solid dispersion technique.…”

Cocrystallization induced by compressed CO2 as antisolvent: Simulation of a batch process for the estimation of nucleation and growth parameters

“…Applications of compressed CO 2 to cocrystal fabrication have been only marginally investigated, using techniques of rapid expansion of supercritical solution [11], supercritical fluid enhanced atomization [12], contacting [13], or antisolvent cocrystallization [14][15][16][17]. As pointed out by Ober and Gupta, a number of unique advantages and opportunities exist when using GAS cocrystallization for pharmaceutical cocrystal engineering: a reduced thermal and mechanical stress on the API compared to grinding processes, a reduced use of organic solvent use compared to traditional solution-based processes in favor of the environmentally benign CO 2 , the facile recycling of the original organic solvent by simple depressurization, and a possible manipulation of the molecular recognition events that occur during cocrystal formation by analogy with the crystal manipulation documented for single species.…”

Challenge of the supercritical antisolvent technique SAS to prepare cocrystal-pure powders of naproxen-nicotinamide

“…Some of them were produced by CO 2 as antisolvent [30][31][32][33][34]. Solution atomization assisted by CO 2 [30,[35][36][37], contacting the two solids into neat CO 2 [30,38] or expanding the {CO 2 + dissolved species} solution [39,40] complete the methods panel.…”