Formulation Development and Stability Studies of Aqueous Metronidazole Benzoate Suspensions Containing Various Suspending Agents

Zietsman, Sharon Lynne; Kilian, Gareth; Worthington, M. S.; Stubbs, C.

doi:10.1080/03639040601011215

Cited by 27 publications

(13 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Dissolution of the suspensions. The dissolution studies were performed following the method described by Zietsman et al, [26] which is based on the United States Pharmacopeia (USP) monograph for metronidazole tablets, with modification of the method to include apparatus II (ERWEKA, DT600, Germany). The dissolution medium was 0.1N HCl (900 mL), and the paddle rotation speed was 100 rpm.…”

Section: Redispersibility Of Suspensionsmentioning

confidence: 99%

Evaluation of carboxymethylated plectranthus edulis starch as a suspending agent in metronidazole benzoate suspension formulations

Brhane

2020

PLoS ONE

View full text Add to dashboard Cite

Some excipients are currently available for the formulation of pharmaceutical suspensions. The objective of this study is to develop cheap and effective starch-based excipient that can be used as an effective alternative for the formulation of pharmaceutical suspensions. Carboxymethylated Plectranthus edulis, Vatke (P. edulis) [fam., Lamiaceae], starch was evaluated as a suspending agent in metronidazole benzoate suspensions in comparison with sodium carboxymethyl cellulose (NaCMC) at a concentration range of 1-4% (w/v). The resulting suspensions were evaluated for their sedimentation volume (%), degree of flocculation, rheology, redispersibility, and dissolution rate. Stability studies were performed for 3 months. The apparent viscosities of the formulations prepared with carboxymethylated P. edulis starch at reaction condition E (CMPS-E) was significantly lower than that of NaCMC (p < 0.05). The flowability of the suspensions, at all concentration levels of the suspending agents, were in the order of CMPS-E > NaCMC. AT 1% concentrations, carboxymethylated P. edulis starch (76 ± 1.5%) provided significantly higher (p < 0.05) sedimentation volume than NaCMC (40 ± 1.5%). At 3% and 4%, both gave comparable sedimentation volume (100%). Potassium dihydrogen phosphate (KH 2 PO 4) employed as a flocculating agent significantly increased (p < 0.05) the sedimentation volume of the suspensions prepared with carboxymethylated P.edulis starch and NaCMC. The redispersibilities of CMPS-E were better than those of NaCMC. All suspensions showed a release of greater than 85% of drug within 1 h. The results of stability studies showed that all suspension formulations were stable. From the foregoing, it can be concluded that carboxymethylated P. edulis starch could be used as an alternative suspending agent.

show abstract

Section: Redispersibility Of Suspensionsmentioning

confidence: 99%

Evaluation of carboxymethylated plectranthus edulis starch as a suspending agent in metronidazole benzoate suspension formulations

Brhane

2020

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Hydrogels formed from MCC/Na-CMC are commonly used in formulations of orally taken products and nasally dosed products (Sharpe et al, 2003;Zietsman et al, 2007). This type of hydrogel gives the required rheological characteristics because it forms a thixotropic system at a low loading, in aqueous media.…”

Section: Introductionmentioning

confidence: 99%

Characterisation of the interactive properties of microcrystalline cellulose–carboxymethyl cellulose hydrogels

Zhao

Kapur

Carlin

et al. 2011

International Journal of Pharmaceutics

View full text Add to dashboard Cite

“…For these drugs, they suggest that dissolution studies must be initiated in a physiologically representative medium to determine an appropriate in vitro-in vivo relationship. On the contrary, some researchers studied generic suspensions of benzoyl metronidazole [15] and metronidazole benzoate [16]. Although both groups used 900 ml of 0.1 N hydrochloric acids as dissolution medium, one group used a USP paddle apparatus at 75 rpm and the other used a USP basket apparatus at 100 rpm.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Release Studies of Carbamazepine Tablets and Benzoyl Metronidazole Suspensions Using the Flow-Through Cell Apparatus and Simulated Gastrointestinal Fluids

2017

View full text Add to dashboard Cite

Objective: To characterize the in vitro release of carbamazepine tablets and benzoyl metronidazole suspensions using the flow-through cell apparatus and simulated gastrointestinal fluids.Methods: Tegretol ® tablets, Flagyl ® suspension, and generic formulations of each were tested. Release studies were performed using an automated flow-through cell apparatus. Simulated gastric fluid (with and without pepsin) and simulated intestinal fluid (without pancreatin) at 16 ml/min and fasted state simulated intestinal fluid at 8 ml/min, all at 37.0±0.5 °C, were used as dissolution media. The quantity of dissolved carbamazepine and benzoyl metronidazole was determined at 5-min intervals until 60 min at 285 and 278 nm, respectively. Percentage dissolved at 60 min, mean dissolution time, dissolution efficiency values, and t10%, t25%, t50% and t63.2% were calculated. Mean values for all parameters were compared between the reference and generic formulations using Studentʼs t-test. Dissolution data were fitted to different kinetic models.Results: Simulated gastric fluid without pepsin showed no discriminative capability for carbamazepine tablets. Significant differences were observed between the reference and generic formulations for almost all parameters (*P<0.05). In some cases, the logistic model best described the in vitro release of both drugs. Conclusion:Using an apparatus and media that best simulates the gastrointestinal environment, we identified differences in the rate and extent of dissolution of both drugs that could help to optimise the design of interchangeable formulations. Based on the physicochemical characteristics of carbamazepine and benzoyl metronidazole and the conditions in which the formulations were tested, these differences could be of clinical relevance.

show abstract

Formulation Development and Stability Studies of Aqueous Metronidazole Benzoate Suspensions Containing Various Suspending Agents

Cited by 27 publications

References 3 publications

Evaluation of carboxymethylated plectranthus edulis starch as a suspending agent in metronidazole benzoate suspension formulations

Evaluation of carboxymethylated plectranthus edulis starch as a suspending agent in metronidazole benzoate suspension formulations

Characterisation of the interactive properties of microcrystalline cellulose–carboxymethyl cellulose hydrogels

In Vitro Release Studies of Carbamazepine Tablets and Benzoyl Metronidazole Suspensions Using the Flow-Through Cell Apparatus and Simulated Gastrointestinal Fluids

Contact Info

Product

Resources

About