Formulation, Development and Evaluation of Herbal Transdermal Patch for Fracture Healing

Abstract

Peristrophe bicalyculata posses expectorant, analgesic, anti-inflamatory, antipyretic and antibacterial properties and has been traditionally used for the management of pain, sprain, and bone fracture. In this study we have tried to incorporate bioactive components of P. bicalyculata in transdermal patches which were developed by solvent casting method. Formulated patches were further evaluated for thickness, folding endurance, moisture content and moisture reuptake. Formulations showing good folding endurance were selected for estimation of the drug content and in-vitro drug release. The patches showing drug content more than 90% and drug release 85% were selected and fitted for Zero-order kinetics. This study will help in the development of transdermal patch for the treatment of bone fracture.

Formulation and evaluation of transdermal patches of leaf ethanol extract Lantana Camara Linn with ethyl cellulose-poly vinyl pyrolidone polymer variations

“…The patch weights were weighed using an analytical balance, where for every 3 patches, the average weight and standard deviation were determined (7,(11)(12)(13)(14).…”

“…Testing of Folding endurance is carried out with the patch repeatedly in the same position until the patch. The number of folds is considered as the value of resistance to folding (7,(11)(12)(13)(14).…”

“…The patches were weighed and stored in a desiccator for 24 hours containing silica. After 24 hours, the patch was reweighed and the percentage of Loss on drying was determined (7,(11)(12)(13)(14).…”

“…Common problems in herbal medicine are bioavailability, solubility, absorption of active substances, and low stability (6). In the context of developing traditional medicinal preparations, further research is needed in the form of transdermal patches (7) A transdermal patch is a topical preparation in the form of a patch where the drug substance can penetrate the skin tissue and the drug is available systemically. The transdermal patch is one of the local preparations that can deliver drugs to the wound site.…”

“…The manufacture of extract preparations in the form of patches is an innovation in the manufacture of preparations to modify the preparation to increase compliance, safety, and comfort for patients. One of the basic components of a patch is a polymer (7). Polymers play an important role in producing patch preparations with good physical characteristics.…”