Formulation Development and Evaluation of Fast Dissolving Tablets of Torsemide

Abstract

Hypertension is a chronic disease that is characterized by a persistently high blood pressure. It can cause strokes, myocardial infarctions, heart failure, and chronic kidney failure if not treated properly. An effort has been made to develop a fast dissolving tablet containing torsemide, which is used in the treatment of hypertension, in enhancing the onset of action, therapeutic response, patient acceptance, and ease of access. Torsemide fast dissolving tablets (FDTs) were prepared by direct compression method using different ratios of super-disintegrants. The prepared tablets were subjected to both pre and post evaluation parameters including Fourier Transform Infrared spectroscopy (FT-IR), Differential Scanning Calorimetry, Micromeritics properties, Hardness, weight variation, friability, disintegration time, wetting time, water absorption ratio and in-vitro dissolution studies. FTIR studies showed that the drug and excipients are compatible. According to the micromeritics analysis, all formulations had acceptable to good flow ability. Tablet hardness and friability indicated that the prepared formulations were having good mechanical strength. The formulation F27 which was prepared by using of super-disintegrant Crospovidone gave the good results for tablet disintegration, wetting time, and water absorption ratio and in-vitro dissolution.

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“…UV spectroscopy was used to determine the absorbance of filtered liquids. All formulations' dissolution rates were investigated 19 .…”