Formulation Development and evaluation of mucoadhesive tablets for vaginal delivery of metronidazole

Deshkar, Sanjeevani Shekhar; Kapare, Harshad S.; Chore, Shramika; Thakre, Anjali; Mahore, Jayashri G.

doi:10.26452/ijrps.v11ispl4.4535

Cited by 2 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Then granules were dried in a hot air oven [biomedica, AI-7981] at 50 ᵒ C for 10 min. 14 The screening of dried granules was passed through sieve # 16 and the dried granules were mixed with talc and magnesium stearate and compressed into tablets using 12 mm punches. [ Isopropyl alcohol q. s q. s q. s q. s q. s q. s q.s q. s ISSN: 2250-1177 [8] CODEN (USA): JDDTAO…”

Section: Formulation Of Ctz Vaginal Tabletmentioning

confidence: 99%

Vaginal delivery of clotrimazole by mucoadhesion for treatment of candidiasis

Rao¹,

Paul²

2021

J. Drug Delivery Ther.

View full text Add to dashboard Cite

The aim of this study was to prepare mucoadhesive vaginal tablets of clotrimazole for treatment of vaginal candidiasis. A combination of mucoadhesive polymers like HPMC K100M, Sodium CMC, and Eudragit L100 were used in different ratios prepare solid dispersions to enhance its solubility. Tablets were prepared by the wet granulation method. Solid dispersions were evaluated for saturation solubility. All tablet batches were evaluated for weight variation, hardness, friability, drug content, swelling index, in vitro drug release study, ex vivo diffusion and mucoadhesive strength. FTIR spectra showed there was no interaction between the drug and the excipients. HPMC K100 M increased the solubility of clotrimazole in simulated vaginal fluid at pH 4.5. Eudragit L100 was shown to increase the swelling and mucoadhesive strength of the tablet, i.e., 3.03 and 3.29 g. The in vitro and ex vivo release of all 9 batches showed between 61 to 78% release in 8h. Ex vivo diffusion studies using sheep vaginal membrane showed 43 to 59% in 6h in simulated vaginal fluid. The release and flux were nearly comparable to marketed tablet i.e., Candid-V6. The drug release of all batches followed the Korsmeyer-Peppas kinetic model, and the mechanism was found to be non‐Fickian/anomalous. Keywords: Clotrimazole, solid dispersion, HPMC K100M, Eudragit L100, Sodium CMC.

show abstract

Section: Formulation Of Ctz Vaginal Tabletmentioning

confidence: 99%

Vaginal delivery of clotrimazole by mucoadhesion for treatment of candidiasis

Rao¹,

Paul²

2021

J. Drug Delivery Ther.

View full text Add to dashboard Cite

show abstract

Polyelectrolyte-Complex-Based Hydrogel Inserts for Vaginal Delivery of Posaconazole and Probiotics

Deshkar,

Yeole,

Mahore

et al. 2023

Gels

View full text Add to dashboard Cite

Worldwide, 40 to 50% of women suffer from reproductive tract infections. Most of these infections are mixed infections, are recurrent and difficult to treat with antimicrobials or antifungals alone. For symptomatic relief of infections, oral antimicrobial therapy must be combined with topical therapy. The purpose of this work is to optimize and develop a polyelectrolyte complex (PEC) of chitosan/anion for the formulation of posaconazole- and probiotic-loaded vaginal hydrogel inserts with prolonged release and significant mucoadhesion. PECs were prepared using chitosan as cationic and carrageenan, pectin and polycarbophil as anionic polymers via a lyophilization technique. PEC formation was confirmed by scanning electron microscopy, Fourier transform infrared spectroscopy and differential scanning calorimetry, by observing changes in its surface, physical and thermal properties. The probiotic, Lactobacillus casei, was added to the PEC during the lyophilization process and the effect on the probiotic viability was studied. The PECs were further compressed along with posaconazole to form hydrogel inserts and optimized using a 32 full-factorial design. The hydrogel inserts were assessed for swelling behavior, drug release, in vitro mucoadhesion and in vitro antifungal activity. The chitosan–pectin hydrogel insert demonstrated excellent mucoadhesion (1.25 N), sustained drug release (88.2 ± 2.4% in 8 h) and a swelling index of 154.7%. The efficacy of hydrogel inserts was evaluated using in vitro study with a co-culture of Lactobacillus casei and Candida albicans. This study revealed an increase in Lactobacilli casei count and a significant drop in the viable count of Candida albicans (4-log reduction in 24 h), indicating the effectiveness of hydrogel inserts in alleviating the fungal infection. Overall, our study demonstrated the potential of the hydrogel insert for preventing vaginal infection and restoring normal vaginal microbiota.

show abstract

Formulation Development and evaluation of mucoadhesive tablets for vaginal delivery of metronidazole

Cited by 2 publications

References 9 publications

Vaginal delivery of clotrimazole by mucoadhesion for treatment of candidiasis

Vaginal delivery of clotrimazole by mucoadhesion for treatment of candidiasis

Polyelectrolyte-Complex-Based Hydrogel Inserts for Vaginal Delivery of Posaconazole and Probiotics

Contact Info

Product

Resources

About