Formulation development and characterization of oxcarbazepine microemulsion for intranasal delivery

Tirunagari, Mamatha; Sameen, Jamal; Nandagopal, Anitha

doi:10.23893/1307-2080.aps.05513

Cited by 7 publications

(5 citation statements)

References 28 publications

(22 reference statements)

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“…We were able to find the average microsphere particle size by dividing the total microsphere size by the total number of microspheres. 13 • Zeta potential Measurements of the Zeta potential were taken using the Malvern Zetasizer, a laser Doppler anemometry-based analyzer that can do multiple angle particle electrophoresis analysis (DTS Ver. 4.10, Malvern Instruments, Malvern, UK).…”

Section: Characterization Of Microspheres • Determination Of Encapsul...mentioning

confidence: 99%

Evaluation of Insulin Loaded Microspheres for Oral Delivery

Vishwakarma,

Tare

2023

IJDDT

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Microsphere-based colon-specific medication delivery devices should improve bioactive chemical administration and residence periods. In the first step, insulin microspheres were made using Eudragit RL 100 and L-100 by quasi-emulsion solvent diffusion. Microspheres were made since prior research showed that colon tissue macrophages could take up drug carrier systems with a molecular weight of 956 m or less. The uptake process allows accurate medication delivery to the specified site. Microspheres’ longer residence time than conventional drug delivery methods may allow dosage reduction and therapeutic efficacy. Because microspheres are permeable, they may be compacted and used to make stronger tablets. Thus, the CPDRS1 formulation performs well, enabling insulin delivery via an anti-diabetic microsphere. Drug-polymer ratio affects microsphere size and form. Variations in emulsifying agent amounts affect microsphere sizes and manufacturing yield. Using appropriate polymer and emulsification agent concentrations improves insulin-loaded Eudrajit L microsphere (Eudrajit RL) formulation and manufacturing yield

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Section: Characterization Of Microspheres • Determination Of Encapsul...mentioning

confidence: 99%

Evaluation of Insulin Loaded Microspheres for Oral Delivery

Vishwakarma,

Tare

2023

IJDDT

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“…In-vitro drug permeation study were performed using the Franz diffusion cell apparatus (EMFDC-6, USA) consisting of donor and accepter chamber separated by Wister rat abdominal skin (shaved) as semipermeable membrane [9,10]. The donor chamber added with 1 gm organogel, acceptor chamber filled with skin pH 6.4-phosphate buffer.…”

Section: In-vitro Drug Permeation and Ex-vivo Flux Studiesmentioning

confidence: 99%

Olive Oil Based Organogels for Effective Topical Delivery of Fluconazole: In-vitro Antifungal Study

Ahmed

Fatima

Mohammed

2020

JPRI

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The objective of the study was to formulate olive oil based organogels for the topical application of fluconazole (FLZ), to ensure the efficient delivery of the drug deeper in to the skin layers. Methods: Nine formulations developed by hot-melt method using olive oil, sorbitan monostearate (SMS) and FLZ. Prepared formulations characterized for macro evaluations, pH, spreadibility, viscosity, gel-sol transition, in-vitro diffusion study. Further optimized formulation evaluated for ex-vivo percutaneous permeation, in-vitro antifungal studies and stability studies by similarity index. Results: The results of evaluated parameters ensure the stability and effectiveness of the prepared olive oil based organogels. In-vitro diffusion studied reflects decrease in drug release with increase in surfactant concentration due to increase in viscosity. Moreover, ex-vivo permeation studies revealed that the permeation of FLZ was enhanced for optimized formulations (F6) as compared to the marketed gel formulation. Further, the optimized formulation exhibits the broad zone of inhibition against fungal strains in comparison to control and marketed product during in-vitro antifungal study. Conclusion: The olive oil based organogels formulation shown the enhanced permeation of FLZ from organogel network structure with good antifungal activity as compared to the marketed formulation. Henceforth, the FLZ organogel formulations could be used topically for the effective treatment of fungal infection.

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“…The aliquots were analyzed using UV spectrophotometer. 17 The use of a natural membrane is vital for envisage the potential drug release characteristic. Freshly excised goat nasal mucosa was used, procured from the slaughterhouse.…”

Section: Characterization Of Microemulsionmentioning

confidence: 99%

“…ASNM loaded nanostructured lipid carriers reported for a nose to brain targeted delivery to enhance the therapeutic efficacy of ASNM in the treatment of Schizophrenia. Pharmacodynamic and pharmacokinetic studies showed high brain bioavailability, better therapeutic and safety profile of ASNM loaded nanostructured lipid carriers via intranasal route 17 . Also, microemulsion and mucoadhesive microemulsion of ASNM was reported with the increased retention time of formulation due to polycarbophil, which leads to a significant effect on ASNM diffusion through nasal mucosa 21 .…”

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confidence: 99%

Untitled

2020

IJPSR

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In the present study, we had developed Asenapine maleate (ASNM) loaded microemulsion (ME) to increase the solubility of Asenapine maleate by components of microemulsion including formulation concern, characterization, mucosal diffusion, stability and nasal ciliotoxicity of Asenapine maleate microemulsion (AME). For nasal delivery of Asenapine maleate, a challenge existing in formulation development is the solubilization of poorly water-soluble Asenapine maleate. The intrinsic solubility of Asenapine maleate is about 0.0312 mg/ml. The purpose of this study was to improve the solubility and to enhance the brain uptake of Asenapine maleate through an o/w microemulsion, with suitable intranasal delivery. The optimal microemulsion formulation consisted of Oleic acid, Tween 80: Propylene glycol (PG) (3:1) and water, with a maximum solubility of Asenapine maleate and no ciliotoxicity, was developed and characterized. AME was characterized for % Transmittance, pH, viscosity, globule size, zeta potential, drug content with in-vitro release studies and Exvivo diffusion studies using Standard Franz Diffusion cell. Further, the behavioural studies were assessed in rats by inducing hyperactivity. The optimized microemulsion was found to be stable and transparent with average globule size 94.40 nm, PDI 0.293 and without showing any ciliotoxicity during its histopathological evaluation on goat nasal mucosa. INTRODUCTION: Asenapine maleate (ASNM), (3aRS, 12bRS)-5-Chloro-2-methyl-2, 3, 3a, 12btetrahydro-1H-dibenzo [2, 3, 6, 7] oxepino [4,5-c] pyrrole (2Z)-2-butenedioate (1:1) is an approved atypical antipsychotic drug belonging to chemical class of dibenzo-oxepino pyrroles with combination antagonist activity at dopamine D2 and serotonin 5-HT2A receptors in the limbic system alleviates symptoms of schizophrenia and bipolar I disorder 1, 2 .

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Formulation development and characterization of oxcarbazepine microemulsion for intranasal delivery

Cited by 7 publications

References 28 publications

Evaluation of Insulin Loaded Microspheres for Oral Delivery

Evaluation of Insulin Loaded Microspheres for Oral Delivery

Olive Oil Based Organogels for Effective Topical Delivery of Fluconazole: In-vitro Antifungal Study

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