Formulation, clinical and histopathological assessment of microemulsion based hydrogel for UV protection of skin

Ghorbanzadeh, Maryam; Farhadian, Nafiseh; Golmohammadzadeh, Shiva; Karimi, Mohammad; Ebrahimi, Mahmoud

doi:10.1016/j.colsurfb.2019.04.015

Cited by 31 publications

(14 citation statements)

References 40 publications

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“…Sesame oil is composed of linoleic acid (39-59%), oleic acid (35-54%), palmitic acid (10%) and stearic acid (5%). These values were extracted from our previous study based on GC analysis [21]. Results are shown in Table 2.…”

Section: Mathematical Resultsmentioning

confidence: 99%

Enhanced bactericidal effect of ceftriaxone drug encapsulated in nanostructured lipid carrier against gram-negative Escherichia coli bacteria: drug formulation, optimization, and cell culture study

Ebrahimi

Farhadian

Karimi

et al. 2020

Antimicrob Resist Infect Control

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Background: Ceftriaxone is one of the most common types of antibiotics used to treat most deadly bacterial infections. One way to alleviate the side effects of medication is to reduce drug consumption by changing the ordinary drug forms into nanostructured forms. In this study, a nanostructured lipid carrier (NLC) containing hydrophilic ceftriaxone sodium drug is developed, and its effect on eliminating gram-negative bacteria Escherichia coli death is investigated.Methods: Double emulsion solvent evaporation method is applied to prepare NLC. Mathematical modeling based on the solubility study is performed to select the best materials for NLC preparation. Haftyzer-Van Krevelen and Hoy's models are employed for this purpose. Drug release from optimized NLC is examined under in vitro environment. Then, the efficacy of the optimized sample on eliminating gram-negative bacteria Escherichia coli is investigated. Results: Mathematical modeling reveals that both methods are capable of predicting drug encapsulation efficiency trends by chaining solid and liquid lipids. However, Haftyzer-Van Krevelen's method can precisely predict the particle size trend by changing the surfactant types in water and oily phases of emulsions. The optimal sample has a mean particle size of 86 nm and drug entrapment efficiency of 83%. Also, a controlled drug release in prepared nanostructures over time is observed under in-vitro media. The results regarding the effectiveness of optimized NLC in killing Escherichia coli bacteria suggests that by cutting drug dosage of the nanostructured form in half, an effect comparable to that of free drug can be observed at longer times. Conclusion: Results confirm that NLC structure is an appropriate alternative for the delivery of ceftriaxone drug with a controlled release behavior.

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Section: Mathematical Resultsmentioning

confidence: 99%

Enhanced bactericidal effect of ceftriaxone drug encapsulated in nanostructured lipid carrier against gram-negative Escherichia coli bacteria: drug formulation, optimization, and cell culture study

Ebrahimi

Farhadian

Karimi

et al. 2020

Antimicrob Resist Infect Control

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“…Nanocarriers and the chemical permeation enhancers can effectively promote penetration with convenient application. In recent years, microemulsion has been widely used in transdermal drug administration due to its prominent penetration-promoting effect (5)(6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

“…They can reduce the interfacial tension between the phases, ultimately reducing droplet aggregation and adhesion to achieve excellent formulation stability (12). The microemulsion is easy to prepare at room temperature, and the oil-in-water type microemulsion exerts a strong solubilizing effect on poor water-soluble drugs (9). The microemulsion also has high moisturizing property and high permeability, and after transdermal administration, a drug depot can be formed in the skin to achieve efficient transdermal delivery of the drug (13).…”

Section: Introductionmentioning

confidence: 99%

Transcutol® P/Cremophor® EL/Ethyl Oleate–Formulated Microemulsion Loaded into Hyaluronic Acid–Based Hydrogel for Improved Transdermal Delivery and Biosafety of Ibuprofen

Zhang

Wang

et al. 2019

AAPS PharmSciTech

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In the present study, a novel transdermal delivery system was developed and its advantages were demonstrated. Ibuprofen is a commonly used anti-inflammatory, antipyretic, and analgesic drug; however, because of its short biological half-life, it must be frequently administered orally and is highly irritating to the digestive tract. To prepare a novel transdermal delivery system for ibuprofen, a microemulsion was used as a drug carrier and dispersed in a hyaluronic acid-based hydrogel (ME/Gel) to increase percutaneous drug absorption while avoiding gastrointestinal tract irritation. The prepared microemulsion had a droplet size of ~90 nm, and the microemulsion had good stability in the hydrogel. Rheological tests revealed that the ME/Gel is a pseudoplastic fluid with decreased viscosity and increased shear rate. It displayed a certain viscoelasticity, and the microemulsion distribution displayed minor effects on the rheological characteristics of the hydrogel system. There was no significant difference in the rheology of the ME/Gel at 25°C and 32°C (normal skin surface temperature), which is beneficial for clinical application. Drug transdermal flux was significantly higher than that of the hydrogel and commercial cream groups (p < 0.01). The 24-h cumulative drug permeation amount was 1.42-fold and 2.52-fold higher than that of the hydrogel and cream groups, respectively. By loading into the ME/Gel, the cytotoxicity of the drug to HaCaT cells was reduced. These results indicate that the prepared ME/Gel can effectively improve transdermal ibuprofen delivery and the biosafety of the drug and could therefore have applicability as a drug delivery system.

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“…Hydrogels based on stable microemulsions have strong permeability and a viscosity suitable for topical application, providing longer-term skin contact. 36 In Vivo Animal Models Burn healing process can be studied by in vitro and in vivo tests using animal models. Animal trials are used to investigate wound healing problems, as well as to assess burn pathology, the effects of drugs or biomaterials on burns, the consequences of burn trauma, and the development of new therapeutic agents.…”

Section: Microparticle Polymer and Burn Healing Processmentioning

confidence: 99%

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Formulation, clinical and histopathological assessment of microemulsion based hydrogel for UV protection of skin

Cited by 31 publications

References 40 publications

Enhanced bactericidal effect of ceftriaxone drug encapsulated in nanostructured lipid carrier against gram-negative Escherichia coli bacteria: drug formulation, optimization, and cell culture study

Enhanced bactericidal effect of ceftriaxone drug encapsulated in nanostructured lipid carrier against gram-negative Escherichia coli bacteria: drug formulation, optimization, and cell culture study

Transcutol® P/Cremophor® EL/Ethyl Oleate–Formulated Microemulsion Loaded into Hyaluronic Acid–Based Hydrogel for Improved Transdermal Delivery and Biosafety of Ibuprofen

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