Formulation, Characterization, and Taguchi Design Study of Eplerenone Lipid-Based Solid Dispersions Integrated with Gelucire

Vasam, Mallikarjun; Maddiboyina, Balaji; Talluri, Chandrashekar; Alagarsamy, Shanmugarathinam; Gugulothu, Bhaskar; Roy, Harekrishna

doi:10.1007/s12668-023-01102-4

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…For decades, lipid-based systems have been utilized to enhance qualities of a wide range of medications. 1 , 2 In particular, lipid-based nanoparticles have shown remarkable benefits in pharmaceutical formulations, including excellent biocompatibility, simplicity of fabrication, tissue specificity, avoidance of reticuloendothelial systems, and nontoxicity. 3 Among lipid nanocarriers, solid-lipid nanoparticles (SLNs) have attracted much attention from academia and industry recently due to their fascinating properties.…”

Section: Introductionmentioning

confidence: 99%

Repaglinide–Solid Lipid Nanoparticles in Chitosan Patches for Transdermal Application: Box–Behnken Design, Characterization, and In Vivo Evaluation

Ali,

Namazi,

Elbadawy

et al. 2024

IJN

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Background Repaglinide (REP) is an antidiabetic drug with limited oral bioavailability attributable to its low solubility and considerable first-pass hepatic breakdown. This study aimed to develop a biodegradable chitosan-based system loaded with REP–solid lipid nanoparticles (REP-SLNs) for controlled release and bioavailability enhancement via transdermal delivery. Methods REP-SLNs were fabricated by ultrasonic hot-melt emulsification. A Box–Behnken design (BBD) was employed to explore and optimize the impacts of processing variables (lipid content, surfactant concentration, and sonication amplitude) on particle size (PS), and entrapment efficiency (EE). The optimized REP-SLN formulation was then incorporated within a chitosan solution to develop a transdermal delivery system (REP-SLN-TDDS) and evaluated for physicochemical properties, drug release, and ex vivo permeation profiles. Pharmacokinetic and pharmacodynamic characteristics were assessed using experimental rats. Results The optimized REP-SLNs had a PS of 249±9.8 nm and EE of 78%±2.3%. The developed REP-SLN-TDDS demonstrated acceptable characteristics without significant aggregation of REP-SLNs throughout the casting and drying processes. The REP-SLN-TDDS exhibited a biphasic release pattern, where around 36% of the drug load was released during the first 2 h, then the drug release was sustained at around 80% at 24 h. The computed flux across rat skin for the REP-SLN-TDDS was 2.481±0.22 μg/cm 2 /h in comparison to 0.696±0.07 μg/cm 2 /h for the unprocessed REP, with an enhancement ratio of 3.56. The REP-SLN-TDDS was capable of sustaining greater REP plasma levels over a 24 h period ( p <0.05). The REP-SLN-TDDS also reduced blood glucose levels compared to unprocessed REP and commercial tablets ( p <0.05) in experimental rats. Conclusion Our REP-SLN-TDDS can be considered an efficient therapeutic option for REP administration.

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Section: Introductionmentioning

confidence: 99%

Repaglinide–Solid Lipid Nanoparticles in Chitosan Patches for Transdermal Application: Box–Behnken Design, Characterization, and In Vivo Evaluation

Ali,

Namazi,

Elbadawy

et al. 2024

IJN

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Role of Gold Nanoparticles in Drug Delivery

Raihan,

Wafa,

Nesar

2024

ejtas

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Recent developments in nanotechnology offer a multitude of approaches for investigating and tracking diverse biological and medical processes at the nanoscale. Nanoparticles can deliver medications directly to cancer cells, aiding in the diagnosis and treatment of diseases like cancer. Gold nanoparticles (AuNPs) are incredibly small gold particles, usually fewer than 100 nanometers in size. They are measured in nanometers. AuNPs are one type of nanoparticle that has shown promise as a medication delivery platform. Their outstanding stability, adjustable chemical and physical characteristics, and biocompatibility make them incredibly beneficial for drug delivery applications. The physical and chemical features of AuNPs' natural characteristics were studied. Localized surface plasmon resonance (LSPR), radioactivity, and a high X-ray absorption coefficient are among the physical characteristics of AuNPs that are commonly used in diagnosis and treatment. Compared to many other nanoparticles, AuNPs can create stable chemical interactions with groups that contain S and N. As a result, AuNPs can bind to a broad range of chemical ligands or polymers used for particular purposes. According to recent research, AuNPs can be easily modified to allow the delivery of pharmaceutical drugs directly to the target tissue. This article provides a brief overview of the more effective synthesis method for AuNPs and how they can be utilized as drug carriers to improve precision medicine.

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Formulation, Characterization, and Taguchi Design Study of Eplerenone Lipid-Based Solid Dispersions Integrated with Gelucire

Cited by 2 publications

References 28 publications

Repaglinide–Solid Lipid Nanoparticles in Chitosan Patches for Transdermal Application: Box–Behnken Design, Characterization, and In Vivo Evaluation

Repaglinide–Solid Lipid Nanoparticles in Chitosan Patches for Transdermal Application: Box–Behnken Design, Characterization, and In Vivo Evaluation

Role of Gold Nanoparticles in Drug Delivery

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