Formulation, characterization and pharmacokinetics of Morin hydrate niosomes prepared from various non-ionic surfactants

Novel non-ionic surfactant proniosomes for transdermal delivery of lacidipine: optimization using 23factorial design andin vivoevaluation in rabbits

“…The instrument is a laser-based multiple angle particle electrophoresis analyzer. The instrument measures the electrophoretic mobility and surface charge Waddad et al, 2013). An aliquot of 0.1 ml of the prepared niosomes derived from proniosomal formulation was added to the zeta cell using an automatic pipette.…”

Preparation, in vitro and in vivo evaluation of polymeric nanoparticles based on hyaluronic acid-poly(butyl cyanoacrylate) and D-alpha-tocopheryl polyethylene glycol 1000 succinate for tumor-targeted delivery of morin hydrate

“…7 The use of biocompatible polymer in the treatment of various ailments has widely expanded over the past decade, among which hyaluronic acid (HA), a naturally occurring polyanionic unbranched polysaccharide, has been implicated in several biological functions, such as cell adhesion and motility, cell proliferation and differentiation, wound healing, and even cancer metastasis. 8,9 More importantly, the overexpression of HA-binding receptors, such as CD44 and RHAMM, has been found on the cell surface of several malignant tumors, 10 and data showed that the interaction of hyaluronan with its cell surface receptors is crucial for tumor progression.…”

“…Morin hydrate (3,5,7,2′,4′-pentahydroxyflavone) (MH), a naturally occurring bioflavonoid identified in a number of fruits, vegetables, and herbs of the Moraceae family, is emerging as a potent therapeutic drug for different maladies, including cardiovascular disease, diabetes mellitus, neurodegenerative disease, cancer, and inflammation.…”

“…7 The standard curve was linear and ranged from 1 to 100 µg/mL, with a correlation coefficient (R 2 ) value of 0.9999. The accuracy was determined by three replicate injections of three different concentrations of MH, and a percent accuracy and relative standard deviation of repeatability found to be between 99.31% and 100.67% and less than 2%, respectively.…”

Development and evaluation of sunscreen creams containing morin-encapsulated nanoparticles for enhanced UV radiation protection and antioxidant activity

“…Self-emulsifying drug delivery systems and niosomes containing morin have been reported for oral and intravenous administration; 25,26 but not via topical application. We therefore developed polymeric NP loaded with morin along with commercially available nano ZnO and nano TiO 2 , aiming to improve the penetration of morin into the skin, with minimum spillover into systemic circulation.…”