Formulation Approaches and Strategies for PEGylated Biotherapeutics

Pak, Roger H.; Finn, Rory F.

doi:10.1007/978-1-4614-7978-9_4

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Applications Of Freeze-drying and Case Studies Of Freeze-dri...1

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2022

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“…The covalent chemical conjugation of biomolecules to hydrophilic polymers (PEG) by PEGylation is a widely used technology to provide a slow release of biotherapeutic drugs over time. In PEGylation, the linker-functionalized PEG polymer conjugated with the reactive side chains of proteins or peptides ( Pak and Finn, 2013 ). PEGylated proteins have gained increased interest owing to the decreased immunogenicity, low dose frequency and longer circulation half-life compared to the non-pegylated proteins.…”

Section: Applications Of Freeze-drying and Case Studies Of Freeze-dri...mentioning

confidence: 99%