Formulation and Realization of a Multicompartmental Model for O2-CO2 Coupled Transport in the Microcirculation

Ye, Guo-Fan

doi:10.1007/978-1-4615-1875-4_2

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…The superscript CD means an average over the cross section. All the lumped pammeters in the equations were reported before [3]. Similarly to our cat brain mode1 [2], this human brain model has 3 arteriole compartments, 1 capillary compartment, 3 venule compartments and 1 tissue compartment.…”

Section: Methods Assume That the Microcirculation Is Simulatedmentioning

confidence: 99%

Extension of a multielement compartmental model for O/sub 2/-CO/sub 2/ transport to time-varying applications

Moore²,

Buerk³

et al.

Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Societ

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Section: Methods Assume That the Microcirculation Is Simulatedmentioning

confidence: 99%

Extension of a multielement compartmental model for O/sub 2/-CO/sub 2/ transport to time-varying applications

Moore²,

Buerk³

et al.

Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Societ

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Molecular Fluorescence, Phosphorescence, and Chemiluminescence Spectrometry

1996

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Autoregulatory Vasodilation of Parenchymal Vessels is Impaired during Cerebral Vasospasm

Yundt¹,

Grubb

Diringer³

et al. 1998

J Cereb Blood Flow Metab

173

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Impaired CBF autoregulation during vasospasm after aneurysmal subarachnoid hemorrhage (SAH) could reflect impaired capacity of distal vessels to dilate in response to reduced local perfusion pressure or simply indicate that the perfusion pressure distal to large arteries in spasm is so low that vessels are already maximally dilated. Autoregulatory vasodilation can be detected in vivo as an increase in the parenchymal cerebral blood volume (CBV). Regional CBV, CBF, and oxygen extraction fraction in regions with and without angiographic vasospasm obtained from 29 positron emission tomography studies performed after intracranial aneurysm rupture were compared with data from 19 normal volunteers and five patients with carotid artery occlusion. Regional CBF was reduced compared to normal in regions from SAH patients with and without vasospasm as well as with ipsilateral carotid occlusion (P < .0001). Regional oxygen extraction fraction was higher during vasospasm and distal to carotid occlusion than both normal and SAH without vasospasm (P < .0001). Regional CBV was reduced compared to normal in regions with and without spasm, whereas it was increased ipsilateral to carotid occlusion (P < .0001). These findings of reduced parenchymal CBV during vasospasm under similar conditions of tissue hypoxia that produce increased CBV in patients with carotid occlusion provide evidence that parenchymal vessels distal to arteries with angiographic spasm after SAH do not show normal autoregulatory vasodilation.

show abstract

Formulation and Realization of a Multicompartmental Model for O2-CO2 Coupled Transport in the Microcirculation

Cited by 3 publications

References 10 publications

Extension of a multielement compartmental model for O/sub 2/-CO/sub 2/ transport to time-varying applications

Extension of a multielement compartmental model for O/sub 2/-CO/sub 2/ transport to time-varying applications

Molecular Fluorescence, Phosphorescence, and Chemiluminescence Spectrometry

Autoregulatory Vasodilation of Parenchymal Vessels is Impaired during Cerebral Vasospasm

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