Formulation and physicochemical evaluation of lozenge tablets containing Salvia offi cinalis

Abstract

Pharyngitis or sore thtableoat is an infl ammation of the oropharynx, which is one of the most common complaints seen by emergency physicians. The aim of this study was to extract the Salvia offi cinalis leaves, and to formulate the lozenge tablets in order to investigate a profi table dosage form. Methods: Lozenge tablets were prepared using wet granulation. The tablets also were evaluated for the physicochemical properties such as hardness, friability, weigh uniformity, thickness and disintegration time. Results:The selected formulation tablets containing 2.5% (w/w) gelatin as a binder and 0.1 ml of Salvia offi cinalis extract showed their physicochemical properties in the acceptable limits. Furthermore, palatability and the taste of the tablets were found desirable after testing by human volunteers. Salvia offi cinalis lozenge tablets were studied under accelerated stability conditions, and based on the stability test results it is suggested to package the tablets as single unit dosage form to drug content constancy. Conclusion: The results clearly indicate that the prepared lozenge tablets can be a good alternative for traditional forms of sage.

The formulation of lozenge using black mulberries (Morus nigra L.) leaf extract as an α-glucosidase inhibitor

“…The disintegration time analysis of lozenges was conducted according to USP 30, using a disintegration tester instrument (Erweka ZT6-1-D, Langen, Germany) containing the phosphate buffer medium maintained at pH 6.2 and 37°C ± 0.5°C. [ 15 ]…”

Preparation, characterization, and radiation absorption study of bentonite clay included soft chewable lozenge formulations

“…All the formulations showed good physical appearance. The gelatin used in the molding method as binder enabled the lozenges containing low-dose bentonite to keep their shape due to its gelling feature [25]. Images of bentonite included and blank lozenges are given in Figure 1.…”