Formulation and Pharmacokinetic Evaluation of Ethyl Cellulose/HPMC-Based Oral Expandable Sustained Release Dosage of Losartan Potassium

Formulation and Preparation of Losartan-Potassium-Loaded Controlled-Release Matrices Using Ethocel Grade 10 to Establish a Correlation between In Vitro and In Vivo Results

“…Previously, Dash and Verma developed a losartan potassium polymeric matrix sustained-release tablet to extend the drug release up to a time of 24 h at a determined rate, and the in vitro dissolution profile for batch B4 was designed with a blend of HPMC K4M (67.2 mg), HPMC K200M (90 mg), and Eudragit RSPO (112.5 mg), where the drug release was about 94–98% [ 57 ]. Wani et al evaluated polymers HPMC K4M/ethyl cellulose-based expandable film (an oral sustained-release dosage form) loaded with losartan potassium, appropriate for extended gastric retention time and extended drug release over 12 h, which could be due to the HPMC K4M polymer’s swelling, diffusion, and erosion, along with the ethyl cellulose’s reduced water penetration, which might have caused drug release retardation [ 58 ]. The authors Chithaluru et al used the USP XXII dissolution apparatus for in vitro drug release experiments, indicating that the formulation (losartan potassium with sodium CMC and ethyl cellulose) produced a sustained effect, with 74.19% release, and due to diffusion along with erosion of the drug from the polymers’ swelling [ 24 ].…”

Food-grade polymers: A new vision in the controlled release of bioactive substances

“…The folded films were placed into a gelatin capsule and fully expanded in the dissolution medium, with sustained LP release for 12 h. Pharmacokinetic studies in rabbits showed that the apparent elimination rate constant (ke) decreased, while the mean residence time (MRT) and elimination half-life (t1/2) increased for both LP and LCA. The relative bioavailability (Fr) of the EF system was also higher than that of the commercial formulation Cozaar ® [36].…”