Formulation and Optimization of Mucoadhesive Microspheres of Valsartan by Using Box-Behnken Design

Lal, Chiman; Garg, Rajeev; Gupta, Gagan

doi:10.22159/ijap.2019v11i4.33710

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…The size of the prepared microspheres was measured by the optical microscopy method using a pre-calibrated stage micrometer and surface morphology is by Scanning Electron Microscopy [12]. Particle size was calculated by using an equation.…”

Section: Particle Size Determination and Surface Morphology By Sem An...mentioning

confidence: 99%

Formulation and Evaluation of Modified Pulsatile Capsule for Chronopharmacotherapy of Rheumatoid Arthritic Pain

JYOTHIRMAYI,

BHARATHI,

SEKHARA REDDY

2024

Int J App Pharm

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Objective: The objective of the present study was to design and evaluate pulsincap system for chrono pharmacotherapy of rheumatoid arthritis that combines advantages of both immediate and sustained release technology with the suitable delay of drug release. Methods: Pulsatile drug delivery system based on pulsincap® technology was designed using mucoadhesive microspheres and Tramadol bilayer tablet plugs. The drug-excipient interaction was carried out by FTIR. Hardness, thickness, lag time, and swelling index all play a role in optimizing tablet plugs. The microspheres were examined for parameters such as particle size, surface morphology, encapsulation efficiency, swelling index, % mucoadhesion, and in vitro dissolution. Results: In modified pulsincaps, bilayer tablet plug shows drug release within 40 min and hydrogel plugs shows good swelling index and suitable lag time. In microspheres formulations, MF9 is the most suitable among them as it shows better drug content, particle size, surface morphology, in vitro drug release, and release kinetics. The drug is released right away, followed by the dissolution of the enteric coating at pH 6.8, followed by a suitable delay of 6 hours, and then the maximum amount of drug release is 99.62% at the end of 10th h. Conclusion: The pulsatile delivery system developed with HPMCK4M and tamarindus gum as plugging material showed a satisfactory lag period when compared to Tamarindus gum alone. Drug release can be achieved from treated gelatin capsule and hydrogel plug for a prolonged period by MF9 formulation.

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Section: Particle Size Determination and Surface Morphology By Sem An...mentioning

confidence: 99%

Formulation and Evaluation of Modified Pulsatile Capsule for Chronopharmacotherapy of Rheumatoid Arthritic Pain

JYOTHIRMAYI,

BHARATHI,

SEKHARA REDDY

2024

Int J App Pharm

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“…The gold sputter was used in this test with the high-vacuum evaporator. The given mucoadhesive microspheres sample was scanned and visualized by photomicrographs 20 .…”

Section: Sem Studiesmentioning

confidence: 99%

Untitled

2022

IJPSR

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The Aim and objective of this work were to build up a gastro retentive drug delivery system. Cimetidine is used as a model drug for making mucoadhesive dosage forms. The formulation can be achieved by using the ionic gelation method. The model drug used in this work plan is categorized in antiulcer treatment. The extended-release mucoadhesive microspheres of the drug provide constant plasma concentration with a less frequent administration and also reduce the side effects to some extent. They provide good administration and enhance patient compliance. The present study aims to develop mucoadhesive microspheres of the model drug by using polymers like Sodium alginate and Carbopol 934 as an excellent mucoadhesive agent that can adhere to the gastrointestinal membrane for sustained drug delivery in the stomach. Calcium chloride was also used for making a solvent system. The preformulation study shows no interaction between drugs and excipients. The prepared microspheres of cimetidine particle size between 167.14-218.23μm. The entrapment efficiency of formulations was found to be 70.06-87.67%. In-vitro drug release after 7 h of F6 formulation showed good release was 85.60 %. SEM of prepared microspheres reveals a very smooth surface with a spherical shape. All prepared formulations exhibit good percentage yield and drug release rate. The increased amount of polymer was raised the particle size of microspheres significantly. In-vitro drug release studies were used to indicate a controlled and prolonged release of drug in the stomach and intestine. So we can say the formulation F6was a better candidate of all the developed formulations.

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Past Decade Attempts on Gastro Retentive Microspheres Using Factorial Design: A Comprehensive Literature

Mundarinti¹,

Ahad²

2021

Int j pharm phytopharm res

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The main intention of floating microspheres is to elevate gastro-retentive time, there by drug release and bioavailability. Floating drug delivery systems glide on gastric fluid for an extended time without leaving the stomach and give good accessibility of the drug systemically and good duration of action for the prolonged period of time. Gastro-retentive microspheres are preferred for local action, local absorption, and preventing drug deterioration at the stomach. This article was made by pearly referring to published research papers of both online and offline journals on gastro retentive microspheres made by factorial design. The authors succeeded in collecting the information about the past decade of work done on gastro retentive drug delivery systems using factorial design. The authors from this study conclude that factorial design is an appreciable technique in the optimization of the gastro retentive dosage form in the form off microspheres for the drug delivery for the extended period of time.

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Formulation and Optimization of Mucoadhesive Microspheres of Valsartan by Using Box-Behnken Design

Cited by 3 publications

References 26 publications

Formulation and Evaluation of Modified Pulsatile Capsule for Chronopharmacotherapy of Rheumatoid Arthritic Pain

Formulation and Evaluation of Modified Pulsatile Capsule for Chronopharmacotherapy of Rheumatoid Arthritic Pain

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Past Decade Attempts on Gastro Retentive Microspheres Using Factorial Design: A Comprehensive Literature

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