Abstract:In-Situ buffer formulation contain agents which immediately buffer the internal environment of the body and increases the stability of acid labile drugs inside the body. Here this approach is used for making combination capsule formulation to reduce the side effects of Nonsteroidal antiinflammatory drugs. Pantoprazole is an acid labile drug which is very useful for the prevention and treatment of NSAID related gastric ulcer, so to reduce its side effects this approach was used. In this Indomethacin is used as … Show more
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