Formulation and optimization of desogestrel transdermal contraceptive patch using crystallization studies

Sachdeva, Vishal; Bai, Yun; Kydonieus, Agis F.; Banga, Ajay K.

doi:10.1016/j.ijpharm.2012.12.014

Cited by 28 publications

(17 citation statements)

References 26 publications

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“…Prepared patches were cut into 3.14 cm 2 pieces and weight of each patch was determined by using digital balance. The average weight of each patch and standard deviations were calculated [15,16].…”

Section: Evaluation Of Transdermal Patches 241 Weight Variationmentioning

confidence: 99%

Formulation and Evaluation of Nateglinide Patches for Transdermal Drug Delivery.

Solunke¹,

Chaudhari²

2017

JCPR

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Transdermal drug delivery is an alternative route for systemic drug delivery which minimizes the absorption and increases the bioavailability. Nateglinide is an Anti-Diabetic drug with a shorter half life, low bioavailability up to 72 % undergoes extensive first pass metabolism are required to maintain the therapeutic level it has chosen as transdermal drug delivery system. The present study was to formulate and evaluate transdermal drug delivery system of Nateglinide using polymers such as HPMC & Eudragit RL100 by solvent casting technique. The prepared formulations were evaluated for different physicochemical characteristics like Weight Variation, Folding Endurance, Flatness, pH of patches, % Moisture Content, % Moisture uptake, % Elongation, % Drug Content & % Drug Release. The drug release characteristics of the formulation were studied in-vitro by using semi-permeable membrane. The in-vitro drug release plot has shown that the drug release followed zero order kinetics & Higuchi model, which was evidenced from the regression values. Based on the drug release and physicochemical values obtained from the formulation F 7 is considered as an optimized formulation which shows higher percentage of drug release (96.27±0.68 % at 14 hour) with diffusion mediated mechanism. Korsmeyer-Peppas exponential plots shows fairly linear & it is well supported by their regression coefficients values & slope value (n) were >1 which suggest that drug was released by Super Case-II transport.

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Section: Evaluation Of Transdermal Patches 241 Weight Variationmentioning

confidence: 99%

Formulation and Evaluation of Nateglinide Patches for Transdermal Drug Delivery.

Solunke¹,

Chaudhari²

2017

JCPR

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“…Patches are commercially available for a constant delivery of various substances like ethinyl estradiol (Sachdeva et al 2013), fentanyl (Lehmann and Zech 1992), lignocaine (Kwon et al 2012), nicotine (Benowitz et al 1991), nitroglycerol (Minghetti et al 2001), rivastigmine (Gauthier et al 2013), rotigotine (Stiasny-Kolster et al 2013), scopolamine (Gil et al 2012), testosterone (James 1995), and others. Such a new preparation is a patch, which represents a sophisticated drug delivery system with the intent to release the active compound in such a manner that the dosing frequency can be reduced in comparison to conventional dosage forms (FDA 2013).…”

Section: Special Formulation Typesmentioning

confidence: 99%

“…Such a new preparation is a patch, which represents a sophisticated drug delivery system with the intent to release the active compound in such a manner that the dosing frequency can be reduced in comparison to conventional dosage forms (FDA 2013). Due to drug storage within the patch, transdermal patches can be classified into three types: (1) drug directly dispersed in adhesive polymer, (2) drug reservoir between a rate con-trolling membrane and a backing membrane, and (3) drug reservoir within the center of a peripheral adhesive ring around the edges (Sachdeva et al 2013). The main advantages of patches are sustained and constant plasma levels and the bypass of the first-pass effect in the liver (Kapil et al 2012).…”

Section: Special Formulation Typesmentioning

confidence: 99%

Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

Dragićević¹,

Maibach²

2015

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“…Slide crystallization studies were performed to identify the appropriate drug concentration in the patch at which the drug does not crystallize during its storage 20 . Different formulations of drug-in-adhesive at various w/w ratios were prepared and smeared on histological slides and were allowed for 24 h at room temperature to evaporate the organic solvents.…”

Section: Slide Crystallization Studiesmentioning

confidence: 99%