Formulation and in vivo pharmacokinetic evaluation of ethyl cellulose-coated sustained release multiple-unit system of tacrolimus

Shin, Taek Hwan; Ho, Myoung Jin; Kim, Dae Jung; Im, Sung Hyun; Kim, Chang‐Hyun; Lee, Sang Kil; Kang, Myung Joo; Choi, Young Wook

doi:10.1016/j.ijbiomac.2017.12.111

Cited by 19 publications

(4 citation statements)

References 21 publications

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“…Ethyl cellulose (EC) is a kind of semi-synthetic membrane forming polymer material, with good thermal stability, biocompatibility and biodegradation in vivo (Shin et al 2018;Lin et al 2021), which has been proved to be an excellent wall material for encapsulation of functional additives including eugenol (Simoes et al 2020), epoxy resin (Wang et al 2020) and curcumin (Pi et al 2018) to produce microspheres with multi-structures (Rogers et al 2012;Muschert et al 2009). Therefore, in this work, ethyl cellulose was used as carrier to prepared resveratrol-loaded EC microspheres by using the foam-transfer method.…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Preparation of resveratrol-loaded ethyl cellulose microspheres via foam- transfer and its application performances

Wang¹,

Gao²,

Pan³

et al. 2022

Preprint

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Resveratrol (Res) has been widely used in personal-care and pharmaceutical products since it has anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. In this work, it was loaded by using biodegradable ethyl cellulose (EC) as the carrier to prepare EC/Res microspheresvia a foam-transfer method. The effects of experimental conditions on the properties of EC/Res microspheres were studied, and then their application performances including the sustained release and the degradation property were investigated. The results showed that resveratrol was loaded to EC microspheres successfully, in which EC/Res microspheres were in highly porous structures. Especially, when the PVA concentration = 2.5 wt%, the stirring rate = 600 rpm, the oil/water (O/W) ratio = 1:2, the polymer concentration = 1:25, the heating rate = 0.33 ℃/min, and the viscosity of ethyl cellulose = 90~110 mpa.s, the yield of EC/Res microspheres was up to 80.70 wt% with an encapsulation ratio of 73.89%; EC/Res microspheres were than produced continuously with an even higher encapsulation rate of resveratrol, which was 90.63% with a yield of 85.58 wt%. The cumulative release of EC/Res microsphere was up to 91.97 wt% in the phosphate buffer solution(PBS) at pH = 5.0 under 45 ℃ for 120 hours. After EC/Res microspheres degraded in PBS (pH = 7.4) for 45 days, their hardness decreased from 12.01 ± 0.56 MPa to 4.02 ± 0.45 MPa. This work provided a practical solution for resveratrol’s application as functional additives in a variety of areas.

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Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Preparation of resveratrol-loaded ethyl cellulose microspheres via foam- transfer and its application performances

Wang¹,

Gao²,

Pan³

et al. 2022

Preprint

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“…Drug release was markedly impeded by the outer EC-based coating layer, displaying about 60% drug release after 8 h, regardless of the acidity of the medium. It was assessed that there were no statistical differences between the obtained pellets and the marketed sustained-release capsules (Advagraf ® ) [29,30]. Shah et al developed a multiunit formulation for the colon-targeted delivery of metronidazole using EC and Eudragit ® S 100 as coating polymers to prevent initial drug release in the gastric region (Figure 3).…”

Section: Applicability Of Ec In Pharmaceutical Formulationsmentioning

confidence: 99%

Ethylcellulose–A Pharmaceutical Excipient with Multidirectional Application in Drug Dosage Forms Development

2019

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Polymers constitute the most important group of excipients utilized in modern pharmaceutical technology, playing an essential role in the development of drug dosage forms. Synthetic, semisynthetic, and natural polymeric materials offer opportunities to overcome different formulative challenges and to design novel dosage forms for controlled release or for site-specific drug delivery. They are extensively used to design therapeutic systems, modify drug release, or mask unpleasant drug taste. Cellulose derivatives are characterized by different physicochemical properties, such as swellability, viscosity, biodegradability, pH dependency, or mucoadhesion, which determine their use in industry. One cellulose derivative with widespread application is ethylcellulose. Ethylcellulose is used in pharmaceutical technology as a coating agent, flavoring fixative, binder, filler, film-former, drug carrier, or stabilizer. The aim of this article is to provide a broad overview of ethylcellulose utilization for pharmaceutical purposes, with particular emphasis on its multidirectional role in the development of oral and topical drug dosage forms.

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“…While hydroxypropyl cellulose can be dissolved and swell to form a hydrogel in water, ethyl cellulose is water-insoluble [74,75,76]. However, ethyl cellulose can dissolve in an organic solvent to produce good film-forming properties and stability [77,78,79]. Typically, ethyl cellulose is used as a film-coating agent for sustained release in pharmaceutical formulations [80].…”

Section: Formulation Design Of Controlled Drug Release Film-forminmentioning

confidence: 99%

Controlled Release Film Forming Systems in Drug Delivery: The Potential for Efficient Drug Delivery

Tran

2019

Pharmaceutics

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Despite many available approaches for transdermal drug delivery, patient compliance and drug targeting at the desired concentration are still concerns for effective therapies. Precise and efficient film-forming systems provide great potential for controlling drug delivery through the skin with the combined advantages of films and hydrogels. The associated disadvantages of both systems (films and hydrogels) will be overcome in film-forming systems. Different strategies have been designed to control drug release through the skin, including changes to film-forming polymers, plasticizers, additives or even model drugs in formulations. In the current review, we aim to discuss the recent advances in film-forming systems to provide the principles and review the methods of these systems as applied to controlled drug release. Advances in the design of film-forming systems open a new generation of these systems.

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Formulation and in vivo pharmacokinetic evaluation of ethyl cellulose-coated sustained release multiple-unit system of tacrolimus

Cited by 19 publications

References 21 publications

WITHDRAWN: Preparation of resveratrol-loaded ethyl cellulose microspheres via foam- transfer and its application performances

WITHDRAWN: Preparation of resveratrol-loaded ethyl cellulose microspheres via foam- transfer and its application performances

Ethylcellulose–A Pharmaceutical Excipient with Multidirectional Application in Drug Dosage Forms Development

Controlled Release Film Forming Systems in Drug Delivery: The Potential for Efficient Drug Delivery

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