Formulation and In-Vitro Evaluation of Enteric Coated Tablet Incorporating Rabeprazole

Abstract

The objective of the work is to try and assess the applicability and manufacturing possibilities to optimize an enteric coated tablet formulation containing Rabeprazole sodium as the drug aiming at the anti-acidity activity with desired drug release properties. Enteric coated tablet was chosen as dosage form being a cost-effective technology for pharmaceutical industry requiring fewer procedures. Before the implementation of the pharmaceutical technological aims, analysis of critical factors influencing the manufacture was carried out. Reproducible manufacturing processes are required to achieve suitability and tablets uniformity to achieve the uniform properties of tablets, which could influence experimental parameters. Rabeprazole in core content of tablet is blended with HPMC (different grades), xanthan gum, PVPK30, mannitol, crosspovidone, Sodium starch glycolate, Colloidal silicon dioxide to formulate the product. Prepared formulation was tested for weight and content uniformity, physical characteristics, in vitro dissolution behaviour, acid resistance and accelerated stability studies. All studies performed resulted and revealed for assurance of such enteric coated tablet formulation for drug Rabeprazole with optimum characteristics, concluding it as a promising approach to enhance drug release characteristics.
 Keywords: Rabeprazole, HPMC, enteric coated tablets, In Vitro evaluation.

Formulation of Dosage Forms with Proton Pump Inhibitors: State of the Art, Challenges and Future Perspectives

“…As in the case of pellets, the literature provides examples of the manufacturing of an intermediate layer, which separates the enteric coat from the core with the therapeutic substance. HPMC or polyvinyl alcohol dispersions are used for this purpose [ 253 , 254 , 255 , 256 , 257 , 258 , 259 , 260 , 261 ]. The intermediate layer is intended to protect the therapeutic substance sensitive to acidic groups of enteral polymers [ 256 ].…”