Formulation and in vitro evaluation of carbopol 934-based modified clotrimazole gel for topical application

Ubaid, Muhammad; Ilyas, Sadaf; Mir, Sadullah; Khan, Abida Kalsoom; Rashid, Rehana; Khan, Muhammad Zia Ullah; Kanwal, Zainab Gul; Nawaz, Ahmad; Shah, Anoop; Murtaza, Ghulam

doi:10.1590/0001-3765201620160162

Cited by 43 publications

(23 citation statements)

References 21 publications

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“…All developed gel formulations were allowed to set in a suitable container and tested for homogeneity by visual inspection and gel appearance was reported. 18,19 Drug content 100.0 mg of gel sample was dissolved in 100.0 ml Phosphate buffer pH 5.5 and shaken the gel solution for two hrs on a mechanical shaker to dissolve drug completely. Then the given solution of prepared gel formulation was filtered and determined drug content by spectrophotometrically at 271 nm using a blank solution (phosphate buffer pH 5.5).…”

Section: Homogeneitymentioning

confidence: 99%

Formulation and Evaluation of Antibacterial Topical Gel of Doxycycline Hyclate, Neem Oil and Tea Tree Oil

Borse¹,

Gangude²,

Deore³

2019

IJPER

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Purpose: To formulate novel topical antibacterial gel containing Doxycycline Hyclate, Tea tree oil and Neem oil to evaluate their antibacterial activity. Methods: Formulation excipients were selected using Drug-excipients compatibility study. Prepared gel was subjected to various evaluation parameters like pH, viscosity, spreadability, homogeneity, drug content uniformity, in-vitro drug diffusion and antibacterial activity. Results: Prepared topical gel of doxycycline Hyclate was shown pH range 5.3±0.010 to 6.7±0.015, viscosity range 386±28.70 to 680±50.40 cp, spreadability range 18.14±0.98 to 28.13±2.18 g.cm/s and homogeneous. Prepared gel was shown uniformity in drug content which ranges from 94.41±0.61 to 97.44±0.69%, zone of inhibition ranges 13.66±1.69 to 32.00±1.63 mm for Staphylococcus aureus, 04.00±1.63 to 12.33±0.94 mm for Pseudomonas aeruginosa and 11.66±0.94 to 33.33±1.24 mm for Propionibacterium acne. Prepared gel formulations were shown the negligible amount of drug diffusion, not more than 3.22±0.04% was shown the non-fickian type of diffusion through the egg membrane. Conclusion: Formulation F8 was shown better antibacterial activity as compared to its other formulations. As the concentration of neem oil and tea tree oil was increased from 0.5 to 3% and 0.5 to 2% respectively in the gel, antibacterial activity was synergistically improved against Staphylococcus aureous, Pseudomonas aeruginosa and Propionibacterium acne. The prepared gel formulation was found useful for topical application due to its negligible diffusion, good spreadability, neutral pH, low viscosity and no irritation on human skin.

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Section: Homogeneitymentioning

confidence: 99%

Formulation and Evaluation of Antibacterial Topical Gel of Doxycycline Hyclate, Neem Oil and Tea Tree Oil

Borse¹,

Gangude²,

Deore³

2019

IJPER

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“…To check this parameter, all gel formulation was taken in suitable container and allowed to settle. The homogeneity was tested by visual inspection (Nawaz A et al, 2013, Ubaid M et al, 2016.…”

Section: Homogeneitymentioning

confidence: 99%

Formulation and Evaluation of Antifungal Topical Gel of C. Tora Seed Extract

Pandey¹,

Mishra²,

Vishwakarma³

2020

IJAR

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Purpose: To formulate novel topical antifungal gel containing seed extract of c.tora. and to evaluate their antifungal potential. Method: the gel was formulated by a cold mechanical method. Prepared gel was subjected to various evaluation parameters like ph, viscosity, spread ability, homogeneity and antifungal activity. Results: Prepared topical gel of extract was pH range of 6.25±0.05 to 6.45±0.15, viscosity range 386±27.90 to 680±45.50cp, spread ability 40±2.5 to 38±2 mm and homogenous. Prepared topical gel was shown zone of inhibition ranges from 13.5±0.5 to 23.5±0.5 mm for candida albicans. Conclusion: Formulation F6 was shown better antifungal activity as compared to its other formulations. The prepared gel formulation was found useful for topical application due to its neutral pH, good spread ability, low viscosity and no irritation on human skin.

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“…To perform ex vivo permeation study [21,22] of formulation showing better release (formulation F4) and marketed formulation (phytoral), franz diffusion cell was chosen. The selected franz diffusion cell was having effective diffusion area of 3.14 cm 2 and cell volume of 15 ml.…”

Section: Ex Vivo Permeation Studymentioning

confidence: 99%

“…"Cup plate method" [9,22] was opted to determine the antifungal activity of optimized formulation F4, in comparison with normal marketed ketoconazole gel (phytoral). Fungal strain Aspergillus niger as the test microorganism was used.…”

Section: Antifungal Activitymentioning

confidence: 99%

Formulation of Ketoconazole Loaded Nano Dispersive Gel Using Swollen Micelles Technique and Its in Vitro Characterization

Reza

Goel

Gupta

et al. 2018

Int J Pharm Pharm Sci

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Objective: The objective of the present work was to formulate and characterize nano dispersive gel (NDG) for topical delivery of water-insoluble antifungal agent ketoconazole in order to enhance its solubility, penetration through the skin and antifungal activity.Methods: Nano dispersion of the drug was first prepared by swollen micelles technique (SMT) using tween 80 and chloroform which is then incorporated into the gel using carbopol 934. Ten formulations of ketoconazole loaded NDG was prepared and characterized for different physicochemical parameters like homogeneity, pH, spreadability, extrudability, practical yield, drug content, in vitro drug release, ex vivo permeation study, and biological parameter antifungal activity.Results: The formulated topical preparation exhibit pH in the range of 6.5 to 7.4, and unveiled excellent homogeneity, spreadability and extrudability. Out of 10 formulations, formulation F4 showed maximum drug content of 95.56±1.13% and practical yield of 97.23±0.51%. The in vitro drug release studies were performed using pH 7.4 phosphate buffer. Formulation F4 showed best in vitro drug release 96.52±0.52% at the end of 24 h of study. Ex vivo permeation study of formulation F4 carried out using franz diffusion cell, also manifested good permeation and flux of drug across the chicken skin. Antifungal activity test of formulation F4 was carried out by the cup plate method using Aspergillus niger strain against marketed ketoconazole unveiled higher antifungal activity than marketed one.Conclusion: The study confirmed formulation F4 to be an optimized and promising formulation for the effective treatment of topical fungal infections with enhanced solubility and penetration through the skin.

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Formulation and in vitro evaluation of carbopol 934-based modified clotrimazole gel for topical application

Cited by 43 publications

References 21 publications

Formulation and Evaluation of Antibacterial Topical Gel of Doxycycline Hyclate, Neem Oil and Tea Tree Oil

Formulation and Evaluation of Antibacterial Topical Gel of Doxycycline Hyclate, Neem Oil and Tea Tree Oil

Formulation and Evaluation of Antifungal Topical Gel of C. Tora Seed Extract

Formulation of Ketoconazole Loaded Nano Dispersive Gel Using Swollen Micelles Technique and Its in Vitro Characterization

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