Formulation and in Vitro Evaluation of Matrix Tablets of Metoclopramide Hydrochloride

Abstract

Objective: The purpose of present study was to formulate oral sustained release matrix tablet of metoclopramide hydrochloride and to evaluate the effect of varying concentrations of hydrophobic and hydrophilic polymers on drug release. Methods:Drug-excipients compatibility studies were carried out by using Fourier transform infrared spectroscopy (FTIR). The matrix tablets were prepared by direct compression technique using Xanthan gum and ethyl cellulose alone and in combination as release retardant. Dicalcium phosphate was used as diluent. The prepared matrix tablets were evaluated for their physicochemical parameters such as weight variation, hardness, friability, content uniformity and in vitro drug release studies were performed using USP-type II (paddle) dissolution apparatus.Results: Pre and post compression parameters were evaluated and all the parameters were found within the limit. The matrix tablets prepared with xanthan gum and combination of xanthan gum and ethyl cellulose were retarded the drug release upto 12 h. Ethyl cellulose alone could not control the drug release for 12 h. The Formulation with drug to xanthan gum (1:1.5), released 97.62 % of drug in 12 h. The kinetic treatment showed that the release of drug follows zero order kinetics (R 2 Conclusion: Matrix tablet is the simple, efficient and economic method to sustain the release of metoclopramide to prevent extrapyramidal side effects.=0.985). Korsmeyer and Peppas equation values of n were found to be in the range of 0.40-0.56, indicating that the drug release mechanism was diffusion.

Formulation and Optimization of Quercetin Loaded Nanosponges Topical Gel: Ex Vivo, Pharmacodynamic and Pharmacokinetic Studies

“…Drug compatibility study of pure quercetin, ethylcellulose, and nanosponges formulated using quercetin was carried out by potassium bromide pellets by applying pressure of 100 kg to form a pellet [25,26]. They formed pellet was scanned in the region of 4000-600 cm-1 using (FTS300 Spectrophotometer (Glab), Canton, MA).…”

Development and Evaluation of Sustain Release Microparticles of Metoproproprolol Succinate

“…The mechanism of drug release can be described by the phenomenon that involves the disentanglement and erosion of the polymer. The release process involves the penetration of water into dry matrix followed by hydration and swelling of the polymer, and diffusion of the drug dissolved in the matrix [14]. For all the formulations, the contribution of polymer relaxation occurs throughout the entire dissolution time period.…”

Investigation of Critical Material Attributes of Nanocellulose in Tablets

“…Carr's index (CI) Bulk density (ρb) and the tapped density (ρt) of the sample were determined with a bulk/tap density test apparatus (Elecrolab, EDT-1020). CI was calculated as 100 times; the ratio of the difference between the tapped density and bulk density to the tapped density was calculated by utilizing the following equation [18][19][20].…”

“…Hausner's ratio (HR) HR is the ratio of bulked density to the tapped density. HR was calculated according to the following equation [18][19][20].…”

“…Angle of repose (AR) It is defined as the angle between the free surfaces of a pile of powder to a horizontal plane. In the present study, the AR was determined using a fixed cone method [18][19][20]. The sample was carefully poured through the funnel until the apex of the cone, thus formed just touched the tip of the funnel.…”