Formulation and in-Vitro Characterization of Mucoadhesive Patches of Root Extract of Adenium Obesum

Abstract

Patches are punched from a sheet that serves as the intermediate product. Oral mucosal medication delivery alternatives to tablets have been studied, including polymers like cellulose etc. can be used to create mucosal patches. The present research was based on the development and in-vitro characterization of mucoadhesive patches of root extract of Adenium obesum utilizing different polymers. Adenium obesum (fresh roots) was obtained from the Unnao region. Eudragit L-100, Propylene glycol, Tween 80, Methanol, Ethanol and HPMCK 4M & HPMCK 15M were purchased from the local market. The initial stages of processing involve grinding the roots into a coarse powder. The Soxhlet equipment was used to extract the powder and then weigh it. After preformulation study, the Adenium obesum mucoadhesive patches were created using the solvent casting technique. Patches were evaluated for physical appearances, thickness, pH, % drug content, in-vitro drug release, SEM and stability. In results, an excellent % drug release was demonstrated by the buccal patch. In order to estimate stability profile of mucoadhesive patches, it was evaluated for physical appearance. In conclusion, patches i.e., F2, F3 and F6 exhibited a significant estimation parameters like drug content, % drug release etc. The buccal drug of herbal (A. obesum) mucoadhesive patch has shown improved stability. It will ease to provide the long-lasting action by suppressing the symptoms of insomnia, agitations etc. Therefore, it may be produced commercially after its successful clinical trials.