Formulation and In Vitro Assessment of Polymeric pH-Responsive Nanogels of Chitosan for Sustained Delivery of Madecassoside
Muhammad Suhail,
I-Hui Chiu,
Arif Ullah
et al.
Abstract:Madecassoside, a triterpenoid saponin compound mainly
isolated
from the gotu kola herb (Centella asiatica), shows an extensive range of biological activities, including antiapoptotic,
antioxidant, anti-inflammatory, moisturizing, neuroprotective, and
wound healing effects. It has been highly used in the management of
eczema, skin wounds, and other diseases. Due to poor oral bioavailability,
membrane permeability, and intestinal absorption, the clinical application
of the madecassoside is limited. Hence, a drug… Show more
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