Equivalent frame modelling of unreinforced masonry buildings allows for nonlinear analysis with relatively low computational cost. The wall components, particularly piers and spandrels, are usually modelled as prismatic beam elements with rectangular cross section. Nonetheless, in case of effective connection between orthogonal walls, the so-called flange effect should be taken in due consideration, resulting into I-, T-and C-shaped cross sections of piers. Specifically, orthogonal walls partly contribute to the in-plane resistance of longitudinal walls, eventually producing some changes in nonlinear behaviour of masonry walls, failure modes, and seismic capacity features. This problem thus requires more advanced computational strategies to assess the flange effect. In this paper, a numerical investigation aimed at assessing the flange effect is presented. A nonlinear finite element (FE) model was calibrated to reproduce the results of experimental tests on a flanged wall system. The FE model was then used to perform a parametric analysis, highlighting variations in the in-plane resistance of longitudinal walls as a result of collaboration with orthogonal walls.