Formulation and Evaluation of Valsartan Pulsincap Drug Delivery System for Treatment of Hypertension

Patil, Omkar A.; Patil, Indrajeet S.; Bilsakar, Vishal V.; Randive, Dheeraj S.; Bhutkar, Mangesh A.; Bhinge, Somnath D.

doi:10.5958/2231-5713.2018.00010.7

Cited by 2 publications

(1 citation statement)

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“…Chronotherapeutic is a treatment method in which in-vivo drug availability is timed to match the circadian rhythms of disease to produce maximum health benefit and to minimize adverse effects (Airemwen et al, 2017). Pulsatile drug delivery technologies are most widely used to target the drug as per the circadian behavior of diseases where the drug is to be released rapidly and completely after a lag time (Patil et al, 2018). The role of chronotherapeutic in hypertension management is based on the observation that blood pressure shows circadian mediated variation throughout the day where it tends to be higher in the early morning hours and lower in the evening hours (Kumar, Suresh, 2018).…”

Section: Introductionmentioning

confidence: 99%

Pulsatile Chronotherapeutic Drug Delivery for Controlling Early Morning Surge in Blood Pressure; Effect of Coating on Eplerenone In-vitro, In-vivo Release and Urinary Na/K Ratio

Marzouk

Darwish

Yassin

et al. 2022

Braz. J. Pharm. Sci.

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Section: Introductionmentioning

confidence: 99%

Pulsatile Chronotherapeutic Drug Delivery for Controlling Early Morning Surge in Blood Pressure; Effect of Coating on Eplerenone In-vitro, In-vivo Release and Urinary Na/K Ratio

Marzouk

Darwish

Yassin

et al. 2022

Braz. J. Pharm. Sci.

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Role of Chronotherapy in the Management of Hypertension: An Overview

Raj,

Mazumder,

Mishra

et al. 2024

CDTH

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The rise in age-adjusted mortality rates from hypertension and hypertensive diseases over the last several years suggests that hypertension is one of the main risk factors for heart disease. As a result, managing hypertension, both via preventive and therapeutic medicine, involves a heavy socioeconomic burden. This review paper's objective is to summarize information on chronotherapy techniques, which can make it possible for an active component to be distributed predictably and at a pace that may also minimize the patient’s illness symptoms. To incorporate published research and review papers, a comprehensive review of the literature from many sources during the past 25 years was conducted. This paper summarizes the principle and method of the chronotherapy technique. The review also throws light on different approaches that could be used to meet the need for medication for the hypertensive patient according to the circadian cycle. From the study, it was concluded that different formulation approaches are there that can work according to the principle of chronotherapy with improvement in drug bioavailability and patient compliance. To encourage future researchers to include chronotherapy in the creation of additional formulations, this review study intends to shed light on various benefits and methods of chronotherapy.

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Formulation and Evaluation of Valsartan Pulsincap Drug Delivery System for Treatment of Hypertension

Cited by 2 publications

References 0 publications

Pulsatile Chronotherapeutic Drug Delivery for Controlling Early Morning Surge in Blood Pressure; Effect of Coating on Eplerenone In-vitro, In-vivo Release and Urinary Na/K Ratio

Pulsatile Chronotherapeutic Drug Delivery for Controlling Early Morning Surge in Blood Pressure; Effect of Coating on Eplerenone In-vitro, In-vivo Release and Urinary Na/K Ratio

Role of Chronotherapy in the Management of Hypertension: An Overview

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