Formulation and evaluation of transdermal patch of aceclofenac.

Nimesulide is a second generation non-steroidal anti-inflammatory agent, which is widely used in the long term therapy of rheumatoid arthritis, in alleviating pain and inflammation. But its short half-life (only 3-4 hr), so its causes more fluctuation. After oral administration Nimesulide causes to produces heart burn, nausea, loose motions, pruritus, etc. The present study based on the preparation of bioadhesive topical gel of Nimesulide, so as to avoid all gastric side effects. For the preparation of bioadhesive topical gel natural polymer aegel marmelos (plant Bale) was used. Bioadhesive polymers are the agents which increases the contact between the formulation and biological membrane, so as to avoid the fluctuation of formulation and behave as a sustained release formulation. In the present study, prepared bioadhesive topical gel was evaluated with the help of different parameters like drug content, spreadability, extrudability, swelling index study, in-vitro drug diffusion study, in-vitro drug release kinetic study and ex-vivo bioadhesive measurement. On the basis of in-vitro drug diffusion study and ex-vivo bioadhesive measurement property of gel, we have concluded that natural polymer aegel marmelos is the best polymer for the preparation of sustained release bioadhesive topical gel.

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“…c) Higuchi's equation: Q = k 2 √t Where Q is the percent of drug release at time t, and k 2 is the diffusion rate constant [18].…”

Section: B) First -Order Equationmentioning

confidence: 99%

In vitro evaluation of topical gel prepared using natural polymer.

Kumar¹,

Verma²

2010

Int. J. Drug Delivery

102

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“…The enhancer ratio was also estimated using the equation: E SS =J SS (enhancer treated)/J ss (control). All the data, hence, found was expressed as a mean ± standard deviation (SD) [24][25][26].…”

Section: Discussionmentioning

confidence: 99%

Formulation and Evaluation of Transdermal Patch of Indomethacin Containing Patchouli Oil as Natural Penetration Enhancer

Das¹,

Ahmed²

2017

Asian J Pharm Clin Res

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Objective: To develop a transdermal patch of Indomethacin using patchouli oil as a natural enhancer to increase transdermal permeation of the drug from the matrix system across rat epidermis. Materials and Methods:The chemical characterization of patchouli oil was done by gas chromatography-mass spectrometry. Transdermal patches of indomethacin were formulated after studying the drug-excipient compatibility studies by differential scanning calorimetry and Fourier transform infrared spectroscopy (FTIR). The transdermal patches were evaluated for various physiochemical properties. In-vitro transdermal permeation was carried using modified Keshary-Chein diffusion cell across rat epidermis. FTIR studies of rat epidermis were done to understand the mechanism of the permeation enhancing effect of the oil from the matrix patch. Result:The results of physiochemical parameters of the transdermal patch were found satisfactory. The transdermal flux obtained of the different concentration of patchouli oil tend to increase with increasing concentration of the oil and the maximum transdermal flux of 61.92 ± 0.89 µg/cm 2 /hr was obtained with formulation F7 (containing 1% w/v of patchouli oil) which is similar to the flux of the formulation F2 containing standard enhancer dimethyl sulphoxide. The skin irritation test did not show any edema and the FTIR data of rat epidermis indicated that patchouli oil enhances transdermal permeation of indomethacin by partial extraction of lipids in the stratum corneum. Conclusion:Thus, the results showed a potential enhancing effect of patchouli oil on the transdermal permeation of the model drug indomethacin and may be used as natural permeation enhancer in transdermal drug delivery systems.

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“…These are also known as thickening agents which expand the consistency of any dosage form by swelling in the aqueous phase and forming gelly like structure. 43 Incorporation of gelling agent to a system makes it thixotropic. 44 HPMC based Emulgel was found to be superior to Carbopol based Emulgel since it showed better drug release rate .…”

Section: Gelling Agentsmentioning

confidence: 99%

Untitled

2016

IJPSR

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Emulgel systems are currently of attention to the pharmaceutical scientists because of their substantial potential to act as drug delivery vehicle by incorporating a broad range of drug molecules. These are either emulsion of water in oil type or oil in water, which is gelled by mixing it with a gelling agent. Incorporation of emulsion into gel makes it a dual control release system & also increases its stability. Due to lack of insoluble excipients and excess oily bases, it demonstrates better drug release as compared to other topical drug delivery system. Due to nongreasy because of the presence of gel phase which favors good patient compliance. In order to understand the potential of emulgel as delivery vehicles, this review gives an overview of the ideal properties, formation, and characterization of emulgels. The use of emulgel -based systems as drug delivery vehicles is reviewed, with particular emphasis being placed on recent developments and future directions.

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Formulation and evaluation of transdermal patch of aceclofenac.

Cited by 77 publications

References 26 publications

In vitro evaluation of topical gel prepared using natural polymer.

In vitro evaluation of topical gel prepared using natural polymer.

Formulation and Evaluation of Transdermal Patch of Indomethacin Containing Patchouli Oil as Natural Penetration Enhancer

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