Formulation and evaluation of thermoreversible mucoadhesive in-situ gel for intranasal delivery of naratriptan hydrochloride

Shelke, Santosh; Shahi, Sadhana R.; Jalalpure, Sunil; Dhamecha, Dinesh; Shengule, Sushant

doi:10.1016/j.jddst.2015.08.003

Cited by 52 publications

(30 citation statements)

References 28 publications

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“…If the gelation temperature is lower than 32ºC, gelation occurs at room temperature leading to difficulty in manufacturing, handling and administering. If the gelation temperature is higher than 34ºC, the formulation will stay as a liquid at body temperature, resulting in nasal drainage (9) . The gelation temperature was determined by placing 2ml of the refrigerated formula(IG1-IG8) in a 10 ml test tube with a diameter 1.0cm and closed using parafilm.…”

Section: Gelation Temperaturementioning

confidence: 99%

“…The samples were diluted with 10 ml SNF and analyzed spectrophotometrically at 282nm, and the amount of the drug released was determined and the study is repeated in triplicate. Release kinetics was studied for the selected formula by using DD solver software (9,18) .…”

Section: In-vitro Release Study Of St In-situ Nasal Gelmentioning

confidence: 99%

“…A portion of 1ml was withdrawn from the receptor compartment at suitable time intervals and replaced with a similar volume of fresh SNF. The samples were diluted with 10 ml SNF and analyzed spectrophotometrically at 282nm and the amount of the drug released was determined and the release was repeated in triplicate (7,9) .…”

Section: Ex Vivo Permeation Studymentioning

confidence: 99%

“…Permeability coefficient(cm/s) of the drug was calculated by using the equation 2, Permeability coefficient= ( ⁄ ) × × Eq(2) Where (dc/dt) ss(μg mL −1 s −1 ) alteration of concentration under steady-state; A is the permeation area equal (3.14cm 2 ); v (mL) the volume of the receiver section; and CD (μg mL −1 ) is the original donor concentration (9) .…”

Section: Ex Vivo Permeation Studymentioning

confidence: 99%

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Formulation and Evaluation of Sustained Release Sumatriptan Mucoadhesive Intranasal in-Situ Gel

Alkufi¹,

Kassab²

2019

IJPS

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Objective: The purpose of this study to develop and optimize nasal mucoadhesive in situ gel IG of sumatriptan ST (serotonin agonist) to enhance nasal residence time for migraine management. Method: Cold method was used to prepare ST nasal in-situ gel, using thermosensitive polymers (poloxamer 407 and/or poloxamer 188) with a mucoadhesive polymer (hyaluronic acid HA) which were examined for gelation temperature and gelation time, pH, drug content, gel strength, spreadability, mucoadhesive force determination, viscosity, in-vitro drug release, and the selected formula was subjected to ex-vivo permeation study and histological evaluation of the sheep mucosal tissue after application. Results: The results showed that the formula IG7 prepared from poloxamer 407(19%), poloxamer188 (4%) and HA (0.5%) had an optimum gelation temperature (32.66±1.52°C), gel strength (43.66± 1.52 sec), mucoadhesive force (8067.93± 746.45dyne\cm2), in-vitro drug release (95.98%) over 6hr, ex-vivo permeation study release (89.6%) during the 6 h. study with no histological or pathological change in the nasal sheep tissue. Conclusion: The ease of administration via a nasal drop of ST coupled with less frequent administration and prolong drug release, will enhance patient compliance.

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Section: Gelation Temperaturementioning

confidence: 99%

Section: In-vitro Release Study Of St In-situ Nasal Gelmentioning

confidence: 99%

Section: Ex Vivo Permeation Studymentioning

confidence: 99%

Section: Ex Vivo Permeation Studymentioning

confidence: 99%

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Formulation and Evaluation of Sustained Release Sumatriptan Mucoadhesive Intranasal in-Situ Gel

Alkufi¹,

Kassab²

2019

IJPS

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“…It is difficult to obtain a steady state condition due to unavoidable fluctuations in the drug concentration. First pass metabolic effect on the drugs is another major limitation of this route which reduces the bioavailability of several important drugs [27] Moreover, variability is also seen due to the presence of food, physiological parameters of the body, diseased condition etc. In a nutshell, the shortcomings of conventional dosage forms can be summarized a sun favorable bio distribution, low bioavailability, lack of water solubility, poor site specificity, low therapeutic response despite high doses and elevated side effects and toxicity.…”

Section: Conventional Drug Delivery System Used For Hyperlipidemiamentioning

confidence: 99%

Review on Antihyperlipedemia Lipophilic Drugs and Their Novel Formulation Approaches

Khairnar¹,

Shelke²,

Rathod

et al. 2017

Int J Pharm Pharm Sci

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It has been ranked as one of the greatest risk factors contributing to prevalence and severity of coronary heart diseases (CHD). CHD, stroke, atherosclerosis and hyperlipidemia are the primary cause of death. The increased levels of serum total cholesterol and low density lipoprotein (LDL) have been reported as a primary risk factor for cardiovascular disease. Hyperlipidemia is irregularly elevated levels of any or all lipids or lipoproteins in the blood i.e. fatty substances are found in the blood. Many drugs have been reported to inihibit the enzymes responsible for the synthesis of Cholesterol. Wherein, solubility is the key parameter for any active ingredient to maintain the desired therapeutic effects. Since various types of formulations are being currently prepared to enhance its solubility which in turn may improve the bioavailability of the drug? Studies reveal that different methodologies were carried out to overcome the bioavailability issue which is the key limiting factor. The present study focuses on the different types of novel formulation approaches of lipid soluble drug.

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In Vitro , Ex Vivo and In Vivo Methods for Characterization of Bioadhesiveness of Drug Delivery Systems

Djekić

Mihalj

2020

Bioadhesives in Drug Delivery

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Formulation and evaluation of thermoreversible mucoadhesive in-situ gel for intranasal delivery of naratriptan hydrochloride

Cited by 52 publications

References 28 publications

Formulation and Evaluation of Sustained Release Sumatriptan Mucoadhesive Intranasal in-Situ Gel

Formulation and Evaluation of Sustained Release Sumatriptan Mucoadhesive Intranasal in-Situ Gel

Review on Antihyperlipedemia Lipophilic Drugs and Their Novel Formulation Approaches

In Vitro , Ex Vivo and In Vivo Methods for Characterization of Bioadhesiveness of Drug Delivery Systems

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