Formulation and evaluation of thermoresponsive polymeric blend as a vaginal controlled delivery system

Alves, Thaís Francine Ribeiro; Souza, Juliana Ferreira de; Rebelo, Márcia de Araújo; Pontes, Katiusca da Silva; Santos, Carolina Alves dos; Lima, Renata de; Jozala, Ângela Faustino; Grotto, Denise; Severino, Patrícia; Rai, Mahendra; Chaud, Marco V.

doi:10.1007/s10971-018-4662-6

Cited by 11 publications

(6 citation statements)

References 38 publications

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“…By calculating the flow index ( n ) using the data related to the rising curve, it was possible to conclude that all formulations have a thixotropic behavior, where the flow index values were less than 1. These results are in agreement with previous results observed for poloxamer hydrogels reported in the literature …”

Section: Resultssupporting

confidence: 94%

“…These results are in agreement with previous results observed for poloxamer hydrogels reported in the literature. 50 In Vitro Release Assay and Mathematical Modeling. In vitro drug release was studied for BUD-loaded NPs (NP_BUD) and NP_BUD incorporated into P407 hydrogels (P407_BUD and P407_NP_BUD) using the Franz cell setup under sink conditions.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Hydrogels Containing Budesonide-Loaded Nanoparticles to Facilitate Percutaneous Absorption for Atopic Dermatitis Treatment Applications

Campos

Proença

Costa

et al. 2021

ACS Appl. Polym. Mater.

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Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disorder characterized by intense itching and recurrent eczematous lesions. Topical corticosteroids are the firstline treatment to control moderate-to-severe AD; however, prolonged application of corticosteroids is required, which can result in dermal atrophy as a side effect. Drug-delivery systems can provide more effective and targeted therapy strategies. In this study, budesonide (BUD) was encapsulated into chitosan (CS)coated PLGA nanoparticles, which were further incorporated into poloxamer hydrogels to improve the anti-inflammatory activity and decrease adverse effects. The nanoparticles were prepared by the emulsification−solvent evaporation technique, and their physicochemical characteristics were evaluated. Rheological properties of the hydrogels, such as viscosity and sol−gel transition temperature, were evaluated with and without nanoparticles. In vitro release kinetics and ex vivo drug absorption studies were performed using Franz diffusion cells. The nanoparticles showed a mean diameter of 324 ± 4 nm, positive ζ potential (20 mV) due to CS coating, and high encapsulation efficiency (>90%). The nanoparticles did not show cytotoxic effects in primary human fibroblasts and keratinocytes; however, all formulations induced the generation of reactive oxygen species. Both nanoparticles and hydrogels were able to change the release kinetics of BUD when compared to the nonencapsulated compound. Nanoparticles were not able to surmount the stratum corneum of excised human skin, but the nanoencapsulation facilitated the skin absorption of BUD. The hydrogels containing nanoparticles or not showed non-Newtonian and pseudoplastic behavior. The nanoformulations seem to be a good candidate to deliver glucocorticoids in the skin of AD patients.

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Section: Resultssupporting

confidence: 94%

Section: ■ Results and Discussionmentioning

confidence: 99%

Hydrogels Containing Budesonide-Loaded Nanoparticles to Facilitate Percutaneous Absorption for Atopic Dermatitis Treatment Applications

Campos

Proença

Costa

et al. 2021

ACS Appl. Polym. Mater.

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show abstract

“…Instead, the bio-adhesive force increased in the presence of CUR-SD, where the molecular nature of the drug enabled the establishment of hydrogen bonds with the mucin. By evaluating for oxidative stress with HeLa cells, the formulation showed the best antioxidant capacity as the good solubility and stability of CUR-SD made it more bioavailable in protecting the cells from oxidative damage [121]. Table 3 illustrates the polymer used, disease type, cell line or animal model used and outcomes of different thermo-responsive formulations.…”

Section: Thermo-responsive Systemsmentioning

confidence: 99%

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

et al. 2020

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An optimal host–microbiota interaction in the human vagina governs the reproductive health status of a woman. The marked depletion in the beneficial Lactobacillus sp. increases the risk of infection with sexually transmitted pathogens, resulting in gynaecological issues. Vaginal infections that are becoming increasingly prevalent, especially among women of reproductive age, require an effective concentration of antimicrobial drugs at the infectious sites for complete disease eradication. Thus, topical treatment is recommended as it allows direct therapeutic action, reduced drug doses and side effects, and self-insertion. However, the alterations in the physiological conditions of the vagina affect the effectiveness of vaginal drug delivery considerably. Conventional vaginal dosage forms are often linked to low retention time in the vagina and discomfort which significantly reduces patient compliance. The lack of optimal prevention and treatment approaches have contributed to the unacceptably high rate of recurrence for vaginal diseases. To combat these limitations, several novel approaches including nano-systems, mucoadhesive polymeric systems, and stimuli-responsive systems have been developed in recent years. This review discusses and summarises the recent research progress of these novel approaches for vaginal drug delivery against various vaginal diseases. An overview of the concept and challenges of vaginal infections, anatomy and physiology of the vagina, and barriers to vaginal drug delivery are also addressed.

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“…This theory analyses the force required to separate two surfaces after adhesion. 32 Therefore, in this study, the mechanism that best fits to explain the interaction between electrospun materials and the mucin disc is the diffusion theory. According to the images in Figure 2, it was possible to observe that after co-electrospun 1.5% NR with PLDLA, there was an increase in the frequency of fiber diameter in the PLDLA +1.5% NR sample (0.5 μm) compared with the PLDLA sample (0.3 μm).…”

Section: Mucoadhesive Propertiesmentioning

confidence: 97%

Development of co‐electrospun membrane composed poly(l‐co‐d,l‐lactic acid) and natural rubber with potential application in dermal dressing

Pinto,

V. Quevedo,

Komatsu

et al. 2024

J of Applied Polymer Sci

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Wound healing represents a global challenge for the healthcare system, resulting in substantial costs and physical and emotional impacts on individuals. There is an increasing demand for innovative alternatives to treat this condition. The co‐electrospinning technique enables the production of porous membrane composed of natural and synthetic polymers, which exhibit unique functions and adjustable mechanical properties that assist in the tissue healing process. Therefore, the present study aims to investigate the physical–chemical, mechanical, and biological properties of membrane composed of poly(l‐co‐d,l‐lactic acid) (PLDLA) co‐electrospun with different concentrations of natural rubber (NR) (1.5%, 2.0%, and 2.5%). Scanning electron microscopy analysis revealed the porous surface of the membranes. Fourier‐transform infrared spectroscopy confirmed the presence of NR in the material. The low Young's modulus obtained in the mechanical tensile test for the PLDLA membrane co‐electrospun with 1.5% NR indicated its elastic capacity under low tension. The results corroborate with the differential scanning calorimetry, and thermogravimetric analysis, which highlights the compatibility between polymers at this specific proportion, as well as in vitro biocompatibility. The findings underscore the potential of PLDLA and NR co‐electrospun membranes as promising candidates for formulating biomaterials for applications such as dermal dressings.

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Formulation and evaluation of thermoresponsive polymeric blend as a vaginal controlled delivery system

Cited by 11 publications

References 38 publications

Hydrogels Containing Budesonide-Loaded Nanoparticles to Facilitate Percutaneous Absorption for Atopic Dermatitis Treatment Applications

Hydrogels Containing Budesonide-Loaded Nanoparticles to Facilitate Percutaneous Absorption for Atopic Dermatitis Treatment Applications

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

Development of co‐electrospun membrane composed poly(l‐co‐d,l‐lactic acid) and natural rubber with potential application in dermal dressing

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