Formulation and Evaluation of Taste Masked Fast Dissolving Tablet of Prazosin Hydrochloride

Aher, Smita S.; Saudagar, R.B.; Chaudhari, Dhanshri

doi:10.22270/jddt.v8i4.1785

Cited by 3 publications

(4 citation statements)

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“…After placing the tablets, rotate the drum 100 times (25 rpm for 4 min). take out the tablets, tidy them of any loose dust, and weigh them precisely [17] . Friability is calculated using following formula, F=(1-w/wo)100 4.…”

Section: Formulation Of Fast Dissolving Tablets-mentioning

confidence: 99%

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Formulation, Evaluation & Comparative Study of Effects of Super Disintegrants in Herbal Fast Dissolving Tablet of Nyctanthes Arbor Tristis.

2024

IJFMR

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The purpose of this research work was to formulate & evaluate the herbal fast dissolving tablet of Nyctanthes Arbor Tristis. Taxonomically, the plant was authenticated by the Padmashri vikhe patil college of Arts, Science, & Commerce in pravaranagar. Ref.No./PVPC/Bot./2023-24/235. The aimed is to treat inflammation associated with Sciatica. A two independent variables of superdisintegrants are used such as crosspovidone & croscarmellose sodium. Using DOE software, 32 full factorial design was used to examine the combined impact of two formulation variables. TLC was performed to identify the beta sitosterol with RF value of 0.77. to determine the physicochemical interaction between the drug & the excipients, FTIR study was done. FTIR study revealed that there is no interaction of the drug and excipient. In this investigation, the tablets were formulated and assessed via direct compression. The powder mixture were compressed into tablet using single punch tablet machine. All the formulations were evaluated for their characteristic such as weight variation, hardness, thickness, friability, disintegration time(DT), and dissolution rate. It was determined from all evaluation parameter that the F9 batch was the optimized batch. It was found that an optimized batch (F9) has good cumulative drug release in 20 minutes (88.87%), DT of 56 seconds, and hardness of 2.923kg/cm2. The comparative studies are done with the marketed formulation. With the commercial formulation, the optimized batchF9 satisfies all standard specification.

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Section: Formulation Of Fast Dissolving Tablets-mentioning

confidence: 99%

“…Weight variation test-The USP weight variation test is carried out by weighing each of the twenty tablets separately, calculating out their average weights, and then comparing each tablets weight to the average. The weight variation test value is given as percentage [17]. Weight variation = (Iw -Aw)/ Aw*100.…”

Section: Formulation Of Fast Dissolving Tablets-mentioning

confidence: 99%

Formulation, Evaluation & Comparative Study of Effects of Super Disintegrants in Herbal Fast Dissolving Tablet of Nyctanthes Arbor Tristis.

2024

IJFMR

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“…At 287 nm, the absorbance of these solutions was measured. Derived from an equation derived from a standard curve [23].…”

Section: Dissolution Testmentioning

confidence: 99%

Design, Development and Optimization of Mouth Dissolving Tablet of Ambrisentan Using Design Expert Software

et al. 2023

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Objective: The rationale of the current work is to design, develop and optimize of mouth dissolving tablet of ambrisentan to treat hypertension. Methods: Sodium starch glycolate and crospovidone were used as the super disintegrants in the direct compression method to create nine ambrisentan mouth-dissolving tablet formulations. Wetting time, drug content, in vitro disintegration time, dispersion time, and dissolution time were all assessed for the produced formulations. Results: Based on the results obtained, formulation F6 containing 30 mg of crospovidone exhibited good wetting time, dispersion time, disintegration time and drug release. The hardness of formulations AS1 to AS9 was found to be in the range of 2.5 to 3.11 Kg/cm2. The friability of formulations AS1 to AS9 was found to be less than 1%. A water absorption ratio was performed for ensuring the moisture sorption and water uptake properties of super disintegrants. The in vitro drug release of formulation AS6 containing a concentration of Crospovidone 30 mg, shows 91.30% drug release respectively at the end of 12 min. Conclusion: The mouth-dissolving tablets of ambrisentan were successfully designed, developed, and fabricated. It can be reasonably concluded that the AS6 batch of mouth-dissolving tablets of ambrisentan with 30 mg of crospovidone exhibited maximum cumulative drug release in 12 min.

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“…Db= M/ Vb Where, M = Mass of the Powder Vb= Bulk volume of the powder 19,20 Tapped Density (Dt) (gm/ml): It is the ratio of total mass of powder to the tapped volume of powder. It was determined by placing a graduated cylinder, containing a known mass of drug-excipient blend, on mechanical tapping apparatus.…”

Section: Granules Characterization (Pre-compression Evaluation)mentioning

confidence: 99%

Evaluation and Characterization of Sildenafil 50 mg Orodispersible Tablets Using Sublimation Technique

Abbas¹,

Ibrahim

Sakran

et al. 2018

Journal of Advanced Pharmacy Research

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Objective: The aim of this work focused on formulation and evaluation of sildenafil 50 mg orodispersible tablets by sublimation technique. Methods: Active ingredient and excipients mixtures were evaluated for physicochemical changes of the drug utilizing FTIR spectroscopy and DSC thermal analysis. Nineteen proposed formulae N1-N19 were prepared by sublimation technique using menthol as a sublimating agent. Three different types of superdisintegrants (sodium starch glycolate, croscarmellose sodium and plasidone XL) were used in three different ratios (3, 6 and 9 % w/w), percentage of inter-granular and intragranular disintegrant. Hydrophilic filler such as mannitol and hydrophobic filler such as microcrystalline cellulose were used in the ratio (1:1, 2:1 and 4:1 w/w).Elimination of bitterness using sucralose as a potent sweetener. Granulation was achieved by alcoholic solution of PVP K25 as binder at Diosna® high shear mixer. Lubricant (hydrophobic magnesium stearate and hydrophilic sodium stearyl fumarate). Un-lubricated granules were characterized for bulk density, tapped density, true density, particle size distribution, Carr'sindex, Hausner ratio, flow rate and angle of repose. Tablets were firstly compressed on rotary machine then subjected to vacuum oven at 60 ᵒ C for 6 hours. Post compression characterization for tablets after sublimation including content uniformity, average weight, hardness, thickness, In-vitro disintegration, friability, wetting time, assay and dissolution profile of the proposed formulae against the immediate release marketed tablet Viagra ® 50 mg tablet. Results: The formula (N 16) which granulated using 1% PVP k25 with 9% plasidone XL (60% of it is inter-granular while 30% intra-granular), menthol 1%, Microcrystalline cellulose: Mannitol 1:1 and magnesium stearate was the most effective formulation as it showed wetting time of 30.7 seconds, disintegration time of 25 seconds and cumulative % drug release of 92.8 and 95.8 % after 1 and 3 minute respectively. Conclusion: Sildenafil 50 mg ODT successfully was prepared by sublimation technique with better wetting time, disintegration time, assay dissolution profile, hardness and friability.

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Formulation and Evaluation of Taste Masked Fast Dissolving Tablet of Prazosin Hydrochloride

Cited by 3 publications

References 1 publication

Formulation, Evaluation & Comparative Study of Effects of Super Disintegrants in Herbal Fast Dissolving Tablet of Nyctanthes Arbor Tristis.

Formulation, Evaluation & Comparative Study of Effects of Super Disintegrants in Herbal Fast Dissolving Tablet of Nyctanthes Arbor Tristis.

Design, Development and Optimization of Mouth Dissolving Tablet of Ambrisentan Using Design Expert Software

Evaluation and Characterization of Sildenafil 50 mg Orodispersible Tablets Using Sublimation Technique

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