Formulation and Evaluation of Sustained Release Matrix Tablet of Anti-Amoebic Drug by Natural Polymers

Bhattacharjee, Sunirmal; Guha, Nilayan; Dutta, Gouranga; Chakraborty, M.; Jana, Mayukh; Paul, Susanta

doi:10.5958/0974-360x.2017.00356.0

Cited by 5 publications

(1 citation statement)

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“…The results demonstrate that all formulations meet this criterion, with friability values ranging from 0.25% to 0.40%. These low friability percentages suggest that the tablets maintain their structural integrity and do not experience excessive erosion during handling, which is a crucial quality attribute for oral dosage forms (Jain et al, 2008). Drug content uniformity is a critical parameter that ensures consistent and accurate dosing of the active pharmaceutical ingredient (API) in each tablet.…”

Section: Post Compression Parametersmentioning

confidence: 99%

Formulation and Evaluation of Sustained Release Atorvastatin Tablets Using Natural Polymers, with a Focus on Okra Gum

Manyam,

Arumilli,

Pakalapati

et al. 2023

IJPSM

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This research study presents the development and evaluation of sustained-release tablets of Atorvastatin using five distinct natural polymers, namely guar gum, xanthan gum, hibiscus gum, okra gum, and soya bean gum, at different drug-polymer ratios. The formulations underwent rigorous pre-compression and post-compression assessments to ensure their quality and efficacy. The utilization of natural polymers in drug formulations has gained significance due to their cost-effectiveness, biocompatibility, and eco-friendliness. In this study, we investigated the potential of these natural polymers to create sustained-release tablets, a vital need for long-term management of conditions like hypercholesterolemia. Atorvastatin, a BCS class-II drug, was chosen as the model drug for this study, as it plays a crucial role in managing cardiovascular diseases related to high blood pressure. The pre-compression tests ensured that the formulations met pharmacopoeial standards for characteristics such as bulk density, angle of repose, compressibility index, and Hausner's ratio. The post-compression studies confirmed that the tablets exhibited acceptable features, including hardness, friability, and weight variation. In vitro dissolution studies revealed that formulation F8, incorporating okra gum as the rate-retarding polymer, exhibited an impressive 98.5% drug release after 10 hours. This suggest that okra gum holds promise as a natural polymer for designing sustained-release drug formulations. Overall, this study provides valuable insights into the use of natural polymers for the controlled release of drugs, particularly Atorvastatin, and could pave the way for further research in this field.

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Section: Post Compression Parametersmentioning

confidence: 99%

Formulation and Evaluation of Sustained Release Atorvastatin Tablets Using Natural Polymers, with a Focus on Okra Gum

Manyam,

Arumilli,

Pakalapati

et al. 2023

IJPSM

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Development and Evaluation of Polyherbal Formulation for the treatment of Dengue Fever

Pravin¹,

Nanthagopal²,

Ayyappan³

2022

RJPT

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Dengue is endemic in more than 100 countries and it is estimated that annually above 390 million infections occur globally. During the period between 1996-2015, a massive increase of more than 500 percent has been recorded in number of dengue cases reported in India. Dengue is a disease caused by any one of four closely related viruses (DEN-1, DEN-2, DEN-3, or DEN-4). The viruses are transmitted to humans by the bite of an infected mosquito (Aedes aegypti). The Aedes aegypti mosquito is the vector of dengue/dengue hemorrhagic fever. Dengue Hemorrhagic Fever is a more severe form of dengue. There is no specific medication for treatment of a dengue infection. In India mostly herbal products are majorly used for many treatments. The development of polyherbal formulation for Dengue Fever in the form of tablets was performed in this present study. The polyherbal tablets were prepared by using herbals like Andrographis paniculata Nees, Carica papaya Linn and Ocimum sanctum Linn leafs with excipients like Lactose Monohydrate, Microcrystalline Cellulose, Cross Povidone, Colloidal Silicon Dioxide, Methyl Paraben and Magnesium Stearate for the treatment of dengue fever. The plants are collected and plants materials was identified and authenticated taxonomically. The presence of active constituents in herbals was confirmed by preliminary phytochemical screening tests. The preformulation studies were carried out for the powder blends; it was evaluated to determine the bulk density, tapped density and the flow characteristics by angle of repose, carr’s index and hausner’s ratio. The data obtained from these studies indicated that the powder blends have good flow properties. The tablets were prepared with powdered herbals leafs and different ratios of excipients by direct compression. The formulated tablets were evaluated for physical characterization like appearance, weight variation, thickness, hardness, friability, and disintegration. Evaluation studies of all formulations shows that the weight variation, friability and disintegration complies with specification. The disintegration study of formulation F3 was concluded the best formulation among other formulation, which shows the faster disintegration. So, formulation F3 was considered as optimized formulation. Finally, among the three formulations, the formulation F3 showed better results than other formulations in respect of evaluation parameters.

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Effect of Gum Karaya on release pattern of Amoxycillin trihydrate from Encapsulated Matrix-based Formulations

Biswas¹,

Bhattacharya²,

Majee³

2023

RJPT

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Hydrophilic swellable polymers can be well used for the fabrication of matrix formulations. The present investigation aimed to develop controlled release matrix formulations of Amoxicillin trihydrate with different concentration of gum karaya, without changing the other factors. The matrix granules, prepared by wet granulation process were first evaluated for different micrometrics properties like bulk density, tapped density, Hausner’s ratio, Carr’s index. The drug content and swelling behavior were also investigated in granular form. After that the matrix granules were encapsulated in empty gelatin shell. The encapsulated granules of Amoxycillin trihydrate were subjected to dissolution studies. The drug release data were analyzed to interpret the drug release kinetics. The drug release data was fitted in kinetic models of zero order, first order, Higuchi and Korsmeyer-Peppas equation. For the formulations with higher concentration of gum karaya, the cumulative percent of drug released versus time plot exhibits curvilinear nature, which suggests that drug release is not dominated by zero order kinetics. The results showed that drug release is much more acquainted with Korsmeyer–Peppas and Higuchi models. The granules with 10-15% of gum karaya reveal the dominance of the highly swollen layer which controls the drug release from the matrix granules.

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Formulation and Evaluation of Sustained Release Matrix Tablet of Anti-Amoebic Drug by Natural Polymers

Cited by 5 publications

References 0 publications

Formulation and Evaluation of Sustained Release Atorvastatin Tablets Using Natural Polymers, with a Focus on Okra Gum

Formulation and Evaluation of Sustained Release Atorvastatin Tablets Using Natural Polymers, with a Focus on Okra Gum

Development and Evaluation of Polyherbal Formulation for the treatment of Dengue Fever

Effect of Gum Karaya on release pattern of Amoxycillin trihydrate from Encapsulated Matrix-based Formulations

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