Formulation and Evaluation of Sustained Release Matrix Tablets of Metformin Hydrochloride Using pH Dependent and pH Independent Methacrylate Polymers

Wadher, Kamlesh; Kakde, Rajendra; Umekar, Milind J.

doi:10.9734/bjpr/2011/255

Cited by 10 publications

(3 citation statements)

References 23 publications

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“…The release data obtained were treated according to zero-order, first-order, Higuchi and korsmeyer-Peppasequation models. To describe the kinetics of drug release from matrix tablets, release data was analyzed according to Kosmeyer et al's equation [13][14][15] as,…”

Section: Determination Of Release Mechanismmentioning

confidence: 99%

Interpolymer Complex of Chitosan and Eudragit L-100: Preparation, Characterization and Drug Release Behavior

Bute¹,

Gupta

Wadher

et al. 2021

JPRI

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Aims: The aim of the present investigation was to prepare interpolymer complex between Chitosan and Eudragit L100, and to evaluate its performance as a matrix for controlled release of drugs, using Diclofenac sodium as a model. Methodology: Interpolymer complex were prepared by combining different % chitosan solutions with different % Eudragit L100 solutions in different ratios. The formation of interpolyelectrolyte complexes (IPEC) between carbopol and Chitosan was investigated, using turbidimetry and viscosity measurement. The structure of the prepared IPEC was investigated using FTIR spectroscopy and DSC. A Rotary compression press was used to formulate matrix tablets of diclofenac sodium using polymers in physical mixture and IPECs.The amount of Diclofenac Sodium released in the dissolution medium was determined spectrophotometrically at 276 nm. Results: The results of the present investigation confirmed the formation of an interpolyelectrolyte complex between Chitosan and Eudragit L 100. The release of the model drug Diclofenac sodium was significantly controlled from tablets made up of the IPEC as compared with polymers alone and in combination. Release profiles were represented by a mathematical model, which indicates that the prepared system releases drug in a zero-order manner by changing the ratio of the IPEC in the tablets. Conclusion: Controlled release drug delivery systems designed to manipulate the drug release to achieve specific clinical objectives that are unattainable with conventional dosage forms.

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Section: Determination Of Release Mechanismmentioning

confidence: 99%

Interpolymer Complex of Chitosan and Eudragit L-100: Preparation, Characterization and Drug Release Behavior

Bute¹,

Gupta

Wadher

et al. 2021

JPRI

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“…Synthetic polymers include povidone, polyethyleneglycols and polymethacrylates. [11][12][13] The present review article deals with all the important strategies of solid dispersion techniques and their applications in pharmaceutical dosage form development.…”

Section: Introductionmentioning

confidence: 99%

Recent and Relevant Methodology in the Advancement of Solid Dispersion

Talla

Wadher

Umekar

et al. 2021

J. Drug Delivery Ther.

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Most of the promising drugs in development channels are poorly water-soluble drugs which limit formulation approaches, clinical application because of their low dissolution and bioavailability. And the major current challenges of the pharmaceutical industry are apropos strategies that improve the water solubility of drugs. Solid dispersion has been considered one of the major evolutions in overcoming these issues with several successfully marketed products. Though solid dispersion has been outlined as an efficient drug delivery system, the design of specific dosage forms for pharmaceutical therapy is necessary to improve the solubility and bioavailability of poorly water-soluble drugs. Solid dispersion can be prepared by several methods such as solvent evaporation, melting, and supercritical fluid technology. This review intends to provide an updated overview of the recent trends over the past few years in solid dispersion preparation techniques and polymer used. Along with the various pharmaceutical strategies and future visions for the solubilization of poorly water-soluble drugs Keywords: Solid dispersion, Bioavailability, Solubility, Dissolution parameters, Polymeric carrier

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“…Time dependent and pH-independent polymers such as ethyl cellulose (EC), hydroxypropyl cellulose (HPC), EudragitV R RL and EudragitV R RS are often employed to prepare the appropriate sustained-release matrix formulations. In particular, methacrylic resins (EudragitV R ) are commonly used as matrix forming polymers of SRSD, since they exhibit high chemical stability, compactability, and variability in physicochemical characteristics (Wadher et al, 2011). Among methacrylic resins, EudragitV R RS PO is a polymer synthesized from acrylic and methacrylic acid esters, containing low-level quaternary ammonium groups, whereas EudragitV R RL PO contains higher level of quaternary ammonium groups (Pignatello et al, 2002;Pawar & Gautam, 2016).…”

Section: Introductionmentioning

confidence: 99%

Sustained-release solid dispersion of pelubiprofen using the blended mixture of aminoclay and pH independent polymers: preparation and in vitro/in vivo characterization

et al. 2017

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The present study aimed to develop the sustained-release oral dosage form of pelubiprofen (PEL) by using the blended mixture of 3-aminopropyl functionalized-magnesium phyllosilicate (aminoclay) and pH-independent polymers. The sustained-release solid dispersion (SRSD) was prepared by the solvent evaporation method and the optimal composition of SRSD was determined as the weight ratio of drug: EudragitV R RL PO: EudragitV R RS PO of 1:1:2 in the presence of 1% of aminoclay (SRSD(F6)). The dissolution profiles of SRSD(F6) were examined at different pHs and in the simulated intestinal fluids. The drug release from SRSD(F6) was limited at pH 1.2 and gradually increased at pH 6.8, resulting in the best fit to Higuchi equation. The sustained drug release from SRSD(F6) was also maintained in simulated intestinal fluid at fasted-state (FaSSIF) and fed-state (FeSSIF). The structural characteristics of SRSD(F6) were examined by using powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FT-IR), indicating the change of drug crystallinity to an amorphous form. After oral administration in rats, SRSD(F6) exhibited the prolonged drug exposure in plasma. For both PEL and PEL-transOH (active metabolite), once a day dosing of SRSD(F6) achieved oral exposure (AUC) comparable to those from the multiple dosing (3 times a day) of untreated drug. In addition, the in vivo absorption of SRSD(F6) was well-correlated with the in vitro dissolution data, establishing a good level A in vitro/in vivo correlation. These results suggest that SRSD(F6) should be promising for the sustained-release of PEL, thereby reducing the dosing frequency.ARTICLE HISTORY

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Formulation and Evaluation of Sustained Release Matrix Tablets of Metformin Hydrochloride Using pH Dependent and pH Independent Methacrylate Polymers

Cited by 10 publications

References 23 publications

Interpolymer Complex of Chitosan and Eudragit L-100: Preparation, Characterization and Drug Release Behavior

Interpolymer Complex of Chitosan and Eudragit L-100: Preparation, Characterization and Drug Release Behavior

Recent and Relevant Methodology in the Advancement of Solid Dispersion

Sustained-release solid dispersion of pelubiprofen using the blended mixture of aminoclay and pH independent polymers: preparation and in vitro/in vivo characterization

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