Formulation and evaluation of rutin-loaded solid lipid nanoparticles for the treatment of brain tumor

Pandian, Sureshbabu Ram Kumar; Pavadai, Parasuraman; Vellaisamy, Sivakumar; Ravishankar, Vigneshwaran; Palanisamy, Ponnusamy; Sundar, Lakshmi M.; Chandramohan, Vivek; Murugesan, Sankaranarayanan; Panneerselvam, Theivendren; Kunjiappan, Selvaraj

doi:10.1007/s00210-020-02015-9

Cited by 33 publications

(24 citation statements)

References 53 publications

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“…A review of the literature shows that the release kinetics of Ru can vary depending on the drug carrier used in the various nanosystems but that it mostly releases with mixed kinetic mechanisms, similar to our results. In this way, the release pattern of Ru from solid lipid nanoparticles is a good fit to the first-order and Korsmeyer-Peppas models (Pandian et al, 2020), in keeping with results showing Eudragit nanosphere release with Korsmeyer-Peppas and phase II kinetics (Asfour & Mohsen, 2018), and mesoporous silica nanoparticle release through Higuchi and first-order kinetics (Karnopp et al, 2020). Concerning the co-delivery strategy, the release of Ru or Pip with other drugs also can occur via combined kinetic mechanisms.…”

Section: In Vitro Release Kineticssupporting

confidence: 82%

Anti-inflammatory and antioxidant effects of nanoformulations composed of metal-organic frameworks delivering rutin and/or piperine natural agents

et al. 2021

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Plant-derived natural medicines have been extensively studied for anti-inflammatory or antioxidant properties, but challenges to their clinical use include low bioavailability, poor solubility in water, and difficult-to-control release kinetics. Nanomedicine may offer innovative solutions that can enhance the therapeutic activity and control release kinetics of these agents, opening the way to translating them into the clinic. Two agents of particular interest are rutin (Ru), a flavonoid, and piperine (Pip), an alkaloid, which exhibit a range of pharmacological activities that include antioxidant and anti-inflammatory effects. In this work, nanoformulations were developed consisting of two metal-organic frameworks (MOFs) with surface modifications, Ti-MOF and Zr-MOF, each of them loaded with Ru and/or Pip. Both MOFs and nanoformulations were characterized and evaluated in vivo for anti-inflammatory and antioxidant effects. Loadings of $17 wt.% for a single pro-drug and $27 wt.% for dual loading were achieved. The release patterns for Ru and or Pip followed two stages: a zero-order for the first 12-hour stage, and a second stage of stable sustained release. At pH 7.4, the release patterns best fit to zeroorder and Korsmeyer-Peppas kinetic models. The nanoformulations had enhanced anti-inflammatory and antioxidant effects than any of their elements singly, and those with Ru or Pip alone showed stronger effects than those with both agents. Results of assays using a paw edema model, leukocyte migration, and plasma antioxidant capacity were in agreement. Our preliminary findings indicate that nanoformulations with these agents exert better anti-inflammatory and antioxidant effects than the agents in their free form.

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Section: In Vitro Release Kineticssupporting

confidence: 82%

Anti-inflammatory and antioxidant effects of nanoformulations composed of metal-organic frameworks delivering rutin and/or piperine natural agents

et al. 2021

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“…Solid-lipid nanoparticles (SLNs) composed of lipids have excellent physiological acceptability, bio-compatible, biodegradable with minimal human toxicity and can be used as novel pharmaceutical drug delivery systems. SLNs provides many benefits: they protect the drug against enzymatic degradation, controllable drug release, and dismiss the use of toxic organic solvents (Pandian et al, 2020). For the efficient treatment of Chagas disease, many researchers used SLNs, Carneiro et al (2014), for example, developed 5-hydroxy-3-methyl-5-phenylpyrazoline-1-(S-benzyl dithiocarbazate) (H 2 bdtc)-encapsulated SLNs against Chagas disease.…”

Section: Nano-engineered Particles For the Treatment Of Chagas Diseasementioning

confidence: 99%

Nano Based Approach for the Treatment of Neglected Tropical Diseases

Pandian

Panneerselvam

Pavadai

et al. 2021

Front. Nanotechnol.

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Neglected tropical diseases (NTDs) afflict more than one billion peoples in the world’s poorest countries. The World Health Organization (WHO) has recorded seventeen NTDs in its portfolio, mainly caused by bacterial, protozoal, parasitic, and viral infections. Each of the NTDs has its unique challenges on human health such as interventions for control, prevention, diagnosis, and treatment. Research for the development of new drug molecules against NTDs has not been undertaken by pharmaceutical industries due to high investment and low-returns, which results in limited chemotherapeutics in the market. In addition, conventional chemotherapies for the treatment of NTDs are unsatisfactory due to its low efficacy, increased drug resistance, short half-life, potential or harmful fatal toxic side effects, and drug incompetence to reach the site of parasite infection. In this context, active chemotherapies are considered to be re-formulated by overcoming these toxic side effects via a tissue-specific targeted drug delivery system. This review mainly emphasizes the recent developments of nanomaterial-based drug delivery systems for the effective treatment of NTDs especially sleeping sickness, leishmaniasis, chagas disease, soil-transmitted helminthiasis, african trypanosomiasis and dengue. Nanomaterials based drug delivery systems offer enhanced and effective alternative therapy through the re-formulation approach of conventional drugs into site-specific targeted delivery of drugs.

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“…Ligand topology was selected from PRODRG server. The system preparation of all the complexes was as described earlier [18]. Each complex was allowed a simulation time of 50 ns.…”

Section: Molecular Dynamics and Free Energy Calculationmentioning

confidence: 99%

Delivery of Ursolic Acid by Polyhydroxybutyrate Nanoparticles for Cancer Therapy: in silico and in vitro Studies

et al. 2021

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Ursolic acid (UA), a pentacyclic triterpenoid and a phytochemical, is a potent inhibitory agent against proliferation of various tumors. Polyhydroxybutyrate nanoparticles (PHB NPs) are preferred in therapeutics due to their drug-stabilizing property and enhanced biological activity. In this study, PHB NPs were utilized to deliver and enhance the bioavailability of UA against cancer cells (HeLa). Further, molecular docking and dynamic studies were conducted to calculate the binding affinity and stability of UA at the active site of target protein (epidermal growth factor receptor-EGFR). The PHB NPs revealed the average size as 150–200 nm in TEM, which were used in subsequent experiments. The cytoplasmic uptake of nanoparticles was confirmed by florescent microscopy. The encapsulation potential of PHB NPs with UA was assessed by UV–visible spectrophotometer as 54%. Besides, the drug release behavior, cytotoxicity and the regulation of apoptosis were investigated in vitro. The cytotoxicity results revealed that the maximum efficiency of drug delivery was at 96th hour.

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Formulation and evaluation of rutin-loaded solid lipid nanoparticles for the treatment of brain tumor

Cited by 33 publications

References 53 publications

Anti-inflammatory and antioxidant effects of nanoformulations composed of metal-organic frameworks delivering rutin and/or piperine natural agents

Anti-inflammatory and antioxidant effects of nanoformulations composed of metal-organic frameworks delivering rutin and/or piperine natural agents

Nano Based Approach for the Treatment of Neglected Tropical Diseases

Delivery of Ursolic Acid by Polyhydroxybutyrate Nanoparticles for Cancer Therapy: in silico and in vitro Studies

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