Formulation and evaluation of rizatriptan Benzoate mouth disintegrating tablets

Keny, R. V.; Desouza, Chrisma; Lourenco, C. F.

doi:10.4103/0250-474x.62253

Cited by 13 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The blended material was compressed on 8 mm standard concave punch using a mini press tablet punching machine (RIMEK, India). The total weight of formulation was made up to 150 mg [ 14 , 15 ].…”

Section: Methodsmentioning

confidence: 99%

Formulation and Evaluation of New Glimepiride Sublingual Tablets

Al-Madhagi

Albarakani

Alhag

et al. 2017

Journal of Pharmaceutics

View full text Add to dashboard Cite

Oral mucosal delivery of drugs promotes rapid absorption and high bioavailability, with a subsequent immediate onset of pharmacological effect. However, many oral mucosal deliveries are compromised by the possibility of the patient swallowing the active substance before it has been released and absorbed locally into the systemic circulation. The aim of this research was to introduce a new glimepiride formula for sublingual administration and rapid drug absorption that can be used in an emergency. The new sublingual formulation was prepared after five trials to prepare the suitable formulation. Two accepted formulations of the new sublingual product were prepared, but one of them with disintegration time of 1.45 min and searching for preferred formulation, the binder, is changed with Flulac and starch slurry to prepare formula with disintegration time of 21 seconds that supports the aim of research to be used in an emergency. The five formulations were done, after adjusting to the binder as Flulac and aerosil with disintegration time of 21 seconds and accepted hardness as well as the weight variation. The assay of a new product (subglimepiride) is 103% which is a promising result, confirming that the formula succeeded. The new product (subglimepiride) is accepted in most quality control tests and it is ready for marketing.

show abstract

Section: Methodsmentioning

confidence: 99%

Formulation and Evaluation of New Glimepiride Sublingual Tablets

Al-Madhagi

Albarakani

Alhag

et al. 2017

Journal of Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…1 ml of the stock arrangement was additionally weakened to 100 ml. Coming about arrangements were examined in the range of 400 to 200 nm utilizing methanol as a clear with the assistance of a UV-visible spectrophotometer [20]. Normal triplicate readings were taken.…”

Section: Determination Of λMaxmentioning

confidence: 99%

Design, Development and Evaluation of Mouth Dissolving Tablets of Tofacitinib Citrate

RAYKAR

Velraj

2022

Int J App Pharm

View full text Add to dashboard Cite

Objective: This study aims to Formulate Mouth Dissolving Tablets (MDTs) of Tofacitinib Citrate with the increase in bioavailability and patient compliance. Methods: Mouth Dissolving Tablets (MDTs) of Tofacitinib Citrate were developed by full factorial design at 32levelsand prepared by direct compression method using super integrants like sodium starch glycolate, Ludiflash. The tablets were compressed into compacts on a 10 station tablet machine. The bulk drug was characterised by determining, MP, Solubility, pH and FTIR spectra. Results: The weight variation, hardness and diameter, thickness, friability, drug content, wetting time, in vitro disintegration time and in vitro dissolution studies, and stability study, tablet thickness, weight variation and drug content post compression parameters remained consistent and reproducible. All the formulations showed, almost 100 percent of drug release within 75 min. Formulations F1, F2 and F3 were prepared with 5 mg of SSG and 20 mg, 30 mg, and 40 mg Ludiflash which shows % release of drug in the order of F1<F2<F3. Formulations F4, F5 and F6 were prepared with 10 mg of SSG and 20 mg, 30 mg, and 40 mg Ludiflash which shows % release of drug in the order of F4<F5<F6. Formulations F7, F8 and F9 were prepared with 15 mg of SSG and 20 mg, 30 mg, and 40 mg Ludiflash which shows % release of drug in the order of F7<F8<F9. Conclusion: It is concluded that the amount of superdisintegrants decreases disintegration time of tablets, decreases wetting time, increases the cumulative % drug release causes better absorption.

show abstract