Formulation and Evaluation of Polyherbal Antiaging Cream

Yadav, Aman; Mishra, Dinesh Kumar; Paliwal, Pritesh; Farooqui, Nadeem; Gawshinde, Arpit

doi:10.52711/2231-5713.2021.00047

Cited by 6 publications

(1 citation statement)

References 6 publications

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“…2. The viscosity of creams is significant in their application, since relatively low viscosity leads to easy flow off the surface and high viscosity causes problems with spreading [ 26 ]. The viscosity of the formulations were in the order C2 > C1, but both were in the acceptable range and easily flowed off the skin (ANOVA; p < 0.05).…”

Section: Resultsmentioning

confidence: 99%

Formulation, In Vitro Characterization and Antibacterial Activity of Chitosan-Decorated Cream Containing Bacitracin for Topical Delivery

et al. 2022

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(1) Background: Bacitracin is a broad spectrum antibiotic that is used against various microorganisms. Chitosan is a natural polymer that has been widely investigated as an antimicrobial agent for preventing and treating infections owing to its intrinsic antimicrobial properties, as well as its ability to effectively deliver extrinsic antimicrobial compounds to infected areas. Topical drug delivery offers important benefits for improving the therapeutic effect and reducing systemic side effects of administered compounds/drugs. The topical use of chitosan-decorated bacitracin-loaded cream improves the permeation of the drug across the skin and enhances the drug bioavailability by prolonging the residence time of the drug when applied topically, as well as producing synergistic effects and reducing the side effects of the drug. Topical chitosan-decorated cream can be a promising approach to administer the drug more efficiently and enhance the efficacy of treatment in wound healing and antibacterial activity. (2) Methods: This study was conducted to prepare, assess and investigate the synergistic antibacterial activity of a chitosan-coated bacitracin cream. The results were compared to the antibacterial activity of simple bacitracin-loaded cream. The prepared cream was evaluated for various in vitro characteristics such as rheology, pH, viscosity, drug content and antibacterial activity studies. (3) Result: The formulations were found to be stable regarding color, liquefaction and phase separation at all accelerated conditions. It was observed that with time, substantial variations in the pH of the preparations were found. The introduction of chitosan results in controlled release of the drug from the formulations. The antibacterial activity of the formulated creams was assessed with the disc diffusion method against Staphylococcus aureus(ATCC),Escherichiacoli (STCC),Pseudomonas aeruginosa(ATCC) and Bacillus cereus(ATCC). The strains, E. coli, S. aureus, P. aeruginosa and B. cereus were susceptible to 50 µg chitosan-decorated bacitracin cream, showing inhibition zones of 10 ± 0.6, 34 ± 1.5, 31 ± 0.76 and 21 ± 2.02 mm, respectively. The zones of inhibition for simple bacitracin-loaded cream were significantly smaller than chitosan-decorated cream, at 2 ± 0.2, 28 ± 0.92, 15 ± 0.5 and 11 ± 1.25 mm (ANOVA; p < 0.05), respectively. (4) Conclusion: It was observed that the zones of inhibition of simple bacitracin-loaded cream were significantly smaller than those of chitosan-decorated bacitracin-loaded cream. Chitosan synergistically improves the antimicrobial activity of bacitracin. Hence, the developed formulation was effective and should be considered as a suitable candidate for topical management of skin infections and wound healing.

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Section: Resultsmentioning

confidence: 99%

Formulation, In Vitro Characterization and Antibacterial Activity of Chitosan-Decorated Cream Containing Bacitracin for Topical Delivery

et al. 2022

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Formulation cream from extract of red pidada leaves (Sonneratia caseolaris L.) as a sunscreen and analysis of active compounds with Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) method

Jubaidah

Syamsul

Supomo

et al. 2023

RJPT

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Exposure to intense and prolonged solar ultraviolet rays can cause erythema, premature aging, and skin cancer. The prevention of ultraviolet rays can be done by using sunscreen. Red Pidada leaves (Sonneratia caseolaris L.) have sunscreen properties. The purpose of this study was to preformulate red Pidada leaves into sunscreen cream preparations with the best activity as a cosmetic product prototype. This research will be started with the preparation of the red Pidada leaf ethanol extract formulated into a cream preparation with the extract concentration of Formula 1 (8%), Formula 2 (15%), and Formula 3 (20%). Evaluation of cream preparations includes organoleptic test, pH test, homogeneity test, dispersion test, adhesion test, viscosity test, and sunscreen effectiveness test. Data analysis used the One Way ANOVA test. The results of the physical quality test of cream showed that Formula 1 (8%) and Formula 2 (15%) met the requirements of the organoleptic test, homogeneity test, and adhesion test but did not meet the pH test, viscosity test, and spread ability test. Formula 3 (20%) fulfils the organoleptic test requirements and adhesion test requirements but does not meet the homogeneity test, pH test, viscosity test, and spread ability test. The sunscreen effectiveness test in formula 1 has the lowest Sun Protection Factor (SPF) value of 1.5 (without protection), formula 2 has an SPF value of 2.9 (minimum protection), and formula 3 has the highest SPF value of 7.4 (protection extra). Analysis of bioactive compounds in red Pidada ethanol extracts using LC-HRMS. There were 6 active compounds. Diisobutylphtalat, luteolin, apigethrin, vitexin, choline and bethain. Formula 3 performs better as a sunscreen than Formulas 1 and 2.

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Aromatherapy - An Overview

Kancharla,

Sundar,

Padmalatha

et al. 2023

AJPR

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Currently, volition and reciprocal curatives with the mainstream drug have gained instigation. Aromatherapy is a reciprocal remedy that uses essential canvases as the major remedial agents to treat several conditions. The essential or unpredictable canvases are uprooted from the flowers, dinghies, stems, leaves, roots, fruits, and other corridors of the factory in colourful styles. It came into actuality after scientists decrypted essential oil painting’s antiseptic and skin permeability parcels. Aromatherapy can do further than soothe your mind. Inhaling or absorbing sweet factory excerpts also may help soothe your body and relieve pain. Studies have shown that essential canvases have an effect on brainwaves and also alter geste. This review also aims to epitomize the randomized intervention. Studies have been carried out on using sweet factory excerpts (essential canvases) for various conditions. studies showed that the utmost essential canvases are decongestant, anti-microbial, anti-aging, and anti-spasmodic goods. Massage with essential oil painting improves blood rotation and increases endorphins, which naturally relieve the pain. This type of remedy utilizes colorful permutations and combinations to get relief from multitudinal affections like depression, indigestion, headache, wakefulness, muscular pain, respiratory problems, skin affections, blown joints, urine-associated complications, etc. The essential oils are found to be more effective when other aspects of life and diet aregiven due consideration.

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Formulation and Evaluation of Polyherbal Antiaging Cream

Cited by 6 publications

References 6 publications

Formulation, In Vitro Characterization and Antibacterial Activity of Chitosan-Decorated Cream Containing Bacitracin for Topical Delivery

Formulation, In Vitro Characterization and Antibacterial Activity of Chitosan-Decorated Cream Containing Bacitracin for Topical Delivery

Formulation cream from extract of red pidada leaves (Sonneratia caseolaris L.) as a sunscreen and analysis of active compounds with Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) method

Aromatherapy - An Overview

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