Formulation and Evaluation of Pharmaceuticaly Stable Serum of Duchesnea Indica (Arbenan)

Mursyid, A. Mumtihanah; Waris, Risda

doi:10.22270/ujpr.v6i1.538

Cited by 3 publications

(2 citation statements)

References 1 publication

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“…Particle size and size distribution A computerized inspection system was used to measure the particle size, size distribution, and zeta potential of an improved phytosomes formulation using dynamic light scattering (DLS) (Malvern Zetamaster ZEM 5002, Malvern, UK). By infusing the diluted system into a zeta potential measurement device, the electric potential of the phytosomes, including its Stern layer, was ascertained 17 .…”

Section: Entrapment Efficiencymentioning

confidence: 99%

Phytochemical Analysis and Estimation of Anti Oxidant Potential of Phytosomes Formulations of Morinda Lucida Benth

Al-Kaf

et al. 2023

Univ J Pharm Res

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Introduction: Lucid morinda (L) A medium-sized evergreen tree of the Morinda genus, the Benth (M. lucida, Rubiaceae) is a tropical West African rainforest plant that is also known as the Brimstone tree. In several West African nations, it is utilized in traditional medicine to cure a variety of human ailments. Phytosomes are freshly developed herbal formulations that have superior bioavailability and effects than traditional phyto molecules or botanical extracts because they are more readily absorbed. The goals of the current study were to evaluate ethanolic leaf extract of M. lucida's phytosomes, in vitro antioxidant properties, qualitative and quantitative phytochemical analyses, and phytosome formation. Methods: The ethanolic plant extract and cholesterol-containing phospholipids were used to make the phytosome. The entrapment efficiency, particle size and size distribution, optical microscopic research, stability tests, and in vitro dissolution investigations were used to characterize phytosomes. Alkaloids, glycosides, sterols, phenols, terpenoids, tannins, and saponins were found by phytochemical examination. Results: The ethanolic leaf extract of M. lucida contained 0.721 mg of total phenols and 0.464 mg of total alkaloids per 100 mg. Using industry-standard procedures, the ethanolic leaf extract's in vitro antioxidant activity was evaluated against the DPPH assay technique. Combining phospholipids and M. lucida can have a synergistic impact, which can be measured using the DPPH model for free radical scavenging activity. The optimised batch F10's particle size and entrapment efficiency were found to be 223.30±0.41 nm and 76.46±0.61 nm, respectively. Conclusion: It can be employed as a targeted medicine delivery system in the future for applications such as liver, brain, heart, etc. protection. The use of novel approaches rather than traditional methods for delivering herbal drugs increases the bioavailability of polar extracts and boosts patient compliance. Peer Review History: Received: 28 October 2022; Revised: 27 November; Accepted: 3 January 2023, Available online: 15 January 2023 Academic Editor: Dr. Gehan Fawzy Abdel Raoof Kandeel, Pharmacognosy Department, National Research Centre, Dokki, 12622, Giza, Egypt, gehankandeel9@yahoo.com Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, sansan4240732@163.com Dr. Hasniza Zaman Huri, University of Malaya Medical Centre, Kuala Lumpur, hasnizazh@ummc.edu.my Similar Articles: NUTRITIONAL COMPOSITION, CONSTITUENTS, AND ANTIOXIDANT ACTIVITY OF POWDER FRACTIONS OF FICUS DICRANOSTYLA MILDBREAD LEAVES IN VITRO ASSESSMENT OF ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES OF EXTRACTS OF YEMENI FAGONIA SCHWEINFURTHII HADIDI CYTOTOXIC EFFECT, ANTIOXIDANT POTENTIAL, AND PHYTOCHEMICAL STUDY OF THE ETHYL ACETATE EXTRACT OF PLEIOGYNIUM TIMORENSE SEEDS

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Section: Entrapment Efficiencymentioning

confidence: 99%

Phytochemical Analysis and Estimation of Anti Oxidant Potential of Phytosomes Formulations of Morinda Lucida Benth

Al-Kaf

et al. 2023

Univ J Pharm Res

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“…The cell was then placed inside the dissolution vessel of the dissolution tester machine. The vessel functioned as the receptor compartment and it was filled with phosphate buffer (pH7.4) which was the dissolution medium [13].…”

Section: In Vitro Drug Permeation Studiesmentioning

confidence: 99%

Formulation and evaluation of ivermectin emulgel formulations

Joshi,

Kumar,

Negi

et al. 2023

World Journal of Current Med and Pharm Research

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Ivermectin, a broad-spectrum antiparasitic agent, has demonstrated significant therapeutic efficacy against various skin conditions. However, it's poor skin permeability and limited stability often hinder its clinical application. Emulgel, a hybrid dosage form combining the advantages of both emulsions and gels, has emerged as a promising topical delivery system to enhance the skin permeation and stability of poorly permeable drugs. In this study, we aimed to formulate and characterize an Ivermectin emulgel to address the challenges associated with its topical delivery. The emulgel was prepared using a two-step method, involving the preparation of an oil-in-water (o/w) emulsion, which was then gelled with suitable gelling agents. Different concentrations of Ivermectin, oil phase, surfactants, and gelling agents were screened to optimize the formulation for maximum drug loading and stability. The optimized Ivermectin emulgel was characterized for its physicochemical properties, including pH, viscosity, spreadability, drug content, and rheological behavior. The study's findings support the potential application of the emulgel in treating various skin conditions caused by parasites and infectious agents. Further, in vivo studies and clinical trials are required to validate its safety and effectiveness in a clinical setting.

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Formulation of Gel Preparations of Ethanol Extract of Indian Strawberry (Duchesnea indica (Jacks.) Focke.)

Mursyid,

Waris,

W. Ilham

et al. 2023

RJPDFT

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The anti-inflammatory activity of Indian strawberry leaves is 0.31 percent DAI. For the treatment of inflammation, gel formulations are selected as effective penetration agents. The purpose of this work was to manufacture and test a pharmaceutically stable gel formulation of ethanol extract of Indian strawberry (Duchesnea indica (Jacks.) Focke] leaf with anti-inflammatory properties. This experimental study approach involved developing four formulas: F1 with 3% NaCMC, F2 with 4% NaCMC, F3 with 8% HPMC, and F4 with 9% HPMC. Then, the next test was evaluate the physical stability of the formulation using the following test parameters: organoleptic, pH, homogeneity, spreadability, and viscosity at 5°C and 35°C. The organoleptic test revealed that there was no difference between the four formulae in the color, odor, and consistency series. Each of the pH formulae that passed the pH test were suitable for topical application to the skin. For the homogeneity test all formulas are homogeneous. The best dispersion for the dispersion test was found in formulas 2, 3, and 4. Based on the rheogram, F1, F2, F3, and F4 had pseudoplastic flow characteristics. According to the results of the research conducted, the ethanol extract of Indian strawberry leaves can be formed into gel formulations based on HPMC and NaCMC. The gel formulation formula for ethanol extract of Indian strawberry leaves is pharmaceutically stable.

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Formulation and Evaluation of Pharmaceuticaly Stable Serum of Duchesnea Indica (Arbenan)

Cited by 3 publications

References 1 publication

Phytochemical Analysis and Estimation of Anti Oxidant Potential of Phytosomes Formulations of Morinda Lucida Benth

Phytochemical Analysis and Estimation of Anti Oxidant Potential of Phytosomes Formulations of Morinda Lucida Benth

Formulation and evaluation of ivermectin emulgel formulations

Formulation of Gel Preparations of Ethanol Extract of Indian Strawberry (Duchesnea indica (Jacks.) Focke.)

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