Formulation and Evaluation of Ondansetron Transdermal Gels

Rasheedy, Mai M.; El-Mahdy, M.; Fathallah, Dina; Ibrahim, El-Nobi A.

doi:10.21608/bfsa.2017.63166

Cited by 2 publications

(6 citation statements)

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“…Based on previous results obtained from ex vivo permeation studies, the suitable formulation that selected was ondansetron gel (F13: 7%w/w sodium alginate) [9]. In this study, the selected formula with different concentrations exhibited a slower, but higher extent of permeation in four hours than the I. V. application.…”

Section: Bioavailability Studies In Rabbitsmentioning

confidence: 91%

“…The remaining amount of distilled water required to prepare 100 g of the gel was added to the specified amounts of the gelling polymer sodium alginate (7% w/w) and soaked overnight for complete polymer solvation. The drug mixture was added slowly to the previously soaked polymer and continuously stirred to get the required gels using magnetic stirrer [9].…”

Section: Preparation Of Ondansetron Gel (F13)mentioning

confidence: 99%

“…Ondansetron sodium alginate gel (7%w/w) (F13) was selected for this study which showed a greater extent of permeation than other gels [9]. Marketed I. V. ondansetron (Zofran) ® A parallel design study was selected using nine healthy New Zealand rabbits weighing 1.75-2 kg (Animal house of faculty of Medicine, Assiut University-Egypt).…”

Section: Experimental Design a Bioavailability Studies In Rabbitsmentioning

confidence: 99%

“…Subsequently, it is very eligible to develop another delivery system to overcome the side effects associated with IV and/or oral dosage forms. So, ondansetron transdermal gel was formulated and evaluated from previous in vitro and ex vivo studies [9]. Whereas it is especially suitable for cancer patients who suffer from frequent episodes of vomiting and nausea and thus they cannot keep the oral dosage form and intravenous chemotherapy formerly worn out their veins.…”

Section: Introductionmentioning

confidence: 99%

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Bioavailability Study of Ondansetron Gel in Rabbits and Human Volunteers Appling Uplc as Analytical Tool and Evaluation of the Antiemetic Effect of Ondansetron Gel in Cisplatin-Induced Emesis in Rats

El-Mahdy

Rasheedy

Ibrahim

et al. 2020

Int J Pharm Pharm Sci

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Objective: This study was undertaken to determine the bioavailability of ondansetron gel in experimental animals and humans applying UPLC as an analytical tool and evaluation of the antiemetic effect of ondansetron gel in cisplatin-induced emesis in rats. Methods: Ondansetron gel (F13: sodium alginate 7% w/w) was used, marketed I. V. ondansetron (Zofran) ® was chosen as reference. The bioavailability study in rabbits was selected as a parallel design using nine healthy rabbits divided into three groups whereas, bioavailability study in humans was an open-label, wherein 6 healthy subjects administered ondansetron gel. The potential effect of ondansetron gel was evaluated for the prevention of different phases of emesis motivated by exposure to antineoplastic drugs (cisplatin) by determination of body weight loss, water and food intake applying kaolin-pica model in rats using seventy-two rats divided into six groups. Results: Ondansetron gel (0.5%) showed detectable plasma concentration 22.833±2.17 ng/m1 after ¼ h and 419.55±2.17 ng/ml after 1-h post-treatment in rabbits and human respectively and concentration was maintained above-reported minimum effective concentration for more than 2.5 h for rabbits and 7 h for humans compared to 1.75 h after I. V. administration. The ondansetron gel significantly reduces all phases of cisplatin-induced emesis and a decrease in body weight, water, and food consumption was significantly attenuated. Conclusion: Based on the high efficacy of gel on emesis induced by cisplatin, and its high bioavailability, transdermal ondansetron gel could be a promising convenient system to prevent nausea and vomiting following administration of antineoplastic drugs.

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Section: Bioavailability Studies In Rabbitsmentioning

confidence: 91%

Section: Preparation Of Ondansetron Gel (F13)mentioning

confidence: 99%

Section: Experimental Design a Bioavailability Studies In Rabbitsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bioavailability Study of Ondansetron Gel in Rabbits and Human Volunteers Appling Uplc as Analytical Tool and Evaluation of the Antiemetic Effect of Ondansetron Gel in Cisplatin-Induced Emesis in Rats

El-Mahdy

Rasheedy

Ibrahim

et al. 2020

Int J Pharm Pharm Sci

Self Cite

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“…Due to the basic character of the ONDS molecule that is related to the presence of indole and piperazine rings, it will be in the ionized form in the acidic medium (pH less than 7), ONDS solubility at acidic pH was significantly (p<0.05) higher than at alkaline pH (pH more than 7). As pH rises, the unionized species outnumber the ionized species, decreasing the apparent solubility at higher pH (27) . The volume of BPS used in the in vitro dissolution study was adequate to maintain sink condition as the volume used was 500±5 ml in a vessel of 900 ml capacity.…”

Section: Ondansetron Saturated Solubilitymentioning

confidence: 99%

Preparation, In-vitro, and Ex-vivo Evaluation of Ondansetron Loaded Invasomes for Transdermal Delivery

Salih,

Al-Akkam

2023

IJPS

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Invasomes are newly developed types of nanovesicles. A vesicular drug delivery system is considered one of the approaches for transdermal delivery to enhance permeation and improve drug bioavailability. Ondansetron is a serotonin receptor antagonist used for treating vomiting associated with different clinical cases. The study aimed to prepare invasomal dispersions for improving permeation of ondansetron across the skin with a controlled release pattern. Twenty-seven formulas of ondansetron-loaded invasomes were prepared by a modified mechanical dispersion method. These formulas were optimized by studying the effect of variables on entrapment efficiency. Vesicle size, polydispersity, zeta potential, in-vitro release and ex-vivo permeation studies were done for the optimized formulas. The selected formula was )F25( had )88.24%±0.04 (entrapment, (317.7 nm) vesicle size, (0.29) polydispersity, and (-31.5mV) zeta potential. In-vitro release study showed That (F25) had 75% release after (12) hrs., and dissolution followed the Korsmeyer-Peppas model with anomalous diffusion. Ex-vivo permeation study showed steady-state flux was 340.2 µg/cm2.hr with no lag time using rat skin tissue. A transmission electron microscope was done to visualize the selected formula. Invasomes are considered promising drug delivery systems for transdermal delivery of ondansetron, ensuring efficient permeation with a sustained release pattern.

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Formulation and Evaluation of Ondansetron Transdermal Gels

Cited by 2 publications

References 0 publications

Bioavailability Study of Ondansetron Gel in Rabbits and Human Volunteers Appling Uplc as Analytical Tool and Evaluation of the Antiemetic Effect of Ondansetron Gel in Cisplatin-Induced Emesis in Rats

Bioavailability Study of Ondansetron Gel in Rabbits and Human Volunteers Appling Uplc as Analytical Tool and Evaluation of the Antiemetic Effect of Ondansetron Gel in Cisplatin-Induced Emesis in Rats

Preparation, In-vitro, and Ex-vivo Evaluation of Ondansetron Loaded Invasomes for Transdermal Delivery

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